Moderators of respiratory muscle function in health, exercise and disease
type: CreativeWork
description: This research presents a series of studies investigating the role of the respiratory muscles in both healthy and diseased populations. To test directly the role of the respiratory muscles in a healthy population various strategies were used. Two studies examined the effects of training these muscles to bring about improvements in inspiratory strength and endurance and observe the effects of these changes on whole body performance. Following a 10-week intervention of inspiratory resistive loading (IRL) study one demonstrated a 34% increase in maximum inspiratory pressure and a 36% increase in cycling endurance capacity at 75% V̇O2peak (increased time by 1292 ± 607 seconds). During the trial heart rate (HR), ventilation (V̇E), and ratings of perceived exertion (RPE) were significantly reduced at the same time points. Study two examined the long-term effects (3 months) of non-invasive positive pressure ventilation (NIPPV) use in type II respiratory failure patients (PaO2 <7.3 kPa & PaCO2 >6.5 kPa). This treatment modality improved daytime blood gas tensions (PaO2 increased to 8.06 ± 1.24kPa; PaCO2 decreased to 6.45 ± 0.73 kPa), oxygen saturation (increased to 89.9 ± 3.7%), bicarbonate retention (decreased to 25.8 ± 3.86) and patient perception of health (as measured by St George’s Respiratory Questionnaire) in a group of patients receiving otherwise optimal treatment. In addition, both inspiratory muscle strength and endurance were improved relative to baseline following the three month intervention. Prevention of loss in body mass, particularly in the lean body compartment, is a potential method of alleviating muscle dysfunction in Chronic Obstructive Pulmonary Disease (COPD). Therapeutic doses of anabolic androgenic steroid (AAS) administration have been shown to increase maximal inspiratory pressure. Study three was designed to investigate the long-term effects of taking AAS (>20yrs) in a population of bodybuilders to help determine the safety aspect of the drugs wi…
abstract: This research presents a series of studies investigating the role of the respiratory muscles in both healthy and diseased populations. To test directly the role of the respiratory muscles in a healthy population various strategies were used. Two studies examined the effects of training these muscles to bring about improvements in inspiratory strength and endurance and observe the effects of these changes on whole body performance. Following a 10-week intervention of inspiratory resistive loading (IRL) study one demonstrated a 34% increase in maximum inspiratory pressure and a 36% increase in cycling endurance capacity at 75% V̇O2peak (increased time by 1292 ± 607 seconds). During the trial heart rate (HR), ventilation (V̇E), and ratings of perceived exertion (RPE) were significantly reduced at the same time points. Study two examined the long-term effects (3 months) of non-invasive positive pressure ventilation (NIPPV) use in type II respiratory failure patients (PaO2 <7.3 kPa & PaCO2 >6.5 kPa). This treatment modality improved daytime blood gas tensions (PaO2 increased to 8.06 ± 1.24kPa; PaCO2 decreased to 6.45 ± 0.73 kPa), oxygen saturation (increased to 89.9 ± 3.7%), bicarbonate retention (decreased to 25.8 ± 3.86) and patient perception of health (as measured by St George’s Respiratory Questionnaire) in a group of patients receiving otherwise optimal treatment. In addition, both inspiratory muscle strength and endurance were improved relative to baseline following the three month intervention. Prevention of loss in body mass, particularly in the lean body compartment, is a potential method of alleviating muscle dysfunction in Chronic Obstructive Pulmonary Disease (COPD). Therapeutic doses of anabolic androgenic steroid (AAS) administration have been shown to increase maximal inspiratory pressure. Study three was designed to investigate the long-term effects of taking AAS (>20yrs) in a population of bodybuilders to help determine the safety aspect of the drugs wi…
author: Gething, Alex
language: eng
date published: 2008
date modified: 2026-07-24T04:39:38Z
provider: University of South Wales
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of South Wales