The focus of this study is to investigate the vasculogenic potential of cells seeded on two different scaffolds, a commercially available collagen cell carrier (CCC) and the vitelline membrane (VM) from a chick egg. Two cell types with vasculogenic potential were used in this study, human umbilical vein endothelial cells (HUVECs) and rat bone marrow stem cells (BMSCs). The vaculogenesis as well as levels of SMαA and vWF expression were determined using confocal microscopy. This analysis of the two scaffolds showed that cells seeded onto the VM exhibited more rapid vasculogenesis than cells seeded on the CCC regardless of cell type. Future work will look into developing a scaffold using collagen and other biomolecules that mimics the structure of the VM to determine its role in promoting vasculogenesis.
","abstract_html":"<p>The focus of this study is to investigate the vasculogenic potential of cells seeded on two different scaffolds, a commercially available collagen cell carrier (CCC) and the vitelline membrane (VM) from a chick egg. Two cell types with vasculogenic potential were used in this study, human umbilical vein endothelial cells (HUVECs) and rat bone marrow stem cells (BMSCs). The vaculogenesis as well as levels of SMαA and vWF expression were determined using confocal microscopy. This analysis of the two scaffolds showed that cells seeded onto the VM exhibited more rapid vasculogenesis than cells seeded on the CCC regardless of cell type. Future work will look into developing a scaffold using collagen and other biomolecules that mimics the structure of the VM to determine its role in promoting vasculogenesis.</p>","abstract_has_math":false,"creators":["Stinson, Samantha Jo"],"institution":null,"degree_name":"M.S.","degree_level":"Campus Access Thesis","degree_discipline":"Biomedical Engineering","degree_department":null,"school":null,"contributors":["Richard L Goodwin"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2012,"date_issued":"2012-01-01T08:00:00Z","date_published":"2012-01-01T08:00:00Z","updated_at":"2026-07-24T04:38:23Z","subjects":["Biomedical","Electrical and Computer Engineering","Engineering","BMSC","HUVEC","Vascular Scaffold","Vasculogenesis","Vasculogenic Scaffold","Vitelline Membrane"],"languages":[],"rights":["© 2012, Samantha Jo Stinson"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://scholarcommons.sc.edu/etd/535","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Richard L Goodwin"]},{"key":"dc:creator","label":"Author","values":["Stinson, Samantha Jo"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Biomedical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Campus Access Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biomedical","Electrical and Computer Engineering","Engineering","BMSC","HUVEC","Vascular Scaffold","Vasculogenesis","Vasculogenic Scaffold","Vitelline Membrane"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["© 2012, Samantha Jo Stinson"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarcommons.sc.edu/etd/535"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The focus of this study is to investigate the vasculogenic potential of cells seeded on two different scaffolds, a commercially available collagen cell carrier (CCC) and the vitelline membrane (VM) from a chick egg. Two cell types with vasculogenic potential were used in this study, human umbilical vein endothelial cells (HUVECs) and rat bone marrow stem cells (BMSCs). The vaculogenesis as well as levels of SMαA and vWF expression were determined using confocal microscopy. This analysis of the two scaffolds showed that cells seeded onto the VM exhibited more rapid vasculogenesis than cells seeded on the CCC regardless of cell type. Future work will look into developing a scaffold using collagen and other biomolecules that mimics the structure of the VM to determine its role in promoting vasculogenesis.
"]},{"key":"dc:title","label":"Title","values":["Vasculogenic Scaffolds: How Cell-Cell and Cell-Matrix Interactions Regulate Vascular Differentiation and Morphogenesis"]}]}],"canonical_facts":{"dc:contributor":["Richard L Goodwin"],"dc:creator":["Stinson, Samantha Jo"],"dc:description.abstract":["The focus of this study is to investigate the vasculogenic potential of cells seeded on two different scaffolds, a commercially available collagen cell carrier (CCC) and the vitelline membrane (VM) from a chick egg. Two cell types with vasculogenic potential were used in this study, human umbilical vein endothelial cells (HUVECs) and rat bone marrow stem cells (BMSCs). The vaculogenesis as well as levels of SMαA and vWF expression were determined using confocal microscopy. This analysis of the two scaffolds showed that cells seeded onto the VM exhibited more rapid vasculogenesis than cells seeded on the CCC regardless of cell type. Future work will look into developing a scaffold using collagen and other biomolecules that mimics the structure of the VM to determine its role in promoting vasculogenesis.
"],"dc:identifier":["https://scholarcommons.sc.edu/etd/535"],"dc:rights":["© 2012, Samantha Jo Stinson"],"dc:subject":["Biomedical","Electrical and Computer Engineering","Engineering","BMSC","HUVEC","Vascular Scaffold","Vasculogenesis","Vasculogenic Scaffold","Vitelline Membrane"],"dc:title":["Vasculogenic Scaffolds: How Cell-Cell and Cell-Matrix Interactions Regulate Vascular Differentiation and Morphogenesis"],"thesis:degree_discipline":["Biomedical Engineering"],"thesis:degree_level":["Campus Access Thesis"],"thesis:degree_name":["M.S."]},"updated_at":"2026-07-24T04:38:23Z"}