{"id":{"repo_id":"soton","oai_identifier":"oai:eprints.soton.ac.uk:47762"},"canonical_url":"https://search.dev.ndltd.org/etd/soton/oai:eprints.soton.ac.uk:47762","repository":{"repo_id":"soton","name":"University of Southampton","base_url":"https://eprints.soton.ac.uk/cgi/oai2"},"display":{"title":"Optical diffraction-based silicon sensors for the detection of DNA sequences","abstract":"This thesis describes the design, fabrication and characterisation of diffraction-based sensors on silicon (100) substrates for the detection of complementary DNA sequences using colloidal gold labels. In-depth analysis of variations of DNA sequence within the human genome and association with diseases is expected to lead to personalised medical treatment. There is a great need for DNA analysis technologies and for techniques to determine whether sequence variations occur on the same chromosomal strand with applications in disease screening and diagnosis. Novel two-dimensional diffraction structures are designed and fabricated. It is shown that two-dimensional diffraction approaches may potentially offer multiplexing of DNA detection assays.","abstract_html":"This thesis describes the design, fabrication and characterisation of diffraction-based sensors on silicon (100) substrates for the detection of complementary DNA sequences using colloidal gold labels. In-depth analysis of variations of DNA sequence within the human genome and association with diseases is expected to lead to personalised medical treatment. There is a great need for DNA analysis technologies and for techniques to determine whether sequence variations occur on the same chromosomal strand with applications in disease screening and diagnosis. Novel two-dimensional diffraction structures are designed and fabricated. It is shown that two-dimensional diffraction approaches may potentially offer multiplexing of DNA detection assays.","abstract_has_math":false,"creators":["Weld, Andrew Mark"],"institution":"University of Southampton","degree_name":"Ph.D.","degree_level":"doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2007,"date_issued":"2007-06","date_published":"2007-06","updated_at":"2026-07-24T04:35:50Z","subjects":[],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Weld, Andrew Mark"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2007-06-29"]},{"key":"dc:date.issued","label":"Date","values":["2007-06"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Optoelectronics Research Centre (pre 2011 reorg)","Optoelectronic Research Centre"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Southampton"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://eprints.soton.ac.uk/47762/"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["Ph.D."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://eprints.soton.ac.uk/47762/1/Weld_2007_thesis_3858.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["This thesis describes the design, fabrication and characterisation of diffraction-based sensors on silicon (100) substrates for the detection of complementary DNA sequences using colloidal gold labels. In-depth analysis of variations of DNA sequence within the human genome and association with diseases is expected to lead to personalised medical treatment. There is a great need for DNA analysis technologies and for techniques to determine whether sequence variations occur on the same chromosomal strand with applications in disease screening and diagnosis. Novel two-dimensional diffraction structures are designed and fabricated. It is shown that two-dimensional diffraction approaches may potentially offer multiplexing of DNA detection assays."]},{"key":"dc:format","label":"Dc Format","values":["text"]},{"key":"dc:title","label":"Title","values":["Optical diffraction-based silicon sensors for the detection of DNA sequences"]}]}],"canonical_facts":{"dc:creator":["Weld, Andrew Mark"],"dc:date":["2007-06-29"],"dc:date.issued":["2007-06"],"dc:description.abstract":["This thesis describes the design, fabrication and characterisation of diffraction-based sensors on silicon (100) substrates for the detection of complementary DNA sequences using colloidal gold labels. In-depth analysis of variations of DNA sequence within the human genome and association with diseases is expected to lead to personalised medical treatment. There is a great need for DNA analysis technologies and for techniques to determine whether sequence variations occur on the same chromosomal strand with applications in disease screening and diagnosis. Novel two-dimensional diffraction structures are designed and fabricated. It is shown that two-dimensional diffraction approaches may potentially offer multiplexing of DNA detection assays."],"dc:format":["text"],"dc:identifier.uri":["https://eprints.soton.ac.uk/47762/1/Weld_2007_thesis_3858.pdf"],"dc:publisher.department":["Optoelectronics Research Centre (pre 2011 reorg)","Optoelectronic Research Centre"],"dc:publisher.institution":["University of Southampton"],"dc:relation.isreferencedby":["https://eprints.soton.ac.uk/47762/"],"dc:title":["Optical diffraction-based silicon sensors for the detection of DNA sequences"],"dc:type":["Thesis"],"dc:type.qualificationlevel":["doctoral"],"dc:type.qualificationname":["Ph.D."]},"updated_at":"2026-07-24T04:35:50Z"}