{"id":{"repo_id":"soton","oai_identifier":"oai:eprints.soton.ac.uk:167749"},"canonical_url":"https://search.dev.ndltd.org/etd/soton/oai:eprints.soton.ac.uk:167749","repository":{"repo_id":"soton","name":"University of Southampton","base_url":"https://eprints.soton.ac.uk/cgi/oai2"},"display":{"title":"The development of a simple process for producing medicinal diagnostic 18F agents for molecular imaging using positron-emission-tomography","abstract":"A range of resin bound sulfonate ester linkers were developed for use in the resin-linker-vector (RLV) approach for the synthesis of [18F]-fluoride radiotracers for use as imaging agents in positron-emission-tomography (PET). The RLV strategy immobilises a precursor to the desired radiotracer on a solid support which is cleaved on exposure to [18F]-fluoride ion to give the 18F-labelled radiotracer in solution. The RLV methodology allows for easier purification of the 18F-labelled radiotracer as a simple filtration step removes the unreacted starting material and the cleaved resin.<br/><br/>Synthetic routes to a 4-allkylphenylsulfonate linker and a 4-nitrophenylsulfonate linker were developed and these were shown to work as desired as part of the RLV construct in [19F]-fluoridolysis reactions. [18F]-Fluoridolysis reactions using the 4-alkylphenylsulfonate linker gave the desired 18F-labelled product in excellent radiochemical purity. The RLV strategy with this linker type was applied in a new synthetic route to O-(2-[18F]-fluoroethyl)-L-tyrosine.<br/><br/>A fluorinated analogue of Alzheimer’s disease drug (?)-galanthamine was synthesised with complete stereocontrol as a potential new imaging agent for use in PET.","abstract_html":"A range of resin bound sulfonate ester linkers were developed for use in the resin-linker-vector (RLV) approach for the synthesis of [18F]-fluoride radiotracers for use as imaging agents in positron-emission-tomography (PET). The RLV strategy immobilises a precursor to the desired radiotracer on a solid support which is cleaved on exposure to [18F]-fluoride ion to give the 18F-labelled radiotracer in solution. The RLV methodology allows for easier purification of the 18F-labelled radiotracer as a simple filtration step removes the unreacted starting material and the cleaved resin.&lt;br/&gt;&lt;br/&gt;Synthetic routes to a 4-allkylphenylsulfonate linker and a 4-nitrophenylsulfonate linker were developed and these were shown to work as desired as part of the RLV construct in [19F]-fluoridolysis reactions. [18F]-Fluoridolysis reactions using the 4-alkylphenylsulfonate linker gave the desired 18F-labelled product in excellent radiochemical purity. The RLV strategy with this linker type was applied in a new synthetic route to O-(2-[18F]-fluoroethyl)-L-tyrosine.&lt;br/&gt;&lt;br/&gt;A fluorinated analogue of Alzheimer’s disease drug (?)-galanthamine was synthesised with complete stereocontrol as a potential new imaging agent for use in PET.","abstract_has_math":false,"creators":["Topley, Amy Clare"],"institution":"University of Southampton","degree_name":"Ph.D.","degree_level":"doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Brown, Richard C.D."],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010-06","date_published":"2010-06","updated_at":"2026-07-24T04:36:17Z","subjects":[],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Brown, Richard C.D."]},{"key":"dc:creator","label":"Author","values":["Topley, Amy Clare"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2010-06"]},{"key":"dc:date.issued","label":"Date","values":["2010-06"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Chemistry (pre 2011 reorg)","School of Chemistry"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Southampton"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://eprints.soton.ac.uk/167749/"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["Ph.D."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://eprints.soton.ac.uk/167749/1/Thesis_Amy_Topley.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["A range of resin bound sulfonate ester linkers were developed for use in the resin-linker-vector (RLV) approach for the synthesis of [18F]-fluoride radiotracers for use as imaging agents in positron-emission-tomography (PET). The RLV strategy immobilises a precursor to the desired radiotracer on a solid support which is cleaved on exposure to [18F]-fluoride ion to give the 18F-labelled radiotracer in solution. The RLV methodology allows for easier purification of the 18F-labelled radiotracer as a simple filtration step removes the unreacted starting material and the cleaved resin.<br/><br/>Synthetic routes to a 4-allkylphenylsulfonate linker and a 4-nitrophenylsulfonate linker were developed and these were shown to work as desired as part of the RLV construct in [19F]-fluoridolysis reactions. [18F]-Fluoridolysis reactions using the 4-alkylphenylsulfonate linker gave the desired 18F-labelled product in excellent radiochemical purity. The RLV strategy with this linker type was applied in a new synthetic route to O-(2-[18F]-fluoroethyl)-L-tyrosine.<br/><br/>A fluorinated analogue of Alzheimer’s disease drug (?)-galanthamine was synthesised with complete stereocontrol as a potential new imaging agent for use in PET."]},{"key":"dc:format","label":"Dc Format","values":["text"]},{"key":"dc:title","label":"Title","values":["The development of a simple process for producing medicinal diagnostic 18F agents for molecular imaging using positron-emission-tomography"]}]}],"canonical_facts":{"dc:contributor.advisor":["Brown, Richard C.D."],"dc:creator":["Topley, Amy Clare"],"dc:date":["2010-06"],"dc:date.issued":["2010-06"],"dc:description.abstract":["A range of resin bound sulfonate ester linkers were developed for use in the resin-linker-vector (RLV) approach for the synthesis of [18F]-fluoride radiotracers for use as imaging agents in positron-emission-tomography (PET). The RLV strategy immobilises a precursor to the desired radiotracer on a solid support which is cleaved on exposure to [18F]-fluoride ion to give the 18F-labelled radiotracer in solution. The RLV methodology allows for easier purification of the 18F-labelled radiotracer as a simple filtration step removes the unreacted starting material and the cleaved resin.<br/><br/>Synthetic routes to a 4-allkylphenylsulfonate linker and a 4-nitrophenylsulfonate linker were developed and these were shown to work as desired as part of the RLV construct in [19F]-fluoridolysis reactions. [18F]-Fluoridolysis reactions using the 4-alkylphenylsulfonate linker gave the desired 18F-labelled product in excellent radiochemical purity. The RLV strategy with this linker type was applied in a new synthetic route to O-(2-[18F]-fluoroethyl)-L-tyrosine.<br/><br/>A fluorinated analogue of Alzheimer’s disease drug (?)-galanthamine was synthesised with complete stereocontrol as a potential new imaging agent for use in PET."],"dc:format":["text"],"dc:identifier.uri":["https://eprints.soton.ac.uk/167749/1/Thesis_Amy_Topley.pdf"],"dc:publisher.department":["Chemistry (pre 2011 reorg)","School of Chemistry"],"dc:publisher.institution":["University of Southampton"],"dc:relation.isreferencedby":["https://eprints.soton.ac.uk/167749/"],"dc:title":["The development of a simple process for producing medicinal diagnostic 18F agents for molecular imaging using positron-emission-tomography"],"dc:type":["Thesis"],"dc:type.qualificationlevel":["doctoral"],"dc:type.qualificationname":["Ph.D."]},"updated_at":"2026-07-24T04:36:17Z"}