{"id":{"repo_id":"sherbrooke","oai_identifier":"oai:usherbrooke.scholaris.ca:11143/19503"},"canonical_url":"https://search.dev.ndltd.org/etd/sherbrooke/oai:usherbrooke.scholaris.ca:11143/19503","repository":{"repo_id":"sherbrooke","name":"Université de Sherbrooke","base_url":"https://usherbrooke.scholaris.ca/server/oai/request"},"display":{"title":"Étude des liens entre les mesures quantitatives de la vascularisation cérébrale, les fonctions cognitives et la neuropathologie dans la maladie d’Alzheimer","abstract":"Introduction: With the aging of the world population, it is estimated that approximately 78 million people worldwide will be affected by a major neurocognitive disorder (TNC) in 2030. However, the etiology of Alzheimer's disease (AD), the most common form of major TNC, remains unclear. Given the growing body of evidence supporting a relationship between vascular factors and AD, the present project explored the cerebrovascular component as a potential pathophysiological mechanism of this disease. Objectives: Explore the relationship between 1) the diameters of the posterior cerebral arteries, 2nd segment (ACP2) and of the anterior choroidal arteries (AchA) and the Clinical Dementia Rating Scale – Sum of Boxes (CDR-SB) and 2) the diameters and the volumes of cerebral arteries and i) cognition; ii) AD neuropathology, such as hippocampal atrophy, cerebral atrophy, and amyloid burden; iii) cognitive decline. Methodology: Participants were selected from the OASIS-3 database. Intracranial arteries were assessed by time-of-flight magnetic resonance angiography (TOF-MRA) and their quantitative measurements were calculated using a newly developed artificial intelligence algorithm. Cognitive status was assessed by MMSE (Mini-Mental State Examination), CDR, and several neuropsychological tests, including Logical Memory and Trail Making tests. Amyloid burden was visualized by amyloid PET with contrast and quantified using the Centiloid scale. Brain and hippocampal volumes were assessed by T1-weighted MRI. Results: The primary results showed that ACP2 and AchA diameters were not significantly correlated with CDR-SB scores. For secondary outcomes, AchA had the most associations (nonlinear and negative) with cognitive functions and AD markers. Conversely, the anterior cerebral arteries (ACA), the basilar artery, and the posterior cerebral arteries, 1st segment (ACP1) had very little relationship with cognition. Among the statistically significant secondary results, the correlations were of low intensity. Conclusion: Using TOF-MRA imaging and artificial intelligence technology, we were able to calculate the quantitative measurements of the intracranial arteries and thus assess their association with certain AD elements. Future research should be conducted to overcome the limitations of the present study in order to confirm these findings.","abstract_html":"Introduction: With the aging of the world population, it is estimated that approximately 78 million people worldwide will be affected by a major neurocognitive disorder (TNC) in 2030. However, the etiology of Alzheimer's disease (AD), the most common form of major TNC, remains unclear. Given the growing body of evidence supporting a relationship between vascular factors and AD, the present project explored the cerebrovascular component as a potential pathophysiological mechanism of this disease. Objectives: Explore the relationship between 1) the diameters of the posterior cerebral arteries, 2nd segment (ACP2) and of the anterior choroidal arteries (AchA) and the Clinical Dementia Rating Scale – Sum of Boxes (CDR-SB) and 2) the diameters and the volumes of cerebral arteries and i) cognition; ii) AD neuropathology, such as hippocampal atrophy, cerebral atrophy, and amyloid burden; iii) cognitive decline. Methodology: Participants were selected from the OASIS-3 database. Intracranial arteries were assessed by time-of-flight magnetic resonance angiography (TOF-MRA) and their quantitative measurements were calculated using a newly developed artificial intelligence algorithm. Cognitive status was assessed by MMSE (Mini-Mental State Examination), CDR, and several neuropsychological tests, including Logical Memory and Trail Making tests. Amyloid burden was visualized by amyloid PET with contrast and quantified using the Centiloid scale. Brain and hippocampal volumes were assessed by T1-weighted MRI. Results: The primary results showed that ACP2 and AchA diameters were not significantly correlated with CDR-SB scores. For secondary outcomes, AchA had the most associations (nonlinear and negative) with cognitive functions and AD markers. Conversely, the anterior cerebral arteries (ACA), the basilar artery, and the posterior cerebral arteries, 1st segment (ACP1) had very little relationship with cognition. Among the statistically significant secondary results, the correlations were of low intensity. Conclusion: Using TOF-MRA imaging and artificial intelligence technology, we were able to calculate the quantitative measurements of the intracranial arteries and thus assess their association with certain AD elements. Future research should be conducted to overcome the limitations of the present study in order to confirm these findings.","abstract_has_math":false,"creators":["Ni, Vivian"],"institution":"Université de Sherbrooke","degree_name":"M. Sc.","degree_level":"Maîtrise","degree_discipline":"Gérontologie","degree_department":null,"school":null,"contributors":[],"advisors":["Bocti, Christian","Whittingstall, Kevin"],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022","date_published":"2022","updated_at":"2026-07-27T21:07:43Z","subjects":["Maladie d’Alzheimer","TOF-MRA","Cercle de Willis","Artères choroïdiennes antérieures","Fonctions cognitives","Fardeau amyloïde","Hippocampe","Volume cérébral","Alzheimer’s disease","Circle of Willis","Anterior choroidal arteries","Cognitive functions","Amyloid burden","Hippocampus","Cerebral volume"],"languages":["fr"],"rights":[],"rights_urls":["http://creativecommons.org/licenses/by-nc-nd/2.5/ca/"],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11143/19503","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Bocti, Christian","Whittingstall, Kevin"]},{"key":"dc:creator","label":"Author","values":["Ni, Vivian"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2022-08-16T19:00:52Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2022-08-16T19:00:52Z"]},{"key":"dc:date.issued","label":"Date","values":["2022"]},{"key":"dc:publisher","label":"Institution","values":["Université de Sherbrooke"]},{"key":"dc:type","label":"Dc Type","values":["Mémoire de maîtrise"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Gérontologie"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Maîtrise"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M. Sc."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Faculté de médecine et des sciences de la santé"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Maladie d’Alzheimer","TOF-MRA","Cercle de Willis","Artères choroïdiennes antérieures","Fonctions cognitives","Fardeau amyloïde","Hippocampe","Volume cérébral","Alzheimer’s disease","Circle of Willis","Anterior choroidal arteries","Cognitive functions","Amyloid burden","Hippocampus","Cerebral volume"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["fr"]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://creativecommons.org/licenses/by-nc-nd/2.5/ca/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11143/19503"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Introduction: With the aging of the world population, it is estimated that approximately 78 million people worldwide will be affected by a major neurocognitive disorder (TNC) in 2030. However, the etiology of Alzheimer's disease (AD), the most common form of major TNC, remains unclear. Given the growing body of evidence supporting a relationship between vascular factors and AD, the present project explored the cerebrovascular component as a potential pathophysiological mechanism of this disease. Objectives: Explore the relationship between 1) the diameters of the posterior cerebral arteries, 2nd segment (ACP2) and of the anterior choroidal arteries (AchA) and the Clinical Dementia Rating Scale – Sum of Boxes (CDR-SB) and 2) the diameters and the volumes of cerebral arteries and i) cognition; ii) AD neuropathology, such as hippocampal atrophy, cerebral atrophy, and amyloid burden; iii) cognitive decline. Methodology: Participants were selected from the OASIS-3 database. Intracranial arteries were assessed by time-of-flight magnetic resonance angiography (TOF-MRA) and their quantitative measurements were calculated using a newly developed artificial intelligence algorithm. Cognitive status was assessed by MMSE (Mini-Mental State Examination), CDR, and several neuropsychological tests, including Logical Memory and Trail Making tests. Amyloid burden was visualized by amyloid PET with contrast and quantified using the Centiloid scale. Brain and hippocampal volumes were assessed by T1-weighted MRI. Results: The primary results showed that ACP2 and AchA diameters were not significantly correlated with CDR-SB scores. For secondary outcomes, AchA had the most associations (nonlinear and negative) with cognitive functions and AD markers. Conversely, the anterior cerebral arteries (ACA), the basilar artery, and the posterior cerebral arteries, 1st segment (ACP1) had very little relationship with cognition. Among the statistically significant secondary results, the correlations were of low intensity. Conclusion: Using TOF-MRA imaging and artificial intelligence technology, we were able to calculate the quantitative measurements of the intracranial arteries and thus assess their association with certain AD elements. Future research should be conducted to overcome the limitations of the present study in order to confirm these findings.","Introduction : Avec le vieillissement de la population mondiale, il est estimé qu’environ 78 millions de personnes seront atteintes d’un trouble neurocognitif (TNC) majeur en 2030. Pourtant, l’étiologie de la maladie d’Alzheimer (MA), la forme la plus commune de TNC majeur, demeure incertaine. Étant donné le nombre croissant de preuves soutenant une relation entre les facteurs vasculaires et la MA, le présent projet a exploré la composante cérébrovasculaire en tant que mécanisme pathophysiologique potentiel de cette maladie. Objectifs : Explorer la relation entre 1) les diamètres des artères cérébrales postérieures, 2e segment (ACP2) et des artères choroïdiennes antérieures (AchA) et le Clinical Dementia Rating Scale – Sum of Boxes (CDR-SB) et 2) les diamètres et les volumes des artères cérébrales et i) la cognition; ii) la neuropathologie de la MA, soit l’atrophie de l’hippocampe, l’atrophie cérébrale et le fardeau amyloïde; iii) le suivi cognitif. Méthodologie : Les sujets ont été sélectionnés de la base de données OASIS-3. Les artères intracrâniennes ont été évaluées par angiographie par résonance magnétique par temps de vol (TOF-MRA) et leurs mesures quantitatives ont été calculées à l’aide d’un algorithme d’intelligence artificielle nouvellement développé. Le statut cognitif a été évalué par MMSE (Mini-Mental State Examination), CDR et plusieurs tests neuropsychologiques, dont les tests Logical Memory et Trail Making. Le fardeau amyloïde a été visualisé par TEP amyloïde avec produit de contraste et quantifié à l’aide de l’échelle Centiloïde. Les volumes du cerveau et de l’hippocampe ont été évalués par IRM pondérée en T1. Résultats : Les résultats primaires montraient que les diamètres des ACP2 et des AchA n’étaient pas significativement corrélés avec les scores CDR-SB. Pour les résultats secondaires, les AchA avaient le plus d’associations (non linéaires et négatives) avec la cognition et les marqueurs de la MA. À l’inverse, les artères cérébrales antérieures (ACA), l’artère basilaire et les artères cérébrale postérieures, 1e segment (ACP1) avaient très peu de relations avec la cognition. Parmi les résultats secondaires statistiquement significatifs, les corrélations étaient de faible intensité. Conclusion : À l’aide de l’imagerie TOF-MRA et de la technologie d’intelligence artificielle, nous avons pu calculer les mesures quantitatives des artères intracrâniennes et ainsi évaluer leur association avec certains éléments de la MA. Des recherches futures doivent être menées pour surmonter les limites de la présente étude afin de confirmer ces découvertes."]},{"key":"dc:title","label":"Title","values":["Étude des liens entre les mesures quantitatives de la vascularisation cérébrale, les fonctions cognitives et la neuropathologie dans la maladie d’Alzheimer"]}]}],"canonical_facts":{"dc:contributor.advisor":["Bocti, Christian","Whittingstall, Kevin"],"dc:creator":["Ni, Vivian"],"dc:date.accessioned":["2022-08-16T19:00:52Z"],"dc:date.available":["2022-08-16T19:00:52Z"],"dc:date.issued":["2022"],"dc:description.abstract":["Introduction: With the aging of the world population, it is estimated that approximately 78 million people worldwide will be affected by a major neurocognitive disorder (TNC) in 2030. However, the etiology of Alzheimer's disease (AD), the most common form of major TNC, remains unclear. Given the growing body of evidence supporting a relationship between vascular factors and AD, the present project explored the cerebrovascular component as a potential pathophysiological mechanism of this disease. Objectives: Explore the relationship between 1) the diameters of the posterior cerebral arteries, 2nd segment (ACP2) and of the anterior choroidal arteries (AchA) and the Clinical Dementia Rating Scale – Sum of Boxes (CDR-SB) and 2) the diameters and the volumes of cerebral arteries and i) cognition; ii) AD neuropathology, such as hippocampal atrophy, cerebral atrophy, and amyloid burden; iii) cognitive decline. Methodology: Participants were selected from the OASIS-3 database. Intracranial arteries were assessed by time-of-flight magnetic resonance angiography (TOF-MRA) and their quantitative measurements were calculated using a newly developed artificial intelligence algorithm. Cognitive status was assessed by MMSE (Mini-Mental State Examination), CDR, and several neuropsychological tests, including Logical Memory and Trail Making tests. Amyloid burden was visualized by amyloid PET with contrast and quantified using the Centiloid scale. Brain and hippocampal volumes were assessed by T1-weighted MRI. Results: The primary results showed that ACP2 and AchA diameters were not significantly correlated with CDR-SB scores. For secondary outcomes, AchA had the most associations (nonlinear and negative) with cognitive functions and AD markers. Conversely, the anterior cerebral arteries (ACA), the basilar artery, and the posterior cerebral arteries, 1st segment (ACP1) had very little relationship with cognition. Among the statistically significant secondary results, the correlations were of low intensity. Conclusion: Using TOF-MRA imaging and artificial intelligence technology, we were able to calculate the quantitative measurements of the intracranial arteries and thus assess their association with certain AD elements. Future research should be conducted to overcome the limitations of the present study in order to confirm these findings.","Introduction : Avec le vieillissement de la population mondiale, il est estimé qu’environ 78 millions de personnes seront atteintes d’un trouble neurocognitif (TNC) majeur en 2030. Pourtant, l’étiologie de la maladie d’Alzheimer (MA), la forme la plus commune de TNC majeur, demeure incertaine. Étant donné le nombre croissant de preuves soutenant une relation entre les facteurs vasculaires et la MA, le présent projet a exploré la composante cérébrovasculaire en tant que mécanisme pathophysiologique potentiel de cette maladie. Objectifs : Explorer la relation entre 1) les diamètres des artères cérébrales postérieures, 2e segment (ACP2) et des artères choroïdiennes antérieures (AchA) et le Clinical Dementia Rating Scale – Sum of Boxes (CDR-SB) et 2) les diamètres et les volumes des artères cérébrales et i) la cognition; ii) la neuropathologie de la MA, soit l’atrophie de l’hippocampe, l’atrophie cérébrale et le fardeau amyloïde; iii) le suivi cognitif. Méthodologie : Les sujets ont été sélectionnés de la base de données OASIS-3. Les artères intracrâniennes ont été évaluées par angiographie par résonance magnétique par temps de vol (TOF-MRA) et leurs mesures quantitatives ont été calculées à l’aide d’un algorithme d’intelligence artificielle nouvellement développé. Le statut cognitif a été évalué par MMSE (Mini-Mental State Examination), CDR et plusieurs tests neuropsychologiques, dont les tests Logical Memory et Trail Making. Le fardeau amyloïde a été visualisé par TEP amyloïde avec produit de contraste et quantifié à l’aide de l’échelle Centiloïde. Les volumes du cerveau et de l’hippocampe ont été évalués par IRM pondérée en T1. Résultats : Les résultats primaires montraient que les diamètres des ACP2 et des AchA n’étaient pas significativement corrélés avec les scores CDR-SB. Pour les résultats secondaires, les AchA avaient le plus d’associations (non linéaires et négatives) avec la cognition et les marqueurs de la MA. À l’inverse, les artères cérébrales antérieures (ACA), l’artère basilaire et les artères cérébrale postérieures, 1e segment (ACP1) avaient très peu de relations avec la cognition. Parmi les résultats secondaires statistiquement significatifs, les corrélations étaient de faible intensité. Conclusion : À l’aide de l’imagerie TOF-MRA et de la technologie d’intelligence artificielle, nous avons pu calculer les mesures quantitatives des artères intracrâniennes et ainsi évaluer leur association avec certains éléments de la MA. Des recherches futures doivent être menées pour surmonter les limites de la présente étude afin de confirmer ces découvertes."],"dc:identifier.uri":["http://hdl.handle.net/11143/19503"],"dc:language.iso":["fr"],"dc:publisher":["Université de Sherbrooke"],"dc:rights.uri":["http://creativecommons.org/licenses/by-nc-nd/2.5/ca/"],"dc:subject":["Maladie d’Alzheimer","TOF-MRA","Cercle de Willis","Artères choroïdiennes antérieures","Fonctions cognitives","Fardeau amyloïde","Hippocampe","Volume cérébral","Alzheimer’s disease","Circle of Willis","Anterior choroidal arteries","Cognitive functions","Amyloid burden","Hippocampus","Cerebral volume"],"dc:title":["Étude des liens entre les mesures quantitatives de la vascularisation cérébrale, les fonctions cognitives et la neuropathologie dans la maladie d’Alzheimer"],"dc:type":["Mémoire de maîtrise"],"thesis:degree_discipline":["Gérontologie"],"thesis:degree_level":["Maîtrise"],"thesis:degree_name":["M. Sc."],"thesis:institution_name":["Faculté de médecine et des sciences de la santé"]},"updated_at":"2026-07-27T21:07:43Z"}