{"id":{"repo_id":"sherbrooke","oai_identifier":"oai:usherbrooke.scholaris.ca:11143/19246"},"canonical_url":"https://search.dev.ndltd.org/etd/sherbrooke/oai:usherbrooke.scholaris.ca:11143/19246","repository":{"repo_id":"sherbrooke","name":"Université de Sherbrooke","base_url":"https://usherbrooke.scholaris.ca/server/oai/request"},"display":{"title":"Effet des statines sur les maladies cardiovasculaires chez les personnes âgées de 75 ans et plus","abstract":"Introduction: As the population ages the rate of cardiovascular events is continually increasing. Compared to younger, people aged 75 and over are three times more susceptible to cardiovascular complications. According to Canadian guidelines statins are recommended for the prevention of cardiovascular diseases. However, the effects of statins in preventing cardiovascular events in people aged 75 and over remain unclear. In addition, this population is often absent or underrepresented in most studies. Objective: Our research aim was to study the association between the use of statins and the occurrence of angina, myocardial infarction and stroke in people aged 75 years and older. Methods: In this retrospective cohort study, we used the database of the CIRESSS (Computerized Center for Evaluative Research in Health Services and Care) at the University Hospital of Sherbrooke (Quebec, Canada) (CHUS). 4089 men and women aged 75 and over, admitted to the Sherbrooke University Hospital and recorded in the electronic medical records (Ariane) between 2007 and 2017, were classified into two groups: those who used the statin (GS) and those who did not (GNS). The effect of statin use on the occurrence of myocardial infarction, angina or stroke was analyzed using logistic regression. Results: 143 angina incidents were recorded in the GS group compared to 53 events in the GNS group (OR 3.37 ; 2.26-5.07 ; p <0.001). There were 435 myocardial infarction occurrences in the GS group compared to 157 in the GNS group (OR 4.43 ; 3.44-5.71 ; p <0.001). Regarding stroke, it was higher in the GS group at 9.32% compared to 5.93% in the GNS group with no signification (OR 0.74 ; 0.53-1.02 ; p=0.0676). Conclusion: The use of statins was significantly associated with the increased risk for coronary heart disease. However, no significant effect was observed on the stroke.","abstract_html":"Introduction: As the population ages the rate of cardiovascular events is continually increasing. Compared to younger, people aged 75 and over are three times more susceptible to cardiovascular complications. According to Canadian guidelines statins are recommended for the prevention of cardiovascular diseases. However, the effects of statins in preventing cardiovascular events in people aged 75 and over remain unclear. In addition, this population is often absent or underrepresented in most studies. Objective: Our research aim was to study the association between the use of statins and the occurrence of angina, myocardial infarction and stroke in people aged 75 years and older. Methods: In this retrospective cohort study, we used the database of the CIRESSS (Computerized Center for Evaluative Research in Health Services and Care) at the University Hospital of Sherbrooke (Quebec, Canada) (CHUS). 4089 men and women aged 75 and over, admitted to the Sherbrooke University Hospital and recorded in the electronic medical records (Ariane) between 2007 and 2017, were classified into two groups: those who used the statin (GS) and those who did not (GNS). The effect of statin use on the occurrence of myocardial infarction, angina or stroke was analyzed using logistic regression. Results: 143 angina incidents were recorded in the GS group compared to 53 events in the GNS group (OR 3.37 ; 2.26-5.07 ; p &lt;0.001). There were 435 myocardial infarction occurrences in the GS group compared to 157 in the GNS group (OR 4.43 ; 3.44-5.71 ; p &lt;0.001). Regarding stroke, it was higher in the GS group at 9.32% compared to 5.93% in the GNS group with no signification (OR 0.74 ; 0.53-1.02 ; p=0.0676). Conclusion: The use of statins was significantly associated with the increased risk for coronary heart disease. However, no significant effect was observed on the stroke.","abstract_has_math":false,"creators":["Mathlouthi, Mohamed"],"institution":"Université de Sherbrooke","degree_name":"M. Sc.","degree_level":"Maîtrise","degree_discipline":"Sciences cliniques","degree_department":null,"school":null,"contributors":[],"advisors":["Khalil, Abdelouahed","Fülöp, Tamas"],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022","date_published":"2022","updated_at":"2026-07-27T21:07:34Z","subjects":["Maladies cardiovasculaires","Statine","Vieillissement","Prévention cardiovasculaire","Cardiovascular diseases","Statin","Aging","Cardiovascular prevention"],"languages":["fr"],"rights":[],"rights_urls":["http://creativecommons.org/licenses/by-nc-nd/2.5/ca/"],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11143/19246","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Khalil, Abdelouahed","Fülöp, Tamas"]},{"key":"dc:creator","label":"Author","values":["Mathlouthi, Mohamed"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2022-05-27T14:27:58Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2022-05-27T14:27:58Z"]},{"key":"dc:date.issued","label":"Date","values":["2022"]},{"key":"dc:publisher","label":"Institution","values":["Université de Sherbrooke"]},{"key":"dc:type","label":"Dc Type","values":["Mémoire de maîtrise"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Sciences cliniques"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Maîtrise"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M. Sc."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Faculté de médecine et des sciences de la santé"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Maladies cardiovasculaires","Statine","Vieillissement","Prévention cardiovasculaire","Cardiovascular diseases","Statin","Aging","Cardiovascular prevention"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["fr"]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://creativecommons.org/licenses/by-nc-nd/2.5/ca/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11143/19246"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Introduction: As the population ages the rate of cardiovascular events is continually increasing. Compared to younger, people aged 75 and over are three times more susceptible to cardiovascular complications. According to Canadian guidelines statins are recommended for the prevention of cardiovascular diseases. However, the effects of statins in preventing cardiovascular events in people aged 75 and over remain unclear. In addition, this population is often absent or underrepresented in most studies. Objective: Our research aim was to study the association between the use of statins and the occurrence of angina, myocardial infarction and stroke in people aged 75 years and older. Methods: In this retrospective cohort study, we used the database of the CIRESSS (Computerized Center for Evaluative Research in Health Services and Care) at the University Hospital of Sherbrooke (Quebec, Canada) (CHUS). 4089 men and women aged 75 and over, admitted to the Sherbrooke University Hospital and recorded in the electronic medical records (Ariane) between 2007 and 2017, were classified into two groups: those who used the statin (GS) and those who did not (GNS). The effect of statin use on the occurrence of myocardial infarction, angina or stroke was analyzed using logistic regression. Results: 143 angina incidents were recorded in the GS group compared to 53 events in the GNS group (OR 3.37 ; 2.26-5.07 ; p <0.001). There were 435 myocardial infarction occurrences in the GS group compared to 157 in the GNS group (OR 4.43 ; 3.44-5.71 ; p <0.001). Regarding stroke, it was higher in the GS group at 9.32% compared to 5.93% in the GNS group with no signification (OR 0.74 ; 0.53-1.02 ; p=0.0676). Conclusion: The use of statins was significantly associated with the increased risk for coronary heart disease. However, no significant effect was observed on the stroke.","Introduction : Parallèlement au vieillissement de la population, le taux des évènements cardiovasculaires augmente significativement. Comparées aux plus jeunes, les personnes âgées de 75 ans et plus sont trois fois plus à risque des complications cardiovasculaires. Selon les lignes directrices canadiennes, les statines sont recommandées pour la prévention des maladies cardiovasculaires chez les personnes de tous âges. Cependant, les effets des statines dans la prévention des évènements cardiovasculaires chez les personnes âgées de 75 ans et plus demeurent flous. En plus, cette population est souvent absente ou sous-représentée dans les études. Objectifs : Notre objectif de recherche a été d’étudier l’association entre l’utilisation des statines et la survenue d’angine de poitrine, d’infarctus du myocarde et d’AVC chez des personnes âgées de 75 ans et plus. Méthodologie : Dans cette étude de type cohorte rétrospective, nous avons utilisé la base de données du CIRESSS (Centre Informatisé De Recherche Évaluative En Services Et Soins De Santé) à l'Hôpital Universitaire de Sherbrooke (Québec, Canada) (CHUS). La population d’étude a été composée de 4089 hommes et femmes âgés de 75 ans et plus, admis à l'hôpital universitaire de Sherbrooke et enregistrés dans les dossiers médicaux électroniques (Ariane) entre 2007 et 2017. Nos participants ont été répartis en deux groupes selon l’utilisation (GS) ou non (GNS) des statines. L’effet de l'utilisation des statines sur la survenue de l’infarctus du myocarde, l’angine de poitrine ou l’AVC a été analysé en utilisant la régression logistique. Résultats : Nous avons noté 143 angines de poitrine au groupe GS comparés à 53 au groupe GNS avec un (OR 3.37 ; 2.26-5.07 ; p<0.001). 435 cas d’infarctus du myocarde ont été enregistrés dans le groupe GS comparés à 157 dans le groupe GNS avec un (OR 4.43 ; 3.44-5.71 ; p<0.001). En ce qui concerne les AVC, ils ont été plus élevés dans le groupe GS soit 9.32% comparé à 5.93% au groupe GNS avec un OR non significatif de 0.74 (0.53-1.02 ; p=0.0676). Conclusion : L’utilisation des statines a été significativement associée au risque des maladies coronariennes. Par contre, aucun effet significatif n’a été observé sur l’AVC."]},{"key":"dc:title","label":"Title","values":["Effet des statines sur les maladies cardiovasculaires chez les personnes âgées de 75 ans et plus"]}]}],"canonical_facts":{"dc:contributor.advisor":["Khalil, Abdelouahed","Fülöp, Tamas"],"dc:creator":["Mathlouthi, Mohamed"],"dc:date.accessioned":["2022-05-27T14:27:58Z"],"dc:date.available":["2022-05-27T14:27:58Z"],"dc:date.issued":["2022"],"dc:description.abstract":["Introduction: As the population ages the rate of cardiovascular events is continually increasing. Compared to younger, people aged 75 and over are three times more susceptible to cardiovascular complications. According to Canadian guidelines statins are recommended for the prevention of cardiovascular diseases. However, the effects of statins in preventing cardiovascular events in people aged 75 and over remain unclear. In addition, this population is often absent or underrepresented in most studies. Objective: Our research aim was to study the association between the use of statins and the occurrence of angina, myocardial infarction and stroke in people aged 75 years and older. Methods: In this retrospective cohort study, we used the database of the CIRESSS (Computerized Center for Evaluative Research in Health Services and Care) at the University Hospital of Sherbrooke (Quebec, Canada) (CHUS). 4089 men and women aged 75 and over, admitted to the Sherbrooke University Hospital and recorded in the electronic medical records (Ariane) between 2007 and 2017, were classified into two groups: those who used the statin (GS) and those who did not (GNS). The effect of statin use on the occurrence of myocardial infarction, angina or stroke was analyzed using logistic regression. Results: 143 angina incidents were recorded in the GS group compared to 53 events in the GNS group (OR 3.37 ; 2.26-5.07 ; p <0.001). There were 435 myocardial infarction occurrences in the GS group compared to 157 in the GNS group (OR 4.43 ; 3.44-5.71 ; p <0.001). Regarding stroke, it was higher in the GS group at 9.32% compared to 5.93% in the GNS group with no signification (OR 0.74 ; 0.53-1.02 ; p=0.0676). Conclusion: The use of statins was significantly associated with the increased risk for coronary heart disease. However, no significant effect was observed on the stroke.","Introduction : Parallèlement au vieillissement de la population, le taux des évènements cardiovasculaires augmente significativement. Comparées aux plus jeunes, les personnes âgées de 75 ans et plus sont trois fois plus à risque des complications cardiovasculaires. Selon les lignes directrices canadiennes, les statines sont recommandées pour la prévention des maladies cardiovasculaires chez les personnes de tous âges. Cependant, les effets des statines dans la prévention des évènements cardiovasculaires chez les personnes âgées de 75 ans et plus demeurent flous. En plus, cette population est souvent absente ou sous-représentée dans les études. Objectifs : Notre objectif de recherche a été d’étudier l’association entre l’utilisation des statines et la survenue d’angine de poitrine, d’infarctus du myocarde et d’AVC chez des personnes âgées de 75 ans et plus. Méthodologie : Dans cette étude de type cohorte rétrospective, nous avons utilisé la base de données du CIRESSS (Centre Informatisé De Recherche Évaluative En Services Et Soins De Santé) à l'Hôpital Universitaire de Sherbrooke (Québec, Canada) (CHUS). La population d’étude a été composée de 4089 hommes et femmes âgés de 75 ans et plus, admis à l'hôpital universitaire de Sherbrooke et enregistrés dans les dossiers médicaux électroniques (Ariane) entre 2007 et 2017. Nos participants ont été répartis en deux groupes selon l’utilisation (GS) ou non (GNS) des statines. L’effet de l'utilisation des statines sur la survenue de l’infarctus du myocarde, l’angine de poitrine ou l’AVC a été analysé en utilisant la régression logistique. Résultats : Nous avons noté 143 angines de poitrine au groupe GS comparés à 53 au groupe GNS avec un (OR 3.37 ; 2.26-5.07 ; p<0.001). 435 cas d’infarctus du myocarde ont été enregistrés dans le groupe GS comparés à 157 dans le groupe GNS avec un (OR 4.43 ; 3.44-5.71 ; p<0.001). En ce qui concerne les AVC, ils ont été plus élevés dans le groupe GS soit 9.32% comparé à 5.93% au groupe GNS avec un OR non significatif de 0.74 (0.53-1.02 ; p=0.0676). Conclusion : L’utilisation des statines a été significativement associée au risque des maladies coronariennes. Par contre, aucun effet significatif n’a été observé sur l’AVC."],"dc:identifier.uri":["http://hdl.handle.net/11143/19246"],"dc:language.iso":["fr"],"dc:publisher":["Université de Sherbrooke"],"dc:rights.uri":["http://creativecommons.org/licenses/by-nc-nd/2.5/ca/"],"dc:subject":["Maladies cardiovasculaires","Statine","Vieillissement","Prévention cardiovasculaire","Cardiovascular diseases","Statin","Aging","Cardiovascular prevention"],"dc:title":["Effet des statines sur les maladies cardiovasculaires chez les personnes âgées de 75 ans et plus"],"dc:type":["Mémoire de maîtrise"],"thesis:degree_discipline":["Sciences cliniques"],"thesis:degree_level":["Maîtrise"],"thesis:degree_name":["M. Sc."],"thesis:institution_name":["Faculté de médecine et des sciences de la santé"]},"updated_at":"2026-07-27T21:07:34Z"}