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University of Saskatchewan
ALDOL COUPLINGS OF CHIRAL FRAGMENTS WITH KINETIC RESOLUTION: SCOPE AND LIMITATIONS
Abstract
dc:description.abstract“The Thiopyran Route to Polypropionates” is a synthetic strategy that involves the stepwise aldol reactions of 6 and 7a to rapidly access stereochemically complex tetrapropionate 8 and hexapropionate synthons 72 or 73. Coupling racemic 7a with any of the four enantioenriched diastereomers 8 with kinetic resolution (KR) is possible with rational design of the reaction using the 'multiplicativity' rule. Thus, any of two of the eight possible aldol adducts, 72 or 73, are selectively available from the same reactants.
Degree
thesis:*- Name thesis:degree_name
- Master of Science (M.Sc.)
- Level thesis:degree_level
- Masters
- Discipline thesis:degree_discipline
- Chemistry
- Grantor
- University of Saskatchewan
- Year dc:date.issued
- 2013
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- kazemeini, alieh
- Advisor dc:contributor.advisor
-
- Ward, Dale
- Committee members dc:contributor.committeemember
-
- Majewski, Marek
- Gravel, Michel
- Attah-Poku, Samuel
Subjects
dc:subject × 1Rights
- Language dc:language.iso
- eng
Identifiers
dc:identifier.*- Handle dc:identifier.uri
- https://hdl.handle.net/10388/ETD-2011-12-244
- OAI identifier oai:identifier
- oai:harvest.usask.ca:10388/ETD-2011-12-244