THE SYNTHESIS AND CHELATION OF SOME AZOPYRIMIDINES

Numerous azo compounds have been shown in the past to have either a stimulating or inhibiting effect on tumour growth* The first recorded observation of the production of tumor-like proliferations was made by Fisher in 1906, who described the atypical epithelial proliferations which re-sulted from injections of scarlet red into the ears of rab-bits Cl). Since the pyrimidine nucleus is an important com-ponent of many biological systems, many pyrirnidine derive-tives have been found with a considerable degree of pharma-cologic activity and have attained a wide ,use in medicine in such drugs as the barbituric hypnotics, antithyroid agente; the sulphas and vitamins, to mention only a few. More re-cently, attempts to find anti-carcinogenic substances have moved into the field of pyrimidine and purine chemistry be-cause of their importance in cell constituents in the form of nucleic acids. Many of them .have been found to have in-hibitory effects on tumor growth both. in vitro and in vivo. Metal chelates have been suggested as a method of introducing or removing metals to and from various tissues and systems. The toxicity to enzymes and fungi of metal chelating agents has been postulated to be due to the removal of essential metals (2,3,4)0 and certain metal chelate them-selves have been shown to be active pharmacologicaily Re-moval of inorganic metallic carcinogens could" thus be possible through the use of chelating agents. From the preceding brief description, by combining the pyrimidine nucleus in an azo compound of such a nature that a chelating agent would result, it is thought that a compound with tumor-inhibiting properties could be synthe-sized. Accordingly, this investigation was undertaken to synthesize azopyrimidines, with mono-,ortho and di—ortho hydroxy groups with respect to the azo linkage, to form vari—ous metal chelates of the synthesized azopyrimidines, and to attempt to ascertain a structure for the chelated compounds.

Name thesis:degree_name

Master of Science (M.Sc.)

Level thesis:degree_level

Masters

Grantor

University of Saskatchewan

Year dc:date.issued

1960

Author dc:creator

• Alexander, William Edward Lewis

Advisor dc:contributor.advisor

• Jeffrey, J.G.

• Metal chelates
• azo compound
• tumor-inhibiting properties

Handle dc:identifier.uri

https://hdl.handle.net/10388/15309

OAI identifier oai:identifier

oai:harvest.usask.ca:10388/15309