DERIVATIVES OF 1-PHENYL-1-NONEN-3-ONE AS POTENTIAL BIOLOGICAL ALKYLATING AGENTS
type: CreativeWork
description: The-preparation, spectroscopic properties and antineoplastic activities of a series of alkyl styryl ketones are presented. Unsaturated ketones are known to have alkylating properties. 1-Phenyl-1-nonen-3-one (51) and nuclear substituted derivatives were prepared as potential biological alkylating agents. The influence of aromatic substituents and the length of the alkyl side chain in relation to biological activity was undertaken. The olefinic bonds in the series of 1-(substituted phenyl)-1-nonen-3-ones had the E configuration. Infrared spectroscopy was useful for detecting mixtures of s-cis and s-trans rotational isomers.
abstract: The-preparation, spectroscopic properties and antineoplastic activities of a series of alkyl styryl ketones are presented. Unsaturated ketones are known to have alkylating properties. 1-Phenyl-1-nonen-3-one (51) and nuclear substituted derivatives were prepared as potential biological alkylating agents. The influence of aromatic substituents and the length of the alkyl side chain in relation to biological activity was undertaken. The olefinic bonds in the series of 1-(substituted phenyl)-1-nonen-3-ones had the E configuration. Infrared spectroscopy was useful for detecting mixtures of s-cis and s-trans rotational isomers.
author: Taylor, Wesley Gordon
keywords: alkylating agents, 1-PHENYL-1-NONEN-3-ONE
date published: 1973
date modified: 2026-07-24T04:27:13Z
provider: University of Saskatchewan
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Saskatchewan

PropertyValue
property ID: Handle
value: https://hdl.handle.net/10388/15284