{"id":{"repo_id":"sask","oai_identifier":"oai:harvest.usask.ca:10388/15284"},"canonical_url":"https://search.dev.ndltd.org/etd/sask/oai:harvest.usask.ca:10388/15284","repository":{"repo_id":"sask","name":"University of Saskatchewan","base_url":"https://harvest.usask.ca/server/oai/request"},"display":{"title":"DERIVATIVES OF 1-PHENYL-1-NONEN-3-ONE AS POTENTIAL BIOLOGICAL ALKYLATING AGENTS","abstract":"The-preparation, spectroscopic properties and antineoplastic activities of a series of alkyl styryl ketones are presented. Unsaturated ketones are known to have alkylating properties. 1-Phenyl-1-nonen-3-one (51) and nuclear substituted derivatives were prepared as potential biological alkylating agents. The influence of aromatic substituents and the length of the alkyl side chain in relation to biological activity was undertaken. The olefinic bonds in the series of 1-(substituted phenyl)-1-nonen-3-ones had the E configuration. Infrared spectroscopy was useful for detecting mixtures of s-cis and s-trans rotational isomers.","abstract_html":"The-preparation, spectroscopic properties and antineoplastic activities of a series of alkyl styryl ketones are presented. Unsaturated ketones are known to have alkylating properties. 1-Phenyl-1-nonen-3-one (51) and nuclear substituted derivatives were prepared as potential biological alkylating agents. The influence of aromatic substituents and the length of the alkyl side chain in relation to biological activity was undertaken. The olefinic bonds in the series of 1-(substituted phenyl)-1-nonen-3-ones had the E configuration. Infrared spectroscopy was useful for detecting mixtures of s-cis and s-trans rotational isomers.","abstract_has_math":false,"creators":["Taylor, Wesley Gordon"],"institution":"University of Saskatchewan","degree_name":"Doctor of Philosophy (Ph.D.)","degree_level":"Doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1973,"date_issued":"1973","date_published":"1973","updated_at":"2026-07-24T04:27:13Z","subjects":["alkylating agents","1-PHENYL-1-NONEN-3-ONE"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/10388/15284","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Taylor, Wesley Gordon"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2023-11-20T18:18:55Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2023-11-20T18:18:55Z"]},{"key":"dc:date.issued","label":"Date","values":["1973"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Doctoral"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (Ph.D.)"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Saskatchewan"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["alkylating agents","1-PHENYL-1-NONEN-3-ONE"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10388/15284"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The-preparation, spectroscopic properties and antineoplastic activities of a series of alkyl styryl ketones are presented. Unsaturated ketones are known to have alkylating properties. 1-Phenyl-1-nonen-3-one (51) and nuclear substituted derivatives were prepared as potential biological alkylating agents. The influence of aromatic substituents and the length of the alkyl side chain in relation to biological activity was undertaken. The olefinic bonds in the series of 1-(substituted phenyl)-1-nonen-3-ones had the E configuration. Infrared spectroscopy was useful for detecting mixtures of s-cis and s-trans rotational isomers."]},{"key":"dc:title","label":"Title","values":["DERIVATIVES OF 1-PHENYL-1-NONEN-3-ONE AS POTENTIAL BIOLOGICAL ALKYLATING AGENTS"]}]}],"canonical_facts":{"dc:creator":["Taylor, Wesley Gordon"],"dc:date.accessioned":["2023-11-20T18:18:55Z"],"dc:date.available":["2023-11-20T18:18:55Z"],"dc:date.issued":["1973"],"dc:description.abstract":["The-preparation, spectroscopic properties and antineoplastic activities of a series of alkyl styryl ketones are presented. Unsaturated ketones are known to have alkylating properties. 1-Phenyl-1-nonen-3-one (51) and nuclear substituted derivatives were prepared as potential biological alkylating agents. The influence of aromatic substituents and the length of the alkyl side chain in relation to biological activity was undertaken. The olefinic bonds in the series of 1-(substituted phenyl)-1-nonen-3-ones had the E configuration. Infrared spectroscopy was useful for detecting mixtures of s-cis and s-trans rotational isomers."],"dc:identifier.uri":["https://hdl.handle.net/10388/15284"],"dc:subject":["alkylating agents","1-PHENYL-1-NONEN-3-ONE"],"dc:title":["DERIVATIVES OF 1-PHENYL-1-NONEN-3-ONE AS POTENTIAL BIOLOGICAL ALKYLATING AGENTS"],"thesis:degree_level":["Doctoral"],"thesis:degree_name":["Doctor of Philosophy (Ph.D.)"],"thesis:institution_name":["University of Saskatchewan"]},"updated_at":"2026-07-24T04:27:13Z"}