Synthesis of small-molecule HGF-Met inhibitors for use in preventing cell motility
Glycosaminoglycans are becoming more and more focused upon as a research topic due to the broad use they have in aiding wound healing and preventing cell motility through competitive inhibition of the HGF-Met pathway. This pathway is extremely important in various cellular processes including cancer development, metastasis, tissue regeneration, damage and cell motility. This project aimed to synthesise a series of easily prepared (3 step) mono, di-, tri- and tetra-sulfated glycomimetic compounds for their use in preventing HGF-induced cell motility in cancers, prevention of Met activation and for their beneficial actions in assisting wound healing. Glycosaminoglycans are becoming more and more focused upon as a research topic due to the broad use they have in aiding wound healing and preventing cell motility through competitive inhibition of the HGF-Met pathway. This pathway is extremely important in various cellular processes including cancer development, metastasis, tissue regeneration, damage and cell motility. This project aimed to synthesise a series of easily prepared (3 step) mono, di-, tri- and tetra-sulfated glycomimetic compounds for their use in preventing HGF-induced cell motility in cancers, prevention of Met activation and for their beneficial actions in assisting wound healing. Overall, several of the sulfated glycomimetic compounds synthesised in this project show promising activity in inhibiting the HGF/Met pathway, although more work is required to further optimise the SAR and assure effective inhibition.
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