{"id":{"repo_id":"salamanca","oai_identifier":"oai:gredos.usal.es:10366/76235"},"canonical_url":"https://search.dev.ndltd.org/etd/salamanca/oai:gredos.usal.es:10366/76235","repository":{"repo_id":"salamanca","name":"Universidad de Salamanca","base_url":"https://gredos.usal.es/oai/request"},"display":{"title":"Función de la E3 Ubiquitina Ligasa Apc/Ccdh1 en la Diferenciación Neuronal Inducida por Ácido Retinoico","abstract":"[ES] En esta Tesis se ha Investigado el efecto del RA sobre la expresión de p27 y Skp2 en células de neuroblastoma humano, se ha Estudiado la función de la E3 ubiquitina ligasa APC/C-Cdh1 en los efectos antiproliferativos y neurogénicos del RA y se ha Dilucidado los mecanismos que regulan la actividad de APC/C-Cdh1 durante la diferenciación neuronal.","abstract_html":"[ES] En esta Tesis se ha Investigado el efecto del RA sobre la expresión de p27 y Skp2 en células de neuroblastoma humano, se ha Estudiado la función de la E3 ubiquitina ligasa APC/C-Cdh1 en los efectos antiproliferativos y neurogénicos del RA y se ha Dilucidado los mecanismos que regulan la actividad de APC/C-Cdh1 durante la diferenciación neuronal.","abstract_has_math":false,"creators":["Cuende Villasur, Julia"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2009,"date_issued":"2009","date_published":"2009","updated_at":"2026-07-27T20:51:51Z","subjects":["Tesis y disertaciones académicas","Universidad de Salamanca (España)","Academic dissertations","Retinoblastoma","Sistema nervioso","Nervous system","Ciclo celular","Mitosis"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:10366/76235"],"render_values":[{"text":"hdl:10366/76235","href":null,"code":true}]}]},"links":{"outbound_url":"https://doi.org/10.14201/gredos.76235","outbound_label":"DOI","outbound_source":"dc:identifier.doi"},"metadata_groups":[{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["2009"]},{"key":"dc:type","label":"Dc Type","values":["info:eu-repo/semantics/doctoralThesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Tesis y disertaciones académicas","Universidad de Salamanca (España)","Academic dissertations","Retinoblastoma","Sistema nervioso","Nervous system","Ciclo celular","Mitosis"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:10366/76235"]},{"key":"dc:identifier.doi","label":"DOI","values":["10.14201/gredos.76235"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.other","label":"Dc Description Other","values":["[ES] En esta Tesis se ha Investigado el efecto del RA sobre la expresión de p27 y Skp2 en células de neuroblastoma humano, se ha Estudiado la función de la E3 ubiquitina ligasa APC/C-Cdh1 en los efectos antiproliferativos y neurogénicos del RA y se ha Dilucidado los mecanismos que regulan la actividad de APC/C-Cdh1 durante la diferenciación neuronal.","[EN] This thesis investigated the effect of RA on the expression of p27 and Skp2 in the human neuroblastoma cells, we studied the role of the E3 ubiquitin ligase APC/C-Cdh1 in proliferative and neurogenic effects of RA and has been elucidated the mechanisms that regulate the activity of APC/C-Cdh1 during neuronal differentiation."]},{"key":"dc:title","label":"Title","values":["Función de la E3 Ubiquitina Ligasa Apc/Ccdh1 en la Diferenciación Neuronal Inducida por Ácido Retinoico"]}]}],"canonical_facts":{"dc:date.issued":["2009"],"dc:description.other":["[ES] En esta Tesis se ha Investigado el efecto del RA sobre la expresión de p27 y Skp2 en células de neuroblastoma humano, se ha Estudiado la función de la E3 ubiquitina ligasa APC/C-Cdh1 en los efectos antiproliferativos y neurogénicos del RA y se ha Dilucidado los mecanismos que regulan la actividad de APC/C-Cdh1 durante la diferenciación neuronal.","[EN] This thesis investigated the effect of RA on the expression of p27 and Skp2 in the human neuroblastoma cells, we studied the role of the E3 ubiquitin ligase APC/C-Cdh1 in proliferative and neurogenic effects of RA and has been elucidated the mechanisms that regulate the activity of APC/C-Cdh1 during neuronal differentiation."],"dc:identifier":["hdl:10366/76235"],"dc:identifier.doi":["10.14201/gredos.76235"],"dc:subject":["Tesis y disertaciones académicas","Universidad de Salamanca (España)","Academic dissertations","Retinoblastoma","Sistema nervioso","Nervous system","Ciclo celular","Mitosis"],"dc:title":["Función de la E3 Ubiquitina Ligasa Apc/Ccdh1 en la Diferenciación Neuronal Inducida por Ácido Retinoico"],"dc:type":["info:eu-repo/semantics/doctoralThesis"]},"updated_at":"2026-07-27T20:51:51Z"}