Caracterización de variantes genéticas implicadas en la susceptibilidad a desarrollar carcinomas escamosos de cabeza y cuello. Correlación clínica

[EN] Crowd of exogenous agents (snuff , alcohol ,ultraviolet radiation, etc.) And endogenous agents (hydrogen peroxide, reactive oxygen molecules , etc.) can cause DNA damage. Polymorphisms in DNA repair genes may alter the ability to repair DNA damage, lead to genetic instability and carcinogenesis. Furthermore, considering that cancer treatments are often based on the induction of DNA damage , polymorphisms in repair pathways could be important for treatment response , toxicity and survival. Moreover, numerous studies show that the allelic variant of codon 72 of P53 has different functional activity in the induction of apoptosis , an essential mechanism behind the failure of repair systems . In this context we consider the following objectives: 1 - . Study , in patients diagnosed with head and neck cancer, the presence of allelic variants in DNA repair genes ( XRCC1_rs25487 , APEX_rs1130409 , XPD_rs13181 , ERCC1_rs11615 , XRCC3_rs861539 ) and p53 codon 72 ( rs1042522 ) , which may alter the risk of developing the disease. 2 - . To analyze the possible involvement of these allelic variants in disease-free survival , response to treatment and the occurrence of side effects in patients with head and neck tumors.

Author

• Seijas Tamayo, Raquel

• Academic dissertations
• Clinical oncology
• Tesis y disertaciones académicas
• Universidad de Salamanca (España)
• Oncología clínica

Identifier

hdl:10366/123056

OAI identifier oai:identifier

oai:gredos.usal.es:10366/123056