{"id":{"repo_id":"salamanca","oai_identifier":"oai:gredos.usal.es:10366/110631"},"canonical_url":"https://search.dev.ndltd.org/etd/salamanca/oai:gredos.usal.es:10366/110631","repository":{"repo_id":"salamanca","name":"Universidad de Salamanca","base_url":"https://gredos.usal.es/oai/request"},"display":{"title":"Estudio clínico y molecular de acalasia esofágica","abstract":"[EN] The objectives of this thesis are: - Learn about the evolution of patients diagnosed with achalasia, as has been treated with botulinum toxin injection, pneumatic dilation or surgery. - Evaluate the potential response to treatments in clinical terms, manometric and radiological barium transit through. - To compare the efficacy of different therapeutic strategies. - To establish the involvement of proinflammatory cytokines (IL-6, IL-4, TNFa), nitric oxide synthase, endothelin-1 and PPAR (Peroxisome proliferator activated receptor gamma) in the etiopathogenesis of achalasia and its association with the form presentation or dela disease evolution.","abstract_html":"[EN] The objectives of this thesis are: - Learn about the evolution of patients diagnosed with achalasia, as has been treated with botulinum toxin injection, pneumatic dilation or surgery. - Evaluate the potential response to treatments in clinical terms, manometric and radiological barium transit through. - To compare the efficacy of different therapeutic strategies. - To establish the involvement of proinflammatory cytokines (IL-6, IL-4, TNFa), nitric oxide synthase, endothelin-1 and PPAR (Peroxisome proliferator activated receptor gamma) in the etiopathogenesis of achalasia and its association with the form presentation or dela disease evolution.","abstract_has_math":false,"creators":["Tejedor Cerdeña, María Auxiliadora"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011","date_published":"2011","updated_at":"2026-07-27T20:57:03Z","subjects":["Tesis y disertaciones académicas","Universidad de Salamanca (España)","Tesis Doctoral","Academic dissertations","Acalasia esofágica","Esophageal achalasia","Enfermos","Patients sick"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:10366/110631"],"render_values":[{"text":"hdl:10366/110631","href":null,"code":true}]}]},"links":{"outbound_url":"https://doi.org/10.14201/gredos.110631","outbound_label":"DOI","outbound_source":"dc:identifier.doi"},"metadata_groups":[{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["2011"]},{"key":"dc:type","label":"Dc Type","values":["info:eu-repo/semantics/doctoralThesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Tesis y disertaciones académicas","Universidad de Salamanca (España)","Tesis Doctoral","Academic dissertations","Acalasia esofágica","Esophageal achalasia","Enfermos","Patients sick"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:10366/110631"]},{"key":"dc:identifier.doi","label":"DOI","values":["10.14201/gredos.110631"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.other","label":"Dc Description Other","values":["[EN] The objectives of this thesis are: - Learn about the evolution of patients diagnosed with achalasia, as has been treated with botulinum toxin injection, pneumatic dilation or surgery. - Evaluate the potential response to treatments in clinical terms, manometric and radiological barium transit through. - To compare the efficacy of different therapeutic strategies. - To establish the involvement of proinflammatory cytokines (IL-6, IL-4, TNFa), nitric oxide synthase, endothelin-1 and PPAR (Peroxisome proliferator activated receptor gamma) in the etiopathogenesis of achalasia and its association with the form presentation or dela disease evolution.","[ES] Los objetivos de esta tesis doctoral son: - Conocer la evolución de los pacientes diagnosticados de acalasia, según hayan sido tratados con inyección de toxina botulínica, dilatación neumática o cirugía. - Evaluar la respuesta a los posibles tratamientos en términos clínicos, manométricos y radiológicos mediante el tránsito baritado. - Comparar la eficacia de las diferentes estrategias terapéuticas. - Establecer la implicación de citocinas proinflamatorias (IL-6, IL-4, TNFα), la sintasa del óxido nítrico, la endotelina 1 y el PPARγ (Peroxisome proliferator activated receptor gamma) en la etiopatogénesis de la acalasia y su asociación con la forma de presentación o la evolución dela enfermedad."]},{"key":"dc:title","label":"Title","values":["Estudio clínico y molecular de acalasia esofágica"]}]}],"canonical_facts":{"dc:date.issued":["2011"],"dc:description.other":["[EN] The objectives of this thesis are: - Learn about the evolution of patients diagnosed with achalasia, as has been treated with botulinum toxin injection, pneumatic dilation or surgery. - Evaluate the potential response to treatments in clinical terms, manometric and radiological barium transit through. - To compare the efficacy of different therapeutic strategies. - To establish the involvement of proinflammatory cytokines (IL-6, IL-4, TNFa), nitric oxide synthase, endothelin-1 and PPAR (Peroxisome proliferator activated receptor gamma) in the etiopathogenesis of achalasia and its association with the form presentation or dela disease evolution.","[ES] Los objetivos de esta tesis doctoral son: - Conocer la evolución de los pacientes diagnosticados de acalasia, según hayan sido tratados con inyección de toxina botulínica, dilatación neumática o cirugía. - Evaluar la respuesta a los posibles tratamientos en términos clínicos, manométricos y radiológicos mediante el tránsito baritado. - Comparar la eficacia de las diferentes estrategias terapéuticas. - Establecer la implicación de citocinas proinflamatorias (IL-6, IL-4, TNFα), la sintasa del óxido nítrico, la endotelina 1 y el PPARγ (Peroxisome proliferator activated receptor gamma) en la etiopatogénesis de la acalasia y su asociación con la forma de presentación o la evolución dela enfermedad."],"dc:identifier":["hdl:10366/110631"],"dc:identifier.doi":["10.14201/gredos.110631"],"dc:subject":["Tesis y disertaciones académicas","Universidad de Salamanca (España)","Tesis Doctoral","Academic dissertations","Acalasia esofágica","Esophageal achalasia","Enfermos","Patients sick"],"dc:title":["Estudio clínico y molecular de acalasia esofágica"],"dc:type":["info:eu-repo/semantics/doctoralThesis"]},"updated_at":"2026-07-27T20:57:03Z"}