Automated segmentation of radiodense tissue in digitized mammograms using a constrained Neyman-Pearson classifier

<p>Breast cancer is the second leading cause of cancer related mortality among American women. Mammography screening has emerged as a reliable non-invasive technique for early detection of breast cancer. The radiographic appearance of the female breast consists of radiolucent (dark) regions and radiodense (light) regions due to connective and epithelial tissue. It has been established that the percentage of radiodense tissue in a patient's breast can be used as a marker for predicting breast cancer risk. This thesis presents the design, development and validation of a novel automated algorithm for estimating the percentage of radiodense tissue in a digitized mammogram. The technique involves determining a dynamic threshold for segmenting radiodense indications in mammograms. Both the mammographic image and the threshold are modeled as Gaussian random variables and a constrained Neyman-Pearson criteria has been developed for segmenting radiodense tissue. Promising results have been obtained using the proposed technique. Mammograms have been obtained from an existing cohort of women enrolled in the Family Risk Analysis Program at Fox Chase Cancer Center (FCCC). The proposed technique has been validated using a set of ten images with percentages of radiodense tissue, estimated by a trained radiologist using previously established methods. This work is intended to support a concurrent study at the FCCC exploring the association between dietary patterns and breast cancer risk.</p>

Name thesis:degree_name

M.S. in Engineering

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Electrical & Computer Engineering

Year dc:date.available

2002

Author dc:creator

• Neyhart, Jeremy Thomas

Contributors dc:contributor

• Mandayam, Shreekanth

• Breast--Radiography
• Electrical and Computer Engineering

Repository record dc:identifier

https://rdw.rowan.edu/etd/1492

OAI identifier oai:identifier

oai:rdw.rowan.edu:etd-2492