{"id":{"repo_id":"rosario","oai_identifier":"oai:repository.urosario.edu.co:10336/47584"},"canonical_url":"https://search.dev.ndltd.org/etd/rosario/oai:repository.urosario.edu.co:10336/47584","repository":{"repo_id":"rosario","name":"Universidad del Rosario","base_url":"https://repository.urosario.edu.co/oai/request"},"display":{"title":"Desenlaces en pacientes sépticos de una unidad de cuidado intensivo pediátrico con Programa de Optimización de Antimicrobianos (PROA). Clínica Colsubsidio Infantil 2021 - 2023","abstract":"Se realizó un estudio observacional descriptivo de cohorte retrospectiva que incluyó 395 pacientes de 0 a 18 años con diagnóstico de sepsis manejados en la UCIP entre 2021 y 2023. Se describieron características sociodemográficas y clínicas, patrones microbiológicos, mecanismos de resistencia, decisiones antibióticas en el marco del PROA y desenlaces clínicos. Este estudio ofrece una descripción detallada de la sepsis pediátrica en una UCIP de alta complejidad en el contexto de un PROA institucional y proporciona una línea de base local sobre características clínicas, microbiológicas y desenlaces, útil para el ajuste de protocolos y para el diseño de futuras investigaciones analíticas o de implementación.","abstract_html":"Se realizó un estudio observacional descriptivo de cohorte retrospectiva que incluyó 395 pacientes de 0 a 18 años con diagnóstico de sepsis manejados en la UCIP entre 2021 y 2023. Se describieron características sociodemográficas y clínicas, patrones microbiológicos, mecanismos de resistencia, decisiones antibióticas en el marco del PROA y desenlaces clínicos. Este estudio ofrece una descripción detallada de la sepsis pediátrica en una UCIP de alta complejidad en el contexto de un PROA institucional y proporciona una línea de base local sobre características clínicas, microbiológicas y desenlaces, útil para el ajuste de protocolos y para el diseño de futuras investigaciones analíticas o de implementación.","abstract_has_math":false,"creators":["Romero Castro, Héctor Andrés","Cardenas Muller, Adriana"],"institution":"Universidad del Rosario","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2026,"date_issued":"2026-01-15","date_published":"2026-01-15","updated_at":"2026-07-27T20:47:03Z","subjects":["Sepsis","Pediatria","Cuidado intensivo pedaitrico","Programa de optimización de antimicrobianos","Resistencia bacteriana","Pediatric","Pediatric intensive care unit","Antimicrobial stewardship program","Bacterial resistance"],"languages":["spa"],"rights":["info:eu-repo/semantics/openAccess"],"rights_urls":["http://creativecommons.org/licenses/by/4.0/"],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://repository.urosario.edu.co/handle/10336/47584"],"render_values":[{"text":"https://repository.urosario.edu.co/handle/10336/47584","href":"https://repository.urosario.edu.co/handle/10336/47584","code":true}]}]},"links":{"outbound_url":"https://doi.org/10.48713/10336_47584","outbound_label":"DOI","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Romero Castro, Héctor Andrés","Cardenas Muller, Adriana"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2026-01-15","2026-02-25T15:06:06Z"]},{"key":"dc:publisher","label":"Institution","values":["Universidad del Rosario","Escuela de Medicina y Ciencias de la Salud","Especialización en Medicina Crítica y Cuidado Intensivo Pediátrico"]},{"key":"dc:type","label":"Dc Type","values":["info:eu-repo/semantics/masterThesis","info:eu-repo/semantics/acceptedVersion"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Sepsis","Pediatria","Cuidado intensivo pedaitrico","Programa de optimización de antimicrobianos","Resistencia bacteriana","Pediatric","Pediatric intensive care unit","Antimicrobial stewardship program","Bacterial resistance"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["spa"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess","http://creativecommons.org/licenses/by/4.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://doi.org/10.48713/10336_47584","https://repository.urosario.edu.co/handle/10336/47584"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Se realizó un estudio observacional descriptivo de cohorte retrospectiva que incluyó 395 pacientes de 0 a 18 años con diagnóstico de sepsis manejados en la UCIP entre 2021 y 2023. Se describieron características sociodemográficas y clínicas, patrones microbiológicos, mecanismos de resistencia, decisiones antibióticas en el marco del PROA y desenlaces clínicos. Este estudio ofrece una descripción detallada de la sepsis pediátrica en una UCIP de alta complejidad en el contexto de un PROA institucional y proporciona una línea de base local sobre características clínicas, microbiológicas y desenlaces, útil para el ajuste de protocolos y para el diseño de futuras investigaciones analíticas o de implementación.","A retrospective observational cohort study was conducted including 395 patients aged 0–18 years with a diagnosis of sepsis admitted to the PICU between 2021 and 2023. Sociodemographic and clinical characteristics, microbiological patterns, resistance mechanisms, antibiotic decisions within the PROA framework and clinical outcomes were described. This study provides a detailed description of pediatric sepsis in a high-complexity PICU operating within an institutional antimicrobial stewardship program and offers a local baseline on clinical and microbiological characteristics and outcomes, which may inform protocol refinement and the design of future analytical or implementation studies."]},{"key":"dc:format","label":"Dc Format","values":["61 pp","application/pdf"]},{"key":"dc:source","label":"Dc Source","values":["Aizawa, Y., Suwa, J., Higuchi, H., Tazumi, K., & Takeuchi, M. (2018). Antimicrobial stewardship program in a pediatric intensive care unit of a tertiary care center in Japan. Journal of the Pediatric Infectious Diseases Society, 7(3), e156–e159.","Antimicrobial Resistance Collaborators. (2023). The burden of antimicrobial resistance in the Americas in 2019: A cross-country systematic analysis. The Lancet Regional Health – Americas, 25, 100561.","Berezin, E. N., & Solórzano, F. (2014). Gram-negative infections in pediatric and neonatal intensive care units of Latin America. Journal of Infection in Developing Countries, 8(8), 942–953.","Cornistein, W., Ferrero, F., Uez, O., Speranza, N., Ardiles, R., & Ferraro, M. (2025). Prevalence and associated mortality of infections by multidrug-resistant organisms in children: A multicenter study in Latin America. Antibiotics, 14(5), 493","Fernández-Polo, A., Melendo-Pérez, S., Larrosa, N., et al. (2024). Five-year evaluation of a pediatric antimicrobial stewardship program in a tertiary-care hospital. Antibiotics, 13(6), 511","Fleischmann-Struzek, C., Goldfarb, D. M., Schlattmann, P., Schlapbach, L. J., Reinhart, K., & Kissoon, N. (2018). The global burden of paediatric and neonatal sepsis: A systematic review. The Lancet Respiratory Medicine, 6(3), 223–230.","Fonseca-Rivera, I. C., et al. (2025). Impact of an antimicrobial stewardship program on mortality and consumption of antibiotics in the intensive care units of a pediatric referral hospital in Peru. Antimicrobial Stewardship & Healthcare Epidemiology, 5(1)","Liberati, C., Brigadoi, G., et al. (2025). Antimicrobial stewardship programs in pediatric intensive care units: A systematic scoping review. Antibiotics, 14(2), 130.","Massaud-Ribeiro, L., Martinez, E. E., & Schlapbach, L. J. (2022). Pediatric sepsis research: Where are we and where are we headed? Frontiers in Pediatrics, 10, 829119.","Ministerio de Salud y Protección Social. (2017). La resistencia a los antimicrobianos: Un reto para los sistemas de salud. Ministerio de Salud y Protección Social de Colombia.","Renk, H., Regamey, N., Hitzler, M., et al. (2020). Antibiotic stewardship in the PICU: Impact of ward rounds led by pediatric infectious diseases specialists on antibiotic use. Scientific Reports, 10, 13717.","Robledo, J., Maldonado, N., Robledo, C., et al. (2022). Changes in antimicrobial resistance and etiology of blood culture isolates: Results of a decade (2010–2019) of surveillance in a northern region of Colombia. Infection and Drug Resistance, 15, 6067–6079.","Rudd, K. E., Johnson, S. C., Agesa, K. M., et al. (2020). Global, regional, and national sepsis incidence and mortality, 1990–2017: Analysis for the Global Burden of Disease Study. The Lancet, 395(10219), 200–211","Sanchez-Pinto, L. N., Schlapbach, L. J., et al. (2024). International consensus criteria for pediatric sepsis and septic shock (Phoenix criteria). JAMA, 331","Sick-Samuels, A. C., et al. (2022). Diagnostic stewardship in the pediatric intensive care unit. Current Treatment Options in Infectious Diseases, 14(1), 54–67","Watson, R. S., Carrol, E. D., Carter, M. J., et al. (2024). The burden and contemporary epidemiology of sepsis in children. The Lancet Child & Adolescent Health, 8(9), 670–681. https://doi.org/10.1016/S2352-4642(24)00135-9","Weiss, S. L., Peters, M. J., Alhazzani, W., et al. (2020). Surviving Sepsis Campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Medicine, 46(Suppl 1), 10–67","Willems, J., Hermans, E., Schelstraete, P., Depuydt, P., & De Cock, P. (2021). Optimizing the use of antibiotic agents in the pediatric intensive care unit: A narrative review. Pediatric Drugs, 23(1), 39–53.","Donà, D., Barbieri, E., Daverio, M., Lundin, R., Giaquinto, C., Zaoutis, T., & Sharland, M. (2020). Implementation and impact of pediatric antimicrobial stewardship programs: A systematic scoping review. Antimicrobial Resistance & Infection Control, 9, 3","Gaies, M. G., Gurney, J. G., Yen, A. H., et al. (2010). Vasoactive-Inotropic Score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass. Pediatric Critical Care Medicine, 11(2), 234–238","Hersh, A. L., Beekmann, S. E., Polgreen, P. M., Zaoutis, T. E., & Newland, J. G. (2013). Antimicrobial stewardship programs in pediatrics. Infectious Disease Clinics of North America, 27(1), 283–298","Newland, J. G., & Gerber, J. S. (2013). Pediatric antimicrobial stewardship programs. Infectious Disease Clinics of North America, 27(1), 91–116","Selewski, D. T., Cornell, T. T., Heung, M., Troost, J. P., Ehrmann, B. J., Lombel, R. M., Shanley, T. P., et al. (2014). Validation of the KDIGO acute kidney injury criteria in a pediatric critical care population. Intensive Care Medicine, 40(10), 1481–1488","Shah, P., et al. (2022). Using aggregate vasoactive-inotrope scores to predict outcomes in pediatric sepsis. Frontiers in Pediatrics, 10, 778378","Tamma, P. D., Aitken, S. L., Bonomo, R. A., Mathers, A. J., van Duin, D., & Clancy, C. J. (2021). IDSA guidance on the treatment of AmpC β-lactamase–producing Enterobacterales, carbapenem-resistant Enterobacterales, and Pseudomonas aeruginosa with difficult-to-treat resistance. Clinical Infectious Diseases, 72(7), e169–e183","instname:Universidad del Rosario","reponame:Repositorio Institucional EdocUR"]},{"key":"dc:title","label":"Title","values":["Desenlaces en pacientes sépticos de una unidad de cuidado intensivo pediátrico con Programa de Optimización de Antimicrobianos (PROA). Clínica Colsubsidio Infantil 2021 - 2023","Outcomes in septic patients in a pediatric intensive care unit with an Antimicrobial Stewardship Program (ASP)"]}]}],"canonical_facts":{"dc:creator":["Romero Castro, Héctor Andrés","Cardenas Muller, Adriana"],"dc:date":["2026-01-15","2026-02-25T15:06:06Z"],"dc:description":["Se realizó un estudio observacional descriptivo de cohorte retrospectiva que incluyó 395 pacientes de 0 a 18 años con diagnóstico de sepsis manejados en la UCIP entre 2021 y 2023. Se describieron características sociodemográficas y clínicas, patrones microbiológicos, mecanismos de resistencia, decisiones antibióticas en el marco del PROA y desenlaces clínicos. Este estudio ofrece una descripción detallada de la sepsis pediátrica en una UCIP de alta complejidad en el contexto de un PROA institucional y proporciona una línea de base local sobre características clínicas, microbiológicas y desenlaces, útil para el ajuste de protocolos y para el diseño de futuras investigaciones analíticas o de implementación.","A retrospective observational cohort study was conducted including 395 patients aged 0–18 years with a diagnosis of sepsis admitted to the PICU between 2021 and 2023. Sociodemographic and clinical characteristics, microbiological patterns, resistance mechanisms, antibiotic decisions within the PROA framework and clinical outcomes were described. This study provides a detailed description of pediatric sepsis in a high-complexity PICU operating within an institutional antimicrobial stewardship program and offers a local baseline on clinical and microbiological characteristics and outcomes, which may inform protocol refinement and the design of future analytical or implementation studies."],"dc:format":["61 pp","application/pdf"],"dc:identifier":["https://doi.org/10.48713/10336_47584","https://repository.urosario.edu.co/handle/10336/47584"],"dc:language":["spa"],"dc:publisher":["Universidad del Rosario","Escuela de Medicina y Ciencias de la Salud","Especialización en Medicina Crítica y Cuidado Intensivo Pediátrico"],"dc:rights":["info:eu-repo/semantics/openAccess","http://creativecommons.org/licenses/by/4.0/"],"dc:source":["Aizawa, Y., Suwa, J., Higuchi, H., Tazumi, K., & Takeuchi, M. (2018). Antimicrobial stewardship program in a pediatric intensive care unit of a tertiary care center in Japan. Journal of the Pediatric Infectious Diseases Society, 7(3), e156–e159.","Antimicrobial Resistance Collaborators. (2023). The burden of antimicrobial resistance in the Americas in 2019: A cross-country systematic analysis. The Lancet Regional Health – Americas, 25, 100561.","Berezin, E. N., & Solórzano, F. (2014). Gram-negative infections in pediatric and neonatal intensive care units of Latin America. Journal of Infection in Developing Countries, 8(8), 942–953.","Cornistein, W., Ferrero, F., Uez, O., Speranza, N., Ardiles, R., & Ferraro, M. (2025). Prevalence and associated mortality of infections by multidrug-resistant organisms in children: A multicenter study in Latin America. Antibiotics, 14(5), 493","Fernández-Polo, A., Melendo-Pérez, S., Larrosa, N., et al. (2024). Five-year evaluation of a pediatric antimicrobial stewardship program in a tertiary-care hospital. Antibiotics, 13(6), 511","Fleischmann-Struzek, C., Goldfarb, D. M., Schlattmann, P., Schlapbach, L. J., Reinhart, K., & Kissoon, N. (2018). The global burden of paediatric and neonatal sepsis: A systematic review. The Lancet Respiratory Medicine, 6(3), 223–230.","Fonseca-Rivera, I. C., et al. (2025). Impact of an antimicrobial stewardship program on mortality and consumption of antibiotics in the intensive care units of a pediatric referral hospital in Peru. Antimicrobial Stewardship & Healthcare Epidemiology, 5(1)","Liberati, C., Brigadoi, G., et al. (2025). Antimicrobial stewardship programs in pediatric intensive care units: A systematic scoping review. Antibiotics, 14(2), 130.","Massaud-Ribeiro, L., Martinez, E. E., & Schlapbach, L. J. (2022). Pediatric sepsis research: Where are we and where are we headed? Frontiers in Pediatrics, 10, 829119.","Ministerio de Salud y Protección Social. (2017). La resistencia a los antimicrobianos: Un reto para los sistemas de salud. Ministerio de Salud y Protección Social de Colombia.","Renk, H., Regamey, N., Hitzler, M., et al. (2020). Antibiotic stewardship in the PICU: Impact of ward rounds led by pediatric infectious diseases specialists on antibiotic use. Scientific Reports, 10, 13717.","Robledo, J., Maldonado, N., Robledo, C., et al. (2022). Changes in antimicrobial resistance and etiology of blood culture isolates: Results of a decade (2010–2019) of surveillance in a northern region of Colombia. Infection and Drug Resistance, 15, 6067–6079.","Rudd, K. E., Johnson, S. C., Agesa, K. M., et al. (2020). Global, regional, and national sepsis incidence and mortality, 1990–2017: Analysis for the Global Burden of Disease Study. The Lancet, 395(10219), 200–211","Sanchez-Pinto, L. N., Schlapbach, L. J., et al. (2024). International consensus criteria for pediatric sepsis and septic shock (Phoenix criteria). JAMA, 331","Sick-Samuels, A. C., et al. (2022). Diagnostic stewardship in the pediatric intensive care unit. Current Treatment Options in Infectious Diseases, 14(1), 54–67","Watson, R. S., Carrol, E. D., Carter, M. J., et al. (2024). The burden and contemporary epidemiology of sepsis in children. The Lancet Child & Adolescent Health, 8(9), 670–681. https://doi.org/10.1016/S2352-4642(24)00135-9","Weiss, S. L., Peters, M. J., Alhazzani, W., et al. (2020). Surviving Sepsis Campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Medicine, 46(Suppl 1), 10–67","Willems, J., Hermans, E., Schelstraete, P., Depuydt, P., & De Cock, P. (2021). Optimizing the use of antibiotic agents in the pediatric intensive care unit: A narrative review. Pediatric Drugs, 23(1), 39–53.","Donà, D., Barbieri, E., Daverio, M., Lundin, R., Giaquinto, C., Zaoutis, T., & Sharland, M. (2020). Implementation and impact of pediatric antimicrobial stewardship programs: A systematic scoping review. Antimicrobial Resistance & Infection Control, 9, 3","Gaies, M. G., Gurney, J. G., Yen, A. H., et al. (2010). Vasoactive-Inotropic Score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass. Pediatric Critical Care Medicine, 11(2), 234–238","Hersh, A. L., Beekmann, S. E., Polgreen, P. M., Zaoutis, T. E., & Newland, J. G. (2013). Antimicrobial stewardship programs in pediatrics. Infectious Disease Clinics of North America, 27(1), 283–298","Newland, J. G., & Gerber, J. S. (2013). Pediatric antimicrobial stewardship programs. Infectious Disease Clinics of North America, 27(1), 91–116","Selewski, D. T., Cornell, T. T., Heung, M., Troost, J. P., Ehrmann, B. J., Lombel, R. M., Shanley, T. P., et al. (2014). Validation of the KDIGO acute kidney injury criteria in a pediatric critical care population. Intensive Care Medicine, 40(10), 1481–1488","Shah, P., et al. (2022). Using aggregate vasoactive-inotrope scores to predict outcomes in pediatric sepsis. Frontiers in Pediatrics, 10, 778378","Tamma, P. D., Aitken, S. L., Bonomo, R. A., Mathers, A. J., van Duin, D., & Clancy, C. J. (2021). IDSA guidance on the treatment of AmpC β-lactamase–producing Enterobacterales, carbapenem-resistant Enterobacterales, and Pseudomonas aeruginosa with difficult-to-treat resistance. Clinical Infectious Diseases, 72(7), e169–e183","instname:Universidad del Rosario","reponame:Repositorio Institucional EdocUR"],"dc:subject":["Sepsis","Pediatria","Cuidado intensivo pedaitrico","Programa de optimización de antimicrobianos","Resistencia bacteriana","Pediatric","Pediatric intensive care unit","Antimicrobial stewardship program","Bacterial resistance"],"dc:title":["Desenlaces en pacientes sépticos de una unidad de cuidado intensivo pediátrico con Programa de Optimización de Antimicrobianos (PROA). Clínica Colsubsidio Infantil 2021 - 2023","Outcomes in septic patients in a pediatric intensive care unit with an Antimicrobial Stewardship Program (ASP)"],"dc:type":["info:eu-repo/semantics/masterThesis","info:eu-repo/semantics/acceptedVersion"]},"updated_at":"2026-07-27T20:47:03Z"}