{"id":{"repo_id":"rosario","oai_identifier":"oai:repository.urosario.edu.co:10336/44985"},"canonical_url":"https://search.dev.ndltd.org/etd/rosario/oai:repository.urosario.edu.co:10336/44985","repository":{"repo_id":"rosario","name":"Universidad del Rosario","base_url":"https://repository.urosario.edu.co/oai/request"},"display":{"title":"Opioid Use after Transforaminal Lumbar Interbody Fusion: A Comparison between Open and Minimally Invasive Surgery","abstract":"Background: Opioids are medications frequently used in patients with moderate and severe chronic pain. Their pharmacologic profile allows their use in acute severe postoperative pain. However, due to their highly addictive profile, opioid misuse is considered a public health issue. Vertebral spine fusion, decompression, and instrumentation are often associated with acute, severe postoperative pain. The present study aims to compare postoperative opioid consumption in a group of patients who underwent open transforaminal lumbar interbody fusion (OTLIF) against a similar group of patients who underwent minimally invasive transforaminal lumbar interbody fusion (MTLIF). Methods We present a quantitative, observational, analytical, and historical cohort study. After convenience sampling, we identified 45 patients, 34 of whom underwent OTLIF and 11 underwent MTLIF. The analysis was made after measuring the following variables: demographics, type of surgery, length of stay, pain control, opioid type, and opioid dose. Statistical methods were implemented according to the origin and behavior of the variable. Results We found a difference between significant and nonsignificant pain among the groups with less opioid consumption in the MTILF group. This difference was seen in the frequency and dosage during all observation periods. However, in the postoperative observation, the frequencies and dosages were equal between groups. According to linear regression, the type of surgery, radiculopathy, and radiculitis explain the significant postoperative pain in up to 50% of cases. Conclusion Our study reveals a significant difference in opioid consumption between patients undergoing different surgical techniques. While these findings are valid for the studied population, the limitation in sample size highlights the need for further research. The implications of our findings on postoperative pain management and opioid use in spinal surgeries are significant and warrant continued investigation.","abstract_html":"Background: Opioids are medications frequently used in patients with moderate and severe chronic pain. Their pharmacologic profile allows their use in acute severe postoperative pain. However, due to their highly addictive profile, opioid misuse is considered a public health issue. Vertebral spine fusion, decompression, and instrumentation are often associated with acute, severe postoperative pain. The present study aims to compare postoperative opioid consumption in a group of patients who underwent open transforaminal lumbar interbody fusion (OTLIF) against a similar group of patients who underwent minimally invasive transforaminal lumbar interbody fusion (MTLIF). Methods We present a quantitative, observational, analytical, and historical cohort study. After convenience sampling, we identified 45 patients, 34 of whom underwent OTLIF and 11 underwent MTLIF. The analysis was made after measuring the following variables: demographics, type of surgery, length of stay, pain control, opioid type, and opioid dose. Statistical methods were implemented according to the origin and behavior of the variable. Results We found a difference between significant and nonsignificant pain among the groups with less opioid consumption in the MTILF group. This difference was seen in the frequency and dosage during all observation periods. However, in the postoperative observation, the frequencies and dosages were equal between groups. According to linear regression, the type of surgery, radiculopathy, and radiculitis explain the significant postoperative pain in up to 50% of cases. Conclusion Our study reveals a significant difference in opioid consumption between patients undergoing different surgical techniques. While these findings are valid for the studied population, the limitation in sample size highlights the need for further research. The implications of our findings on postoperative pain management and opioid use in spinal surgeries are significant and warrant continued investigation.","abstract_has_math":false,"creators":["Abaunza Camacho, Juan Felipe"],"institution":"Universidad del Rosario","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2024,"date_issued":"2024-04-03","date_published":"2024-04-03","updated_at":"2026-07-27T20:46:41Z","subjects":["Spine","Arthrodesis","Neurosurgery","Opioids","Pain management"],"languages":["spa"],"rights":["info:eu-repo/semantics/closedAccess"],"rights_urls":["http://creativecommons.org/licenses/by-nc-nd/4.0/"],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://repository.urosario.edu.co/handle/10336/44985"],"render_values":[{"text":"https://repository.urosario.edu.co/handle/10336/44985","href":"https://repository.urosario.edu.co/handle/10336/44985","code":true}]}]},"links":{"outbound_url":"https://doi.org/10.1055/s-0044-1792141","outbound_label":"DOI","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Abaunza Camacho, Juan Felipe"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2024-04-03","2025-02-17T13:57:06Z"]},{"key":"dc:publisher","label":"Institution","values":["Universidad del Rosario","Escuela de Medicina y Ciencias de la Salud","Especialización en Neurocirugía"]},{"key":"dc:type","label":"Dc Type","values":["info:eu-repo/semantics/bachelorThesis","info:eu-repo/semantics/acceptedVersion"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Spine","Arthrodesis","Neurosurgery","Opioids","Pain management"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["spa"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/closedAccess","http://creativecommons.org/licenses/by-nc-nd/4.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://doi.org/10.1055/s-0044-1792141","https://repository.urosario.edu.co/handle/10336/44985"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Background: Opioids are medications frequently used in patients with moderate and severe chronic pain. Their pharmacologic profile allows their use in acute severe postoperative pain. However, due to their highly addictive profile, opioid misuse is considered a public health issue. Vertebral spine fusion, decompression, and instrumentation are often associated with acute, severe postoperative pain. The present study aims to compare postoperative opioid consumption in a group of patients who underwent open transforaminal lumbar interbody fusion (OTLIF) against a similar group of patients who underwent minimally invasive transforaminal lumbar interbody fusion (MTLIF). Methods We present a quantitative, observational, analytical, and historical cohort study. After convenience sampling, we identified 45 patients, 34 of whom underwent OTLIF and 11 underwent MTLIF. The analysis was made after measuring the following variables: demographics, type of surgery, length of stay, pain control, opioid type, and opioid dose. Statistical methods were implemented according to the origin and behavior of the variable. Results We found a difference between significant and nonsignificant pain among the groups with less opioid consumption in the MTILF group. This difference was seen in the frequency and dosage during all observation periods. However, in the postoperative observation, the frequencies and dosages were equal between groups. According to linear regression, the type of surgery, radiculopathy, and radiculitis explain the significant postoperative pain in up to 50% of cases. Conclusion Our study reveals a significant difference in opioid consumption between patients undergoing different surgical techniques. While these findings are valid for the studied population, the limitation in sample size highlights the need for further research. The implications of our findings on postoperative pain management and opioid use in spinal surgeries are significant and warrant continued investigation."]},{"key":"dc:format","label":"Dc Format","values":["9 pp","application/pdf"]},{"key":"dc:source","label":"Dc Source","values":["BoulterJH,CurryBP,WelchMC,etal.199protocolizationofpost- transforaminallumbarinterbodyfusionpaincontrolwithelimi- nationofbenzodiazepinesandlong-actingopioids.Neurosurgery 2018;65(CN_suppl_1):115–115","GomesT,TadrousM,MamdaniMM,PatersonJM,JuurlinkDN.The burdenofopioid-relatedmortalityintheUnitedStates.JAMA NetwOpen2018;1(02):e180217","WilsonN,KariisaM,SethP,SmithHIV,DavisNL.Drugandopioid- involvedoverdosedeaths:UnitedStates,2017-2018.MMWR MorbMortalWklyRep2020;69(11):290–297","FlorenceCS,ZhouC,LuoF,XuL.Theeconomicburdenof prescriptionopioidoverdose,abuse,anddependenceinthe UnitedStates,2013.MedCare2016;54(10):901–906","OleiskyER,PenningsJS,HillsJ,etal.Comparingdifferentchronic preoperativeopioidusedefinitionsonoutcomesafterspine surgery.SpineJ2019;19(06):984–994","VolinnE,FargoJD,FinePG.Opioidtherapyfornonspecific low back painandtheoutcomeofchronicworkloss.Pain2009;142 (03):194–201","Shah A,HayesCJ,MartinBC.Characteristicsofinitialprescription episodesandlikelihoodoflong-termopioiduse:UnitedStates, 2006-2015.MMWRMorbMortalWklyRep2017;66(10): 265–269","Mendoza-EliasN,DunbarM,GhogawalaZ,WhitmoreRG.Opioid use,riskfactors,andoutcomeinlumbarfusionsurgery.World Neurosurg2020;135:e580–e587","DeyoRA,HallvikSE,HildebranC,etal.Useofprescriptionopioids beforeandafteranoperationforchronicpain(lumbarfusion surgery).Pain2018;159(06):1147–1154","CentersforDiseaseControlandPrevention(CDC)Vitalsigns: overdosesofprescriptionopioidpainrelievers:UnitedStates, 1999–2008.MMWRMorbMortalWklyRep2011;60(43): 1487–1492","Ge DH,HockleyA,Vasquez-MontesD,etal.Totalinpatient morphinemilligramequivalentscanpredictlong-termopioid useaftertransforaminallumbarinterbodyfusion.Spine2019;44 (20):1465–1470","ArmaghaniSJ,LeeDS,BibleJE,etal.Increasedpreoperative narcoticuseanditsassociationwithpostoperativecomplications andlengthofhospitalstayinpatientsundergoingspinesurgery. ClinSpineSurg2016;29(02):E93–E98","KaitoT,MatsuyamaY,YamashitaT,etal;ProjectCommitteeofthe JapaneseSocietyforSpineSurgeryandRelatedResearch(JSSR) Cost-effectivenessanalysisofthepharmacologicalmanagement of chroniclowbackpainwithfourleadingdrugs.JOrthopSci 2019;24(05):805–811","ChengJS,ParkP,LeH,ReisnerL,ChouD,MummaneniPV.Short- termandlong-termoutcomesofminimallyinvasiveandopen transforaminallumbarinterbodyfusions:isthereadifference? NeurosurgFocus2013;35(02):E6","LeeMJ,MokJ,PatelP.Transforaminallumbarinterbodyfusion: traditionalopenversusminimallyinvasivetechniques.JAmAcad OrthopSurg2018;26(04):124–131","LyDP.Evaluationandtreatmentpatternsofnewlowbackpain episodesforelderlyadultsintheUnitedStates,2011-2014.Med Care2020;58(02):108–113","KhorS,LavalleeD,CizikAM,etal.Developmentandvalidationofa predictionmodelforpainandfunctionaloutcomesafterlumbar spinesurgery.JAMASurg2018;153(07):634–642","instname:Universidad del Rosario","reponame:Repositorio Institucional EdocUR"]},{"key":"dc:title","label":"Title","values":["Opioid Use after Transforaminal Lumbar Interbody Fusion: A Comparison between Open and Minimally Invasive Surgery"]}]}],"canonical_facts":{"dc:creator":["Abaunza Camacho, Juan Felipe"],"dc:date":["2024-04-03","2025-02-17T13:57:06Z"],"dc:description":["Background: Opioids are medications frequently used in patients with moderate and severe chronic pain. Their pharmacologic profile allows their use in acute severe postoperative pain. However, due to their highly addictive profile, opioid misuse is considered a public health issue. Vertebral spine fusion, decompression, and instrumentation are often associated with acute, severe postoperative pain. The present study aims to compare postoperative opioid consumption in a group of patients who underwent open transforaminal lumbar interbody fusion (OTLIF) against a similar group of patients who underwent minimally invasive transforaminal lumbar interbody fusion (MTLIF). Methods We present a quantitative, observational, analytical, and historical cohort study. After convenience sampling, we identified 45 patients, 34 of whom underwent OTLIF and 11 underwent MTLIF. The analysis was made after measuring the following variables: demographics, type of surgery, length of stay, pain control, opioid type, and opioid dose. Statistical methods were implemented according to the origin and behavior of the variable. Results We found a difference between significant and nonsignificant pain among the groups with less opioid consumption in the MTILF group. This difference was seen in the frequency and dosage during all observation periods. However, in the postoperative observation, the frequencies and dosages were equal between groups. According to linear regression, the type of surgery, radiculopathy, and radiculitis explain the significant postoperative pain in up to 50% of cases. Conclusion Our study reveals a significant difference in opioid consumption between patients undergoing different surgical techniques. While these findings are valid for the studied population, the limitation in sample size highlights the need for further research. The implications of our findings on postoperative pain management and opioid use in spinal surgeries are significant and warrant continued investigation."],"dc:format":["9 pp","application/pdf"],"dc:identifier":["https://doi.org/10.1055/s-0044-1792141","https://repository.urosario.edu.co/handle/10336/44985"],"dc:language":["spa"],"dc:publisher":["Universidad del Rosario","Escuela de Medicina y Ciencias de la Salud","Especialización en Neurocirugía"],"dc:rights":["info:eu-repo/semantics/closedAccess","http://creativecommons.org/licenses/by-nc-nd/4.0/"],"dc:source":["BoulterJH,CurryBP,WelchMC,etal.199protocolizationofpost- transforaminallumbarinterbodyfusionpaincontrolwithelimi- nationofbenzodiazepinesandlong-actingopioids.Neurosurgery 2018;65(CN_suppl_1):115–115","GomesT,TadrousM,MamdaniMM,PatersonJM,JuurlinkDN.The burdenofopioid-relatedmortalityintheUnitedStates.JAMA NetwOpen2018;1(02):e180217","WilsonN,KariisaM,SethP,SmithHIV,DavisNL.Drugandopioid- involvedoverdosedeaths:UnitedStates,2017-2018.MMWR MorbMortalWklyRep2020;69(11):290–297","FlorenceCS,ZhouC,LuoF,XuL.Theeconomicburdenof prescriptionopioidoverdose,abuse,anddependenceinthe UnitedStates,2013.MedCare2016;54(10):901–906","OleiskyER,PenningsJS,HillsJ,etal.Comparingdifferentchronic preoperativeopioidusedefinitionsonoutcomesafterspine surgery.SpineJ2019;19(06):984–994","VolinnE,FargoJD,FinePG.Opioidtherapyfornonspecific low back painandtheoutcomeofchronicworkloss.Pain2009;142 (03):194–201","Shah A,HayesCJ,MartinBC.Characteristicsofinitialprescription episodesandlikelihoodoflong-termopioiduse:UnitedStates, 2006-2015.MMWRMorbMortalWklyRep2017;66(10): 265–269","Mendoza-EliasN,DunbarM,GhogawalaZ,WhitmoreRG.Opioid use,riskfactors,andoutcomeinlumbarfusionsurgery.World Neurosurg2020;135:e580–e587","DeyoRA,HallvikSE,HildebranC,etal.Useofprescriptionopioids beforeandafteranoperationforchronicpain(lumbarfusion surgery).Pain2018;159(06):1147–1154","CentersforDiseaseControlandPrevention(CDC)Vitalsigns: overdosesofprescriptionopioidpainrelievers:UnitedStates, 1999–2008.MMWRMorbMortalWklyRep2011;60(43): 1487–1492","Ge DH,HockleyA,Vasquez-MontesD,etal.Totalinpatient morphinemilligramequivalentscanpredictlong-termopioid useaftertransforaminallumbarinterbodyfusion.Spine2019;44 (20):1465–1470","ArmaghaniSJ,LeeDS,BibleJE,etal.Increasedpreoperative narcoticuseanditsassociationwithpostoperativecomplications andlengthofhospitalstayinpatientsundergoingspinesurgery. ClinSpineSurg2016;29(02):E93–E98","KaitoT,MatsuyamaY,YamashitaT,etal;ProjectCommitteeofthe JapaneseSocietyforSpineSurgeryandRelatedResearch(JSSR) Cost-effectivenessanalysisofthepharmacologicalmanagement of chroniclowbackpainwithfourleadingdrugs.JOrthopSci 2019;24(05):805–811","ChengJS,ParkP,LeH,ReisnerL,ChouD,MummaneniPV.Short- termandlong-termoutcomesofminimallyinvasiveandopen transforaminallumbarinterbodyfusions:isthereadifference? NeurosurgFocus2013;35(02):E6","LeeMJ,MokJ,PatelP.Transforaminallumbarinterbodyfusion: traditionalopenversusminimallyinvasivetechniques.JAmAcad OrthopSurg2018;26(04):124–131","LyDP.Evaluationandtreatmentpatternsofnewlowbackpain episodesforelderlyadultsintheUnitedStates,2011-2014.Med Care2020;58(02):108–113","KhorS,LavalleeD,CizikAM,etal.Developmentandvalidationofa predictionmodelforpainandfunctionaloutcomesafterlumbar spinesurgery.JAMASurg2018;153(07):634–642","instname:Universidad del Rosario","reponame:Repositorio Institucional EdocUR"],"dc:subject":["Spine","Arthrodesis","Neurosurgery","Opioids","Pain management"],"dc:title":["Opioid Use after Transforaminal Lumbar Interbody Fusion: A Comparison between Open and Minimally Invasive Surgery"],"dc:type":["info:eu-repo/semantics/bachelorThesis","info:eu-repo/semantics/acceptedVersion"]},"updated_at":"2026-07-27T20:46:41Z"}