Fibrolamellar Hepatocellular Carcinoma and Noncirrhotic Hyperammonemic Encephalopathy
type: CreativeWork
description: Fibrolamellar hepatocarcinoma is an infrequent liver tumor, currently considered to be a variant different from hepatocarcinoma. The differences lie in genomic alterations, a greater prevalence of fibrolamellar hepatocarcinoma in young patients, and its lack of association with underlying liver disease. The clinical presentation is unspecific, with symptoms ranging from abdominal pain, malaise, and weight loss to atypical manifestation which include hyperammonemic encephalopathy. We present the case of a 33-year-old woman with no prior medical history who presented with a coma and a diagnosis of inoperable fibrolamellar hepatocarcinoma requiring a cadaver donor transplant. While she was on the waiting list, she received hemofiltration and ammonium benzoate treatment, with progressive improvement in her state of consciousness.
abstract: Fibrolamellar hepatocarcinoma is an infrequent liver tumor, currently considered to be a variant different from hepatocarcinoma. The differences lie in genomic alterations, a greater prevalence of fibrolamellar hepatocarcinoma in young patients, and its lack of association with underlying liver disease. The clinical presentation is unspecific, with symptoms ranging from abdominal pain, malaise, and weight loss to atypical manifestation which include hyperammonemic encephalopathy. We present the case of a 33-year-old woman with no prior medical history who presented with a coma and a diagnosis of inoperable fibrolamellar hepatocarcinoma requiring a cadaver donor transplant. While she was on the waiting list, she received hemofiltration and ammonium benzoate treatment, with progressive improvement in her state of consciousness.
author: Suarez, Oscar
author: Pérez, María
author: Garzón Olarte, Martín Alonso
author: Daza, Rodrigo
author: Hernandez, Geovanny
author: Salinas, Carolina
author: Ceballos, Jorge
author: De Leon, Enrique P.
author: Mugnier, Jacqueline
author: Beltrán, Oscar
author: Varón, Adriana
language: spa
keywords: Fibrolamellar hepatocellular carcinoma, Noncirrhotic hyperammonemic encephalopathy, Enfermedades, Hepatocarcinoma fibrolamelar, Enfermedades hepáticas
license: http://creativecommons.org/licenses/by-nc-nd/2.5/co/
date published: 2018-12-03
date modified: 2026-07-27T20:46:13Z
provider: Universidad del Rosario
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Universidad del Rosario

PropertyValue
property ID: DOI
value: 10.48713/10336_18871