{"id":{"repo_id":"rosario","oai_identifier":"oai:repository.urosario.edu.co:10336/12322"},"canonical_url":"https://search.dev.ndltd.org/etd/rosario/oai:repository.urosario.edu.co:10336/12322","repository":{"repo_id":"rosario","name":"Universidad del Rosario","base_url":"https://repository.urosario.edu.co/oai/request"},"display":{"title":"Infección por virus sincitial respiratorio y su relación con valores de IGG en niños críticos","abstract":"Antecedente: La infección por el virus sincitial respiratorio (VSR) representa una elevada morbimortalidad, y en algunos casos necesidad de manejo en unidades de cuidado intensivo pediátrico (UCIP). La respuesta inmunológica influye de manera directa en la expresión de la severidad y pronóstico de los pacientes con infección respiratoria. Metodología: Estudio de una cohorte retrospectiva de pacientes con infección respiratoria grave secundaria a VSR, sin historia de inmunodeficiencia, atendidos en la UCIP del Hospital Universitario Clínica San Rafael. Se realizó análisis descriptivoglobaly de acuerdo a la categorización de las prueba de IgG. Resultados: De 188 pacientes que ingresaron a la UCIP, 13% presentaron infección por VSR (24), con una edad promedio de 7,3 (DE=3,6) meses. Pertenecían al sexo masculino79,83%. Se encontró que 12,5% tenían un valor de IgGbajo para su edad, 58,33% tenían valores en límite inferior y el 29,17% dentro de rangos normales para su edad. En los pacientes con IgG baja, fue mayor la presentación de choque séptico que no responde a líquidos (100 vs 92 vs 86%), la mediana de días de ventilación mecánica fue mayor (8 vs 6 vs 5 respectivamente), así como la mortalidad (67 vs 7,1 vs 0%). Conclusión: Nuestra serie encontró que aquellos pacientes con niveles bajos o valores en el límite inferior de IgG sérica tuvieron mayor compromiso sistémico, mayor duración de ventilación mecánica y mayor mortalidad. Se necesitan estudios prospectivos que relaciones niveles bajos de IgG con severidad y pronostico en estos pacientes con infección grave por VSR.","abstract_html":"Antecedente: La infección por el virus sincitial respiratorio (VSR) representa una elevada morbimortalidad, y en algunos casos necesidad de manejo en unidades de cuidado intensivo pediátrico (UCIP). La respuesta inmunológica influye de manera directa en la expresión de la severidad y pronóstico de los pacientes con infección respiratoria. Metodología: Estudio de una cohorte retrospectiva de pacientes con infección respiratoria grave secundaria a VSR, sin historia de inmunodeficiencia, atendidos en la UCIP del Hospital Universitario Clínica San Rafael. Se realizó análisis descriptivoglobaly de acuerdo a la categorización de las prueba de IgG. Resultados: De 188 pacientes que ingresaron a la UCIP, 13% presentaron infección por VSR (24), con una edad promedio de 7,3 (DE=3,6) meses. Pertenecían al sexo masculino79,83%. Se encontró que 12,5% tenían un valor de IgGbajo para su edad, 58,33% tenían valores en límite inferior y el 29,17% dentro de rangos normales para su edad. En los pacientes con IgG baja, fue mayor la presentación de choque séptico que no responde a líquidos (100 vs 92 vs 86%), la mediana de días de ventilación mecánica fue mayor (8 vs 6 vs 5 respectivamente), así como la mortalidad (67 vs 7,1 vs 0%). Conclusión: Nuestra serie encontró que aquellos pacientes con niveles bajos o valores en el límite inferior de IgG sérica tuvieron mayor compromiso sistémico, mayor duración de ventilación mecánica y mayor mortalidad. Se necesitan estudios prospectivos que relaciones niveles bajos de IgG con severidad y pronostico en estos pacientes con infección grave por VSR.","abstract_has_math":false,"creators":["Bonilla González, Carolina"],"institution":"Universidad del Rosario","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016-08-02","date_published":"2016-08-02","updated_at":"2026-07-27T20:47:03Z","subjects":["Virus sincitial respiratorio","inmunoglobulinas","inmunodeficiencia","hipogamaglobulineamia","unidad de cuidado intensivo pediátrico","Enfermedades","Pediatría","Cuidados críticos","Enfermedades respiratorias","Respiratory Syncytial Virus","immunoglobulins","immunodeficiency","pediatric intensive care unit"],"languages":["spa"],"rights":["info:eu-repo/semantics/openAccess"],"rights_urls":["http://creativecommons.org/licenses/by-nc-nd/2.5/co/"],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["http://repository.urosario.edu.co/handle/10336/12322"],"render_values":[{"text":"http://repository.urosario.edu.co/handle/10336/12322","href":"http://repository.urosario.edu.co/handle/10336/12322","code":true}]}]},"links":{"outbound_url":"https://doi.org/10.48713/10336_12322","outbound_label":"DOI","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Bonilla González, Carolina"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2016-08-02","2016-08-30T21:16:37Z"]},{"key":"dc:publisher","label":"Institution","values":["Universidad del Rosario","Facultad de medicina","Especialización en Cuidado Intensivo Pediátrico"]},{"key":"dc:type","label":"Dc Type","values":["info:eu-repo/semantics/masterThesis","info:eu-repo/semantics/acceptedVersion"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Virus sincitial respiratorio","inmunoglobulinas","inmunodeficiencia","hipogamaglobulineamia","unidad de cuidado intensivo pediátrico","Enfermedades","Pediatría","Cuidados críticos","Enfermedades respiratorias","Respiratory Syncytial Virus","immunoglobulins","immunodeficiency","pediatric intensive care unit"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["spa"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess","http://creativecommons.org/licenses/by-nc-nd/2.5/co/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://doi.org/10.48713/10336_12322","http://repository.urosario.edu.co/handle/10336/12322"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Antecedente: La infección por el virus sincitial respiratorio (VSR) representa una elevada morbimortalidad, y en algunos casos necesidad de manejo en unidades de cuidado intensivo pediátrico (UCIP). La respuesta inmunológica influye de manera directa en la expresión de la severidad y pronóstico de los pacientes con infección respiratoria. Metodología: Estudio de una cohorte retrospectiva de pacientes con infección respiratoria grave secundaria a VSR, sin historia de inmunodeficiencia, atendidos en la UCIP del Hospital Universitario Clínica San Rafael. Se realizó análisis descriptivoglobaly de acuerdo a la categorización de las prueba de IgG. Resultados: De 188 pacientes que ingresaron a la UCIP, 13% presentaron infección por VSR (24), con una edad promedio de 7,3 (DE=3,6) meses. Pertenecían al sexo masculino79,83%. Se encontró que 12,5% tenían un valor de IgGbajo para su edad, 58,33% tenían valores en límite inferior y el 29,17% dentro de rangos normales para su edad. En los pacientes con IgG baja, fue mayor la presentación de choque séptico que no responde a líquidos (100 vs 92 vs 86%), la mediana de días de ventilación mecánica fue mayor (8 vs 6 vs 5 respectivamente), así como la mortalidad (67 vs 7,1 vs 0%). Conclusión: Nuestra serie encontró que aquellos pacientes con niveles bajos o valores en el límite inferior de IgG sérica tuvieron mayor compromiso sistémico, mayor duración de ventilación mecánica y mayor mortalidad. Se necesitan estudios prospectivos que relaciones niveles bajos de IgG con severidad y pronostico en estos pacientes con infección grave por VSR.","Background: Respiratory Syncytial Virus (RSV) infection represents a high morbidity and mortality, and in some cases management in pediatric intensive care units (PICU). The immune response directly influences the severity and prognosis of patients with respiratory infection. Methodology: A retrospective study of a cohort of patients with severe RSV respiratory infection and no history of immunodeficiency was conducted in the PICU of San Rafael University Hospital Clinic. Global descriptive analysis was performed and according to the categorization of IgG tests analysis. Results: Of 188 patients admitted to the PICU, 13% had RSV infection (24), with an average age of 7. 3 (SD = 3. 6) months; 79. 83% were male. Twelve point five percent had a low value of IgG, 58. 33% had a lower limit value and 29. 17% within the normal range for their age. In patients with low IgG was higher septic shock unresponsive to liquids (100 vs 92 vs 86%), median days of mechanical ventilation (8 vs 6 vs 5, respectively) and mortality (67 vs 7. 1 vs 0%). Conclusion: Our series found that patients with low levels or lower limit values of IgG had more systemic involvement, longer duration of mechanical ventilation and increased mortality. Prospective studies are needed that low levels of IgG relationships with severity and prognosis for these patients with severe RSV infection."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:source","label":"Dc Source","values":["1. Secretaría Distrital de Salud de Bogotá. Boletin II trimestre de 2014. Boletin enfermedad respiratoria aguda ERA [Internet]. 2014. [CItado 5 de julio de 2016]. Disponible en:http://www.saludcapital.gov.co/DSP/ERA/Bolet%C3%ADn%20ERA%20II%20Trimest re%202014.pdf","2. Casto J RD. Caracterizaciòn del Virus Sincitial Respiratorio en la Unidad de Cuidados Intensivos Pediàtricos del Hospital Universitario Clìnica San Rafael de Bogotà en el Periodo de enero 1 a junio 30 de los años 2010 y 2011: Universidad Militar Nueva Granada 2012.","3. K. M. Developments in respiratory syncytial virus (RSV) I: pathogenesis. Medwave. 2008;8(9):1713.","4. Walsh EE, Peterson DR, Falsey AR. Risk factors for severe respiratory syncytial virus infection in elderly persons. J Infect Dis. 2004;189(2):233-8.","5. Fields BN, Knipe DM, Howley PM. Paramyxoviridae: Respiratory Syncytial Virus and Metapneumovirus. Fields' Virology. II: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2007. p. 3177.","6. Johnson PR, Spriggs MK, Olmsted RA, Collins PL. The G glycoprotein of human respiratory syncytial viruses of subgroups A and B: extensive sequence divergence between antigenically related proteins. Proc Natl Acad Sci U S A. 1987;84(16):5625-9.","7. Murphy BR. WR. Orthomyxoviruses. In: Knippe DM HP, editor. Fields BN. 3 ed. Nueva York: Lippincot-Raven 1996. p. 1397.","8. Eiros JM, Ortiz de Lejarazu R, Tenorio A, Casas I, Pozo F, Ruiz G, et al. [Microbiological diagnosis of viral respiratory infections]. Enferm Infecc Microbiol Clin. 2009;27(3):168-77.","9. Yamaguchi M, Sano Y, Dapat IC, Saito R, Suzuki Y, Kumaki A, et al. 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Virus Respiratorios en Menores de Diez Años con Infección Respiratoria en el Hospital Militar Central de Bogotá. Revista de Salud Pública. 2007;9(4):576-86.","70. Welliver Sr RC. Temperature, humidity, and ultraviolet B radiation predict community respiratory syncytial virus activity. The Pediatric infectious disease journal. 2007;26(11):S29-S35.","71. Secretaría Distrital de Salud de Bogotá. Boletín informativo distrital de impactos en la salud de los eventos climáticos extremos asociados a variabilidad climática. Bogotá, Colombia. [Internet]. 2015. [Citado 30 de junio de 2015]; 66:1-11 . Disponible en:http://biblioteca.saludcapital.gov.co/img_upload/57c59a889ca266ee6533c26f970cb14a/ Boletin Abr_15.pdf.","72. Arruvito L, Raiden S, Geffner J. Host response to respiratory syncytial virus infection. Current opinion in infectious diseases. 2015;28(3):259-66.","73. Lacroix-Desmazes S, Bayry J, Kaveri SV, Hayon-Sonsino D, Thorenoor N, Charpentier J, et al. High levels of catalytic antibodies correlate with favorable outcome in sepsis. Proceedings of the National Academy of Sciences of the United States of America. 2005;102(11):4109-13.","74. Bermejo‐Martín JF, Rodriguez‐Fernandez A, Herrán‐Monge R, Andaluz‐Ojeda D, Muriel‐Bombín A, Merino P, et al. Immunoglobulins IgG1, IgM and IgA: a synergistic team influencing survival in sepsis. Journal of internal medicine. 2014;276(4):404-12.","75. Andaluz-Ojeda D, Iglesias V, Bobillo F, Almansa R, Rico L, Gandía F, et al. Early natural killer cell counts in blood predict mortality in severe sepsis. Crit Care. 2011;15(5):R243.","76. Tamayo E, Fernández A, Almansa R, Carrasco E, Goncalves L, Heredia M, et al. Beneficial role of endogenous immunoglobulin subclasses and isotypes in septic shock. Journal of critical care. 2012;27(6):616-22.","77. Taccone FS, Stordeur P, De Backer D, Creteur J, Vincent J-L. γ-globulin levels in patients with community-acquired septic shock. Shock. 2009;32(4):379-85.","78. Venet F, Gebeile R, Bancel J, Guignant C, Poitevin-Later F, Malcus C, et al. Assessment of plasmatic immunoglobulin G, A and M levels in septic shock patients. International immunopharmacology. 2011;11(12):2086-90.","instname:Universidad del Rosario","reponame:Repositorio Institucional EdocUR"]},{"key":"dc:title","label":"Title","values":["Infección por virus sincitial respiratorio y su relación con valores de IGG en niños críticos"]}]}],"canonical_facts":{"dc:creator":["Bonilla González, Carolina"],"dc:date":["2016-08-02","2016-08-30T21:16:37Z"],"dc:description":["Antecedente: La infección por el virus sincitial respiratorio (VSR) representa una elevada morbimortalidad, y en algunos casos necesidad de manejo en unidades de cuidado intensivo pediátrico (UCIP). La respuesta inmunológica influye de manera directa en la expresión de la severidad y pronóstico de los pacientes con infección respiratoria. Metodología: Estudio de una cohorte retrospectiva de pacientes con infección respiratoria grave secundaria a VSR, sin historia de inmunodeficiencia, atendidos en la UCIP del Hospital Universitario Clínica San Rafael. Se realizó análisis descriptivoglobaly de acuerdo a la categorización de las prueba de IgG. Resultados: De 188 pacientes que ingresaron a la UCIP, 13% presentaron infección por VSR (24), con una edad promedio de 7,3 (DE=3,6) meses. Pertenecían al sexo masculino79,83%. Se encontró que 12,5% tenían un valor de IgGbajo para su edad, 58,33% tenían valores en límite inferior y el 29,17% dentro de rangos normales para su edad. En los pacientes con IgG baja, fue mayor la presentación de choque séptico que no responde a líquidos (100 vs 92 vs 86%), la mediana de días de ventilación mecánica fue mayor (8 vs 6 vs 5 respectivamente), así como la mortalidad (67 vs 7,1 vs 0%). Conclusión: Nuestra serie encontró que aquellos pacientes con niveles bajos o valores en el límite inferior de IgG sérica tuvieron mayor compromiso sistémico, mayor duración de ventilación mecánica y mayor mortalidad. Se necesitan estudios prospectivos que relaciones niveles bajos de IgG con severidad y pronostico en estos pacientes con infección grave por VSR.","Background: Respiratory Syncytial Virus (RSV) infection represents a high morbidity and mortality, and in some cases management in pediatric intensive care units (PICU). The immune response directly influences the severity and prognosis of patients with respiratory infection. Methodology: A retrospective study of a cohort of patients with severe RSV respiratory infection and no history of immunodeficiency was conducted in the PICU of San Rafael University Hospital Clinic. Global descriptive analysis was performed and according to the categorization of IgG tests analysis. Results: Of 188 patients admitted to the PICU, 13% had RSV infection (24), with an average age of 7. 3 (SD = 3. 6) months; 79. 83% were male. Twelve point five percent had a low value of IgG, 58. 33% had a lower limit value and 29. 17% within the normal range for their age. In patients with low IgG was higher septic shock unresponsive to liquids (100 vs 92 vs 86%), median days of mechanical ventilation (8 vs 6 vs 5, respectively) and mortality (67 vs 7. 1 vs 0%). Conclusion: Our series found that patients with low levels or lower limit values of IgG had more systemic involvement, longer duration of mechanical ventilation and increased mortality. Prospective studies are needed that low levels of IgG relationships with severity and prognosis for these patients with severe RSV infection."],"dc:format":["application/pdf"],"dc:identifier":["https://doi.org/10.48713/10336_12322","http://repository.urosario.edu.co/handle/10336/12322"],"dc:language":["spa"],"dc:publisher":["Universidad del Rosario","Facultad de medicina","Especialización en Cuidado Intensivo Pediátrico"],"dc:rights":["info:eu-repo/semantics/openAccess","http://creativecommons.org/licenses/by-nc-nd/2.5/co/"],"dc:source":["1. Secretaría Distrital de Salud de Bogotá. Boletin II trimestre de 2014. Boletin enfermedad respiratoria aguda ERA [Internet]. 2014. [CItado 5 de julio de 2016]. Disponible en:http://www.saludcapital.gov.co/DSP/ERA/Bolet%C3%ADn%20ERA%20II%20Trimest re%202014.pdf","2. Casto J RD. 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International immunopharmacology. 2011;11(12):2086-90.","instname:Universidad del Rosario","reponame:Repositorio Institucional EdocUR"],"dc:subject":["Virus sincitial respiratorio","inmunoglobulinas","inmunodeficiencia","hipogamaglobulineamia","unidad de cuidado intensivo pediátrico","Enfermedades","Pediatría","Cuidados críticos","Enfermedades respiratorias","Respiratory Syncytial Virus","immunoglobulins","immunodeficiency","pediatric intensive care unit"],"dc:title":["Infección por virus sincitial respiratorio y su relación con valores de IGG en niños críticos"],"dc:type":["info:eu-repo/semantics/masterThesis","info:eu-repo/semantics/acceptedVersion"]},"updated_at":"2026-07-27T20:47:03Z"}