The specificity of the immune response to antigen was first appreciated by the study of serum immunoglobulins (Igs). The subpopulation of lymphoid cells that synthesize these molecules are so defined as members of the B lineage; the end-stage cell type of this lineage is the plasma cell. The acceptance, over the past thirty years, of myeloma proteins as normal products of plasma cells in clonal overgrowth (Kunkel, 1966) has provided both a homogeneous source for study and a paradigm. The structural characteristics of Igs which form the basis of specificity can now be, literally, seen in three dimensions; it is likely that all other antigen-reactive molecules, of different cell types in the system, will share similar structural characteristics.
","abstract_html":"<p>The specificity of the immune response to antigen was first appreciated by the study of serum immunoglobulins (Igs). The subpopulation of lymphoid cells that synthesize these molecules are so defined as members of the B lineage; the end-stage cell type of this lineage is the plasma cell. The acceptance, over the past thirty years, of myeloma proteins as normal products of plasma cells in clonal overgrowth (Kunkel, 1966) has provided both a homogeneous source for study and a paradigm. The structural characteristics of Igs which form the basis of specificity can now be, literally, seen in three dimensions; it is likely that all other antigen-reactive molecules, of different cell types in the system, will share similar structural characteristics.</p>","abstract_has_math":false,"creators":["McCune, Joseph M"],"institution":null,"degree_name":"Doctor of Philosophy (PhD)","degree_level":"Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":["Henry Kunkel"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1981,"date_issued":"1981-01-01T08:00:00Z","date_published":"1981-01-01T08:00:00Z","updated_at":"2026-07-24T04:11:45Z","subjects":["immunoglobulins","B lineage","plasma cells","myeloma","antigen specificity","protein structure","Life Sciences"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.rockefeller.edu/student_theses_and_dissertations/745","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Henry Kunkel"]},{"key":"dc:creator","label":"Author","values":["McCune, Joseph M"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (PhD)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["immunoglobulins","B lineage","plasma cells","myeloma","antigen specificity","protein structure","Life Sciences"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://digitalcommons.rockefeller.edu/student_theses_and_dissertations/745"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The specificity of the immune response to antigen was first appreciated by the study of serum immunoglobulins (Igs). The subpopulation of lymphoid cells that synthesize these molecules are so defined as members of the B lineage; the end-stage cell type of this lineage is the plasma cell. The acceptance, over the past thirty years, of myeloma proteins as normal products of plasma cells in clonal overgrowth (Kunkel, 1966) has provided both a homogeneous source for study and a paradigm. The structural characteristics of Igs which form the basis of specificity can now be, literally, seen in three dimensions; it is likely that all other antigen-reactive molecules, of different cell types in the system, will share similar structural characteristics.
"]},{"key":"dc:title","label":"Title","values":["Biogenesis of Membrane-Bound and Secreted Immunoglobulins"]}]}],"canonical_facts":{"dc:contributor":["Henry Kunkel"],"dc:creator":["McCune, Joseph M"],"dc:description.abstract":["The specificity of the immune response to antigen was first appreciated by the study of serum immunoglobulins (Igs). The subpopulation of lymphoid cells that synthesize these molecules are so defined as members of the B lineage; the end-stage cell type of this lineage is the plasma cell. The acceptance, over the past thirty years, of myeloma proteins as normal products of plasma cells in clonal overgrowth (Kunkel, 1966) has provided both a homogeneous source for study and a paradigm. The structural characteristics of Igs which form the basis of specificity can now be, literally, seen in three dimensions; it is likely that all other antigen-reactive molecules, of different cell types in the system, will share similar structural characteristics.
"],"dc:identifier":["https://digitalcommons.rockefeller.edu/student_theses_and_dissertations/745"],"dc:subject":["immunoglobulins","B lineage","plasma cells","myeloma","antigen specificity","protein structure","Life Sciences"],"dc:title":["Biogenesis of Membrane-Bound and Secreted Immunoglobulins"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Doctor of Philosophy (PhD)"]},"updated_at":"2026-07-24T04:11:45Z"}