Eukaryotic cells replicate their DNA during a defined time period in the interphase between mitoses. Non-proliferating cells are generally found to be blocked in interphase prior to the DNA-synthetic period. It therefore appears that the control of cellular proliferation may be intimately related to regulation of DNA synthesis. Defining the mechanism for the regulation of DNA replication is a central problem in the biology of higher animal cells. The introductory section of this thesis attempts to bring together the currently available evidence into a coherent model for in vivo regulated DNA replication. Animal viruses can be used as tools to study cellular DNA replication. Certain RNA viruses which multiply in the cytoplasm of host cells inhibit cellular DNA synthesis. The work described in this thesis represents an effort to locate the step in cellular DNA synthesis which is primarily affected in consequence of the multiplication of three cytoplasmic RNA viruses, mengovirus, Newcastle disease virus, and reovirus type 3. The general method of analysis used and the results obtained are discussed within the framework of the model presented in the Introduction.
","abstract_html":"<p>Eukaryotic cells replicate their DNA during a defined time period in the interphase between mitoses. Non-proliferating cells are generally found to be blocked in interphase prior to the DNA-synthetic period. It therefore appears that the control of cellular proliferation may be intimately related to regulation of DNA synthesis. Defining the mechanism for the regulation of DNA replication is a central problem in the biology of higher animal cells. The introductory section of this thesis attempts to bring together the currently available evidence into a coherent model for in vivo regulated DNA replication. Animal viruses can be used as tools to study cellular DNA replication. Certain RNA viruses which multiply in the cytoplasm of host cells inhibit cellular DNA synthesis. The work described in this thesis represents an effort to locate the step in cellular DNA synthesis which is primarily affected in consequence of the multiplication of three cytoplasmic RNA viruses, mengovirus, Newcastle disease virus, and reovirus type 3. The general method of analysis used and the results obtained are discussed within the framework of the model presented in the Introduction.</p>","abstract_has_math":false,"creators":["Ensminger, William D"],"institution":null,"degree_name":"Doctor of Philosophy (PhD)","degree_level":"Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":["Igor Tamm"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1969,"date_issued":"1969-01-01T08:00:00Z","date_published":"1969-01-01T08:00:00Z","updated_at":"2026-07-24T04:11:21Z","subjects":["DNA replication","cell cycle","RNA viruses","mengovirus","cellular proliferation","viral inhibition","Life Sciences"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.rockefeller.edu/student_theses_and_dissertations/603","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Igor Tamm"]},{"key":"dc:creator","label":"Author","values":["Ensminger, William D"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (PhD)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["DNA replication","cell cycle","RNA viruses","mengovirus","cellular proliferation","viral inhibition","Life Sciences"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://digitalcommons.rockefeller.edu/student_theses_and_dissertations/603"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Eukaryotic cells replicate their DNA during a defined time period in the interphase between mitoses. Non-proliferating cells are generally found to be blocked in interphase prior to the DNA-synthetic period. It therefore appears that the control of cellular proliferation may be intimately related to regulation of DNA synthesis. Defining the mechanism for the regulation of DNA replication is a central problem in the biology of higher animal cells. The introductory section of this thesis attempts to bring together the currently available evidence into a coherent model for in vivo regulated DNA replication. Animal viruses can be used as tools to study cellular DNA replication. Certain RNA viruses which multiply in the cytoplasm of host cells inhibit cellular DNA synthesis. The work described in this thesis represents an effort to locate the step in cellular DNA synthesis which is primarily affected in consequence of the multiplication of three cytoplasmic RNA viruses, mengovirus, Newcastle disease virus, and reovirus type 3. The general method of analysis used and the results obtained are discussed within the framework of the model presented in the Introduction.
"]},{"key":"dc:title","label":"Title","values":["Viral Inhibition of Mammalian Cell DNA Synthesis"]}]}],"canonical_facts":{"dc:contributor":["Igor Tamm"],"dc:creator":["Ensminger, William D"],"dc:description.abstract":["Eukaryotic cells replicate their DNA during a defined time period in the interphase between mitoses. Non-proliferating cells are generally found to be blocked in interphase prior to the DNA-synthetic period. It therefore appears that the control of cellular proliferation may be intimately related to regulation of DNA synthesis. Defining the mechanism for the regulation of DNA replication is a central problem in the biology of higher animal cells. The introductory section of this thesis attempts to bring together the currently available evidence into a coherent model for in vivo regulated DNA replication. Animal viruses can be used as tools to study cellular DNA replication. Certain RNA viruses which multiply in the cytoplasm of host cells inhibit cellular DNA synthesis. The work described in this thesis represents an effort to locate the step in cellular DNA synthesis which is primarily affected in consequence of the multiplication of three cytoplasmic RNA viruses, mengovirus, Newcastle disease virus, and reovirus type 3. The general method of analysis used and the results obtained are discussed within the framework of the model presented in the Introduction.
"],"dc:identifier":["https://digitalcommons.rockefeller.edu/student_theses_and_dissertations/603"],"dc:subject":["DNA replication","cell cycle","RNA viruses","mengovirus","cellular proliferation","viral inhibition","Life Sciences"],"dc:title":["Viral Inhibition of Mammalian Cell DNA Synthesis"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Doctor of Philosophy (PhD)"]},"updated_at":"2026-07-24T04:11:21Z"}