The initial observation that delayed-type hypersensitivity could be transferred from an allergic to a normal animal by means of living white cells was made at The Rockefeller Institute many years ago. Since that time it has been recognized that cellular transfer appears to be a unifying principle underlying both contact dermatitis and tuberculin hypersensitivity. Later studies in man have suggested that the phenomenon can be reproduced with use cell-free extracts. Similar attempts have been made with extracts of cells from sensitized guinea pigs but, there exist only three reports in the literature which claim that transfer of contact or tuberculin hypersensitivity can be readily accomplished between animals (guinea pigs) by means of disrupted cells or subcellular materials.
","abstract_html":"<p>The initial observation that delayed-type hypersensitivity could be transferred from an allergic to a normal animal by means of living white cells was made at The Rockefeller Institute many years ago. Since that time it has been recognized that cellular transfer appears to be a unifying principle underlying both contact dermatitis and tuberculin hypersensitivity. Later studies in man have suggested that the phenomenon can be reproduced with use cell-free extracts. Similar attempts have been made with extracts of cells from sensitized guinea pigs but, there exist only three reports in the literature which claim that transfer of contact or tuberculin hypersensitivity can be readily accomplished between animals (guinea pigs) by means of disrupted cells or subcellular materials.</p>","abstract_has_math":false,"creators":["Bloom, Barry R"],"institution":null,"degree_name":"Doctor of Philosophy (PhD)","degree_level":"Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":["Merrill Chase"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1963,"date_issued":"1963-01-01T08:00:00Z","date_published":"1963-01-01T08:00:00Z","updated_at":"2026-07-24T04:10:53Z","subjects":["delayed hypersensitivity","cellular transfer","contact dermatitis","tuberculin hypersensitivity","white cells","sensitized guinea pigs","Life Sciences"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.rockefeller.edu/student_theses_and_dissertations/570","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Merrill Chase"]},{"key":"dc:creator","label":"Author","values":["Bloom, Barry R"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (PhD)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["delayed hypersensitivity","cellular transfer","contact dermatitis","tuberculin hypersensitivity","white cells","sensitized guinea pigs","Life Sciences"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://digitalcommons.rockefeller.edu/student_theses_and_dissertations/570"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The initial observation that delayed-type hypersensitivity could be transferred from an allergic to a normal animal by means of living white cells was made at The Rockefeller Institute many years ago. Since that time it has been recognized that cellular transfer appears to be a unifying principle underlying both contact dermatitis and tuberculin hypersensitivity. Later studies in man have suggested that the phenomenon can be reproduced with use cell-free extracts. Similar attempts have been made with extracts of cells from sensitized guinea pigs but, there exist only three reports in the literature which claim that transfer of contact or tuberculin hypersensitivity can be readily accomplished between animals (guinea pigs) by means of disrupted cells or subcellular materials.
"]},{"key":"dc:title","label":"Title","values":["Studies on Delayed-Type Hypersensitivity Including Attempts to Effect Transfer in Guinea Pigs with Subcellular Materials"]}]}],"canonical_facts":{"dc:contributor":["Merrill Chase"],"dc:creator":["Bloom, Barry R"],"dc:description.abstract":["The initial observation that delayed-type hypersensitivity could be transferred from an allergic to a normal animal by means of living white cells was made at The Rockefeller Institute many years ago. Since that time it has been recognized that cellular transfer appears to be a unifying principle underlying both contact dermatitis and tuberculin hypersensitivity. Later studies in man have suggested that the phenomenon can be reproduced with use cell-free extracts. Similar attempts have been made with extracts of cells from sensitized guinea pigs but, there exist only three reports in the literature which claim that transfer of contact or tuberculin hypersensitivity can be readily accomplished between animals (guinea pigs) by means of disrupted cells or subcellular materials.
"],"dc:identifier":["https://digitalcommons.rockefeller.edu/student_theses_and_dissertations/570"],"dc:subject":["delayed hypersensitivity","cellular transfer","contact dermatitis","tuberculin hypersensitivity","white cells","sensitized guinea pigs","Life Sciences"],"dc:title":["Studies on Delayed-Type Hypersensitivity Including Attempts to Effect Transfer in Guinea Pigs with Subcellular Materials"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Doctor of Philosophy (PhD)"]},"updated_at":"2026-07-24T04:10:53Z"}