Since the discovery (Tan and Kunkel, 1966; Mattioli and Peichlin, 1971; Sharp, et al., 1972) of human SLE autoantibodies directed against RNA-protein complexes in eucaryotic nuclei, a great deal of interest has been generated regarding both the relationships of antibody specificities to disease and the biological roles of the recognized antigens. These antibodies are some of the many autoantibody species which have been described in systemic lupus erythematosus (SLE) as well as other rheimatic disease conditions. A common feature of many of these reactivities is the apparent nuclear localization of antigen. Study of the antibodies as well as these antigens has led to formation of a particularly unique bridge between clinical medicine and basic science questions in cellular biology and metabolism. The spectrum of diseases which present with antibodies directed against cellular constituents is vast although certain features of these conditions imply common aspects which may, furthermore, be of some diagnostic use.
","abstract_html":"<p>Since the discovery (Tan and Kunkel, 1966; Mattioli and Peichlin, 1971; Sharp, et al., 1972) of human SLE autoantibodies directed against RNA-protein complexes in eucaryotic nuclei, a great deal of interest has been generated regarding both the relationships of antibody specificities to disease and the biological roles of the recognized antigens. These antibodies are some of the many autoantibody species which have been described in systemic lupus erythematosus (SLE) as well as other rheimatic disease conditions. A common feature of many of these reactivities is the apparent nuclear localization of antigen. Study of the antibodies as well as these antigens has led to formation of a particularly unique bridge between clinical medicine and basic science questions in cellular biology and metabolism. The spectrum of diseases which present with antibodies directed against cellular constituents is vast although certain features of these conditions imply common aspects which may, furthermore, be of some diagnostic use.</p>","abstract_has_math":false,"creators":["Fisher, David E"],"institution":null,"degree_name":"Doctor of Philosophy (PhD)","degree_level":"Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":["Henry Kunkel"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1984,"date_issued":"1984-01-01T08:00:00Z","date_published":"1984-01-01T08:00:00Z","updated_at":"2026-07-24T04:10:53Z","subjects":["SLE autoantibodies","RNA-protein complexes","systemic lupus erythematosus","autoantigens","nuclear localization","rheumatic diseases","Life Sciences"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.rockefeller.edu/student_theses_and_dissertations/465","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Henry Kunkel"]},{"key":"dc:creator","label":"Author","values":["Fisher, David E"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (PhD)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["SLE autoantibodies","RNA-protein complexes","systemic lupus erythematosus","autoantigens","nuclear localization","rheumatic diseases","Life Sciences"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://digitalcommons.rockefeller.edu/student_theses_and_dissertations/465"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Since the discovery (Tan and Kunkel, 1966; Mattioli and Peichlin, 1971; Sharp, et al., 1972) of human SLE autoantibodies directed against RNA-protein complexes in eucaryotic nuclei, a great deal of interest has been generated regarding both the relationships of antibody specificities to disease and the biological roles of the recognized antigens. These antibodies are some of the many autoantibody species which have been described in systemic lupus erythematosus (SLE) as well as other rheimatic disease conditions. A common feature of many of these reactivities is the apparent nuclear localization of antigen. Study of the antibodies as well as these antigens has led to formation of a particularly unique bridge between clinical medicine and basic science questions in cellular biology and metabolism. The spectrum of diseases which present with antibodies directed against cellular constituents is vast although certain features of these conditions imply common aspects which may, furthermore, be of some diagnostic use.
"]},{"key":"dc:title","label":"Title","values":["Distinct Examples of Immunologic Analysis in Molecular and Cellular Biology: Small Nuclear Ribonucleoproteins and the T Cell Receptor"]}]}],"canonical_facts":{"dc:contributor":["Henry Kunkel"],"dc:creator":["Fisher, David E"],"dc:description.abstract":["Since the discovery (Tan and Kunkel, 1966; Mattioli and Peichlin, 1971; Sharp, et al., 1972) of human SLE autoantibodies directed against RNA-protein complexes in eucaryotic nuclei, a great deal of interest has been generated regarding both the relationships of antibody specificities to disease and the biological roles of the recognized antigens. These antibodies are some of the many autoantibody species which have been described in systemic lupus erythematosus (SLE) as well as other rheimatic disease conditions. A common feature of many of these reactivities is the apparent nuclear localization of antigen. Study of the antibodies as well as these antigens has led to formation of a particularly unique bridge between clinical medicine and basic science questions in cellular biology and metabolism. The spectrum of diseases which present with antibodies directed against cellular constituents is vast although certain features of these conditions imply common aspects which may, furthermore, be of some diagnostic use.
"],"dc:identifier":["https://digitalcommons.rockefeller.edu/student_theses_and_dissertations/465"],"dc:subject":["SLE autoantibodies","RNA-protein complexes","systemic lupus erythematosus","autoantigens","nuclear localization","rheumatic diseases","Life Sciences"],"dc:title":["Distinct Examples of Immunologic Analysis in Molecular and Cellular Biology: Small Nuclear Ribonucleoproteins and the T Cell Receptor"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Doctor of Philosophy (PhD)"]},"updated_at":"2026-07-24T04:10:53Z"}