{"id":{"repo_id":"rice","oai_identifier":"oai:repository.rice.edu:1911/77586"},"canonical_url":"https://search.dev.ndltd.org/etd/rice/oai:repository.rice.edu:1911/77586","repository":{"repo_id":"rice","name":"Rice University","base_url":"https://repository.rice.edu/server/oai/request"},"display":{"title":"A Novel Statistical Potential for Protein Beta-Sheets Prediction","abstract":"One of the most long-term challenging problems in biophysics studies for both computational scientists and experimentalists is protein structure prediction, whose goal is to obtain three-dimensional native protein structure from one-dimensional sequence. In protein structure prediction problems, a fundamental problem is Beta-sheets structure prediction. Though more than 85% of experimentally solved proteins contain Beta-sheet structures, limited methods have been found to rapidly and accurately predict the folded conformations. In this study, we proposed a novel statistical potential, named NP-Beta, to predict the protein Beta-sheet structure only based on the sequence information. We included three kinds of potential terms in NP-Beta, i.e. the self-packing term, the pair interacting term and the lattice term. The number of hydrogen bonds in Beta-sheets is also considered as a potential component, corresponding to a global penalty of the potential function. Computational tests show that the new statistical potential has an outstanding performance on native structure recognition from decoys comparing to the Beta-sheet specific potentials in literature. We will apply the potential to improve the prediction of Beta-strand arrangement and registration for beta proteins.","abstract_html":"One of the most long-term challenging problems in biophysics studies for both computational scientists and experimentalists is protein structure prediction, whose goal is to obtain three-dimensional native protein structure from one-dimensional sequence. In protein structure prediction problems, a fundamental problem is Beta-sheets structure prediction. Though more than 85% of experimentally solved proteins contain Beta-sheet structures, limited methods have been found to rapidly and accurately predict the folded conformations. In this study, we proposed a novel statistical potential, named NP-Beta, to predict the protein Beta-sheet structure only based on the sequence information. We included three kinds of potential terms in NP-Beta, i.e. the self-packing term, the pair interacting term and the lattice term. The number of hydrogen bonds in Beta-sheets is also considered as a potential component, corresponding to a global penalty of the potential function. Computational tests show that the new statistical potential has an outstanding performance on native structure recognition from decoys comparing to the Beta-sheet specific potentials in literature. We will apply the potential to improve the prediction of Beta-strand arrangement and registration for beta proteins.","abstract_has_math":false,"creators":["Yu, Linglin"],"institution":"Rice University","degree_name":"Master of Science","degree_level":"Masters","degree_discipline":"Natural Sciences","degree_department":null,"school":null,"contributors":[],"advisors":["Ma, Jianpeng"],"committee_chairs":[],"committee_members":["Nordlander, Peter J.","Raphael, Robert M."],"year":2014,"date_issued":"2014-04-25","date_published":"2014-04-25","updated_at":"2026-07-24T04:10:28Z","subjects":["Statistical potential","Beta-Sheets"],"languages":["eng"],"rights":["Copyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/1911/77586","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Ma, Jianpeng"]},{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Nordlander, Peter J.","Raphael, Robert M."]},{"key":"dc:creator","label":"Author","values":["Yu, Linglin"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-10-16T18:08:35Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-10-16T18:08:35Z"]},{"key":"dc:date.issued","label":"Date","values":["2014-04-25"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Natural Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Rice University"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Statistical potential","Beta-Sheets"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/1911/77586"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["One of the most long-term challenging problems in biophysics studies for both computational scientists and experimentalists is protein structure prediction, whose goal is to obtain three-dimensional native protein structure from one-dimensional sequence. In protein structure prediction problems, a fundamental problem is Beta-sheets structure prediction. Though more than 85% of experimentally solved proteins contain Beta-sheet structures, limited methods have been found to rapidly and accurately predict the folded conformations. In this study, we proposed a novel statistical potential, named NP-Beta, to predict the protein Beta-sheet structure only based on the sequence information. We included three kinds of potential terms in NP-Beta, i.e. the self-packing term, the pair interacting term and the lattice term. The number of hydrogen bonds in Beta-sheets is also considered as a potential component, corresponding to a global penalty of the potential function. Computational tests show that the new statistical potential has an outstanding performance on native structure recognition from decoys comparing to the Beta-sheet specific potentials in literature. We will apply the potential to improve the prediction of Beta-strand arrangement and registration for beta proteins."]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["A Novel Statistical Potential for Protein Beta-Sheets Prediction"]}]}],"canonical_facts":{"dc:contributor.advisor":["Ma, Jianpeng"],"dc:contributor.committeemember":["Nordlander, Peter J.","Raphael, Robert M."],"dc:creator":["Yu, Linglin"],"dc:date.accessioned":["2014-10-16T18:08:35Z"],"dc:date.available":["2014-10-16T18:08:35Z"],"dc:date.issued":["2014-04-25"],"dc:description.abstract":["One of the most long-term challenging problems in biophysics studies for both computational scientists and experimentalists is protein structure prediction, whose goal is to obtain three-dimensional native protein structure from one-dimensional sequence. In protein structure prediction problems, a fundamental problem is Beta-sheets structure prediction. Though more than 85% of experimentally solved proteins contain Beta-sheet structures, limited methods have been found to rapidly and accurately predict the folded conformations. In this study, we proposed a novel statistical potential, named NP-Beta, to predict the protein Beta-sheet structure only based on the sequence information. We included three kinds of potential terms in NP-Beta, i.e. the self-packing term, the pair interacting term and the lattice term. The number of hydrogen bonds in Beta-sheets is also considered as a potential component, corresponding to a global penalty of the potential function. Computational tests show that the new statistical potential has an outstanding performance on native structure recognition from decoys comparing to the Beta-sheet specific potentials in literature. We will apply the potential to improve the prediction of Beta-strand arrangement and registration for beta proteins."],"dc:format.mimetype":["application/pdf"],"dc:identifier.uri":["https://hdl.handle.net/1911/77586"],"dc:language.iso":["eng"],"dc:rights":["Copyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder."],"dc:subject":["Statistical potential","Beta-Sheets"],"dc:title":["A Novel Statistical Potential for Protein Beta-Sheets Prediction"],"dc:type":["Thesis"],"thesis:degree_discipline":["Natural Sciences"],"thesis:degree_level":["Masters"],"thesis:degree_name":["Master of Science"],"thesis:institution_name":["Rice University"]},"updated_at":"2026-07-24T04:10:28Z"}