{"id":{"repo_id":"rice","oai_identifier":"oai:repository.rice.edu:1911/19235"},"canonical_url":"https://search.dev.ndltd.org/etd/rice/oai:repository.rice.edu:1911/19235","repository":{"repo_id":"rice","name":"Rice University","base_url":"https://repository.rice.edu/server/oai/request"},"display":{"title":"Synthetic studies of luzopeptins","abstract":"Luzopeptins are a series of cyclic depsipeptides which possesses potent antitumor and antiviral activities. There is no total synthesis of Luzopeptins has been achieved. In our own effort to synthesize the luzopeptins, we developed a concise and practical route to PCA, 86, and an efficient protocol to synthesize the mono-BOC, 181. A novel serinyl chloride was devised in conjunction with the formation of PCA-serine dipeptide derivatives, 164. All these methodologies were successfully applied to the synthesis of monomeric derivative of luzopeptin E$\\sb2,$ 288.* ftn*Please refer to the dissertation for diagram.","abstract_html":"Luzopeptins are a series of cyclic depsipeptides which possesses potent antitumor and antiviral activities. There is no total synthesis of Luzopeptins has been achieved. In our own effort to synthesize the luzopeptins, we developed a concise and practical route to PCA, 86, and an efficient protocol to synthesize the mono-BOC, 181. A novel serinyl chloride was devised in conjunction with the formation of PCA-serine dipeptide derivatives, 164. All these methodologies were successfully applied to the synthesis of monomeric derivative of luzopeptin E$\\sb2,$ 288.* ftn*Please refer to the dissertation for diagram.","abstract_has_math":true,"creators":["Xi, Ning"],"institution":"Rice University","degree_name":"Doctor of Philosophy","degree_level":"Doctoral","degree_discipline":"Natural Sciences","degree_department":null,"school":null,"contributors":[],"advisors":["Ciufolini, Marco A."],"committee_chairs":[],"committee_members":[],"year":1997,"date_issued":"1997","date_published":"1997","updated_at":"2026-07-24T04:10:17Z","subjects":["Organic chemistry"],"languages":["eng"],"rights":["Copyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/1911/19235","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Ciufolini, Marco A."]},{"key":"dc:creator","label":"Author","values":["Xi, Ning"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2009-06-04T08:32:43Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2009-06-04T08:32:43Z"]},{"key":"dc:date.issued","label":"Date","values":["1997"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Natural Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Doctoral"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Rice University"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Organic chemistry"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright is held by the author, unless otherwise indicated. 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