{"id":{"repo_id":"rice","oai_identifier":"oai:repository.rice.edu:1911/16751"},"canonical_url":"https://search.dev.ndltd.org/etd/rice/oai:repository.rice.edu:1911/16751","repository":{"repo_id":"rice","name":"Rice University","base_url":"https://repository.rice.edu/server/oai/request"},"display":{"title":"Synthetic studies towards the total synthesis of discorhabdin C","abstract":"Two synthetic approaches towards the total synthesis of discorhabdin C (3) are described. The general strategy for construction of azacarbocyclic spiro dienone system is to employ an intramolecular para-phenolic alkylation (58 to 43). The key reaction for the first approach is a newly improved aromatic Claisen rearrangement. The key reaction for the second approach is a novel tin-mediated indole synthesis developed in our laboratory.(DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI)","abstract_html":"Two synthetic approaches towards the total synthesis of discorhabdin C (3) are described. The general strategy for construction of azacarbocyclic spiro dienone system is to employ an intramolecular para-phenolic alkylation (58 to 43). The key reaction for the first approach is a newly improved aromatic Claisen rearrangement. The key reaction for the second approach is a novel tin-mediated indole synthesis developed in our laboratory.(DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI)","abstract_has_math":false,"creators":["Li, Tangqing"],"institution":"Rice University","degree_name":"Doctor of Philosophy","degree_level":"Doctoral","degree_discipline":"Natural Sciences","degree_department":null,"school":null,"contributors":[],"advisors":["Fukuyama, Tohru"],"committee_chairs":[],"committee_members":[],"year":1994,"date_issued":"1994","date_published":"1994","updated_at":"2026-07-24T04:10:19Z","subjects":["Organic chemistry","Biochemistry"],"languages":["eng"],"rights":["Copyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/1911/16751","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Fukuyama, Tohru"]},{"key":"dc:creator","label":"Author","values":["Li, Tangqing"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2009-06-03T23:53:52Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2009-06-03T23:53:52Z"]},{"key":"dc:date.issued","label":"Date","values":["1994"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Natural Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Doctoral"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Rice University"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Organic chemistry","Biochemistry"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/1911/16751"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Two synthetic approaches towards the total synthesis of discorhabdin C (3) are described. The general strategy for construction of azacarbocyclic spiro dienone system is to employ an intramolecular para-phenolic alkylation (58 to 43). The key reaction for the first approach is a newly improved aromatic Claisen rearrangement. The key reaction for the second approach is a novel tin-mediated indole synthesis developed in our laboratory.(DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI)"]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Synthetic studies towards the total synthesis of discorhabdin C"]}]}],"canonical_facts":{"dc:contributor.advisor":["Fukuyama, Tohru"],"dc:creator":["Li, Tangqing"],"dc:date.accessioned":["2009-06-03T23:53:52Z"],"dc:date.available":["2009-06-03T23:53:52Z"],"dc:date.issued":["1994"],"dc:description.abstract":["Two synthetic approaches towards the total synthesis of discorhabdin C (3) are described. The general strategy for construction of azacarbocyclic spiro dienone system is to employ an intramolecular para-phenolic alkylation (58 to 43). The key reaction for the first approach is a newly improved aromatic Claisen rearrangement. The key reaction for the second approach is a novel tin-mediated indole synthesis developed in our laboratory.(DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI)"],"dc:format.mimetype":["application/pdf"],"dc:identifier.uri":["https://hdl.handle.net/1911/16751"],"dc:language.iso":["eng"],"dc:rights":["Copyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder."],"dc:subject":["Organic chemistry","Biochemistry"],"dc:title":["Synthetic studies towards the total synthesis of discorhabdin C"],"dc:type":["Thesis"],"thesis:degree_discipline":["Natural Sciences"],"thesis:degree_level":["Doctoral"],"thesis:degree_name":["Doctor of Philosophy"],"thesis:institution_name":["Rice University"]},"updated_at":"2026-07-24T04:10:19Z"}