{"id":{"repo_id":"rice","oai_identifier":"oai:repository.rice.edu:1911/13860"},"canonical_url":"https://search.dev.ndltd.org/etd/rice/oai:repository.rice.edu:1911/13860","repository":{"repo_id":"rice","name":"Rice University","base_url":"https://repository.rice.edu/server/oai/request"},"display":{"title":"Synthesis of optically pure mitomycin C: A new route to FR900482","abstract":"Optically pure mitomycin C was synthesized in 28 steps and 5% overall yield from 2,6-dimethoxytoluene. The route followed was a variation upon previous work in our laboratories and the asymmetry was achieved by the resolution of racemic mitomycin A, an advanced intermediate. Our efforts at finding a new route to an intermediate in the synthesis of FR900482, are also described here. 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