Association between CSF Biomarkers and Performance on Neuropsychological Test in Patients with Mild Cognitive Impairment

Individuals with Alzheimer’s disease (AD) usually have decreased Aβ42 but increased total-tau (T-tau) and phosphorylated tau (P-Tau) in cerebrospinal fluid (CSF). To increase prognostic specificity of MCI to AD, studies have linked findings in CSF to neuropsychological profiles in MCI. The aim of this research was to find out if there is an association between critical biomarkers, such as tau and Aβ42 in the CSF, and performance on neuropsychological tests. All participants were referred to Landakot Memory Clinic by their general practitioner (N=55). The average age was 69 (SD=9.6). Mean education in years was 12.96 (SD=4). Inclusion criteria for the MCI study was a Mini Mental State Examination (MMSE) score of ≥24 and 3.2 to 4.0 on The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE). Results show that individuals with low levels of CSF Aβ42 and high levels of CSF T-tau performed worse on neuropsychological assessment representing episodic memory. Furthermore, individuals with higher education perform better on one of the neuropsychological assessment representing episodic memory, compared to those with lower education. There was no interaction effect between education and T-tau on neuropsychological assessment representing episodic memory.

Author dc:creator

• María Liv Biglio 1991-

Contributors dc:contributor

• Háskólinn í Reykjavík

• Sálfræði
• Heilabilun
• Taugasálfræði
• Psychology
• Alzheimer's disease
• Neuropsychology

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/1946/30703

OAI identifier oai:identifier

oai:skemman.is:1946/30703