{"id":{"repo_id":"radboud","oai_identifier":"oai:repository.ubn.ru.nl:2066/99159"},"canonical_url":"https://search.dev.ndltd.org/etd/radboud/oai:repository.ubn.ru.nl:2066/99159","repository":{"repo_id":"radboud","name":"Radboud University Nijmegen","base_url":"https://repository.ubn.ru.nl/oai/request"},"display":{"title":"Mimicking the micro-environment. 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For these biomaterials, it is important to use highly purified components in order to moderate the tissue response and to control the regeneration process. Using type I collagen, elastin, glycosaminoglycans and a variety of growth factors as basic components, a wide variety of biomaterials can be prepared. The purpose of this thesis is to design, develop and evaluate a new molecularly defined skin construct that closely mimics normal tissue. A biologically active growth factor was made for that reason. Different biomaterials were developed and tested in laboratory animals to evaluate tissue reaction, calcification and vascularization. Following these results, a skin construct was made and analyzed in an animal model for acute wounds. First results are promising for future development.","Radboud Universiteit Nijmegen, 19 oktober 2012","Promotores : Brock, R.E., Schalkwijk, J. 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