{"id":{"repo_id":"radboud","oai_identifier":"oai:repository.ubn.ru.nl:2066/52284"},"canonical_url":"https://search.dev.ndltd.org/etd/radboud/oai:repository.ubn.ru.nl:2066/52284","repository":{"repo_id":"radboud","name":"Radboud University Nijmegen","base_url":"https://repository.ubn.ru.nl/oai/request"},"display":{"title":"Human subfertility: explorative studies on some pathophysiologic factors in semen and follicular fluid.","abstract":"Contains fulltext : 52284.pdf (Publisher’s version ) (Open Access)","abstract_html":"Contains fulltext : 52284.pdf (Publisher’s version ) (Open Access)","abstract_has_math":false,"creators":["Ebisch, I.M.W."],"institution":"[S.l.] : [S.n.]","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Braat, D.D.M.","Steegers-Theunissen, R.P.M.","Thomas, C.M.G."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2007,"date_issued":"2007","date_published":"2007","updated_at":"2026-07-24T04:03:01Z","subjects":["UMCN 5.2: Endocrinology and reproduction"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["9090212167"],"render_values":[{"text":"9090212167","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2066/52284","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Braat, D.D.M.","Steegers-Theunissen, R.P.M.","Thomas, C.M.G."]},{"key":"dc:creator","label":"Author","values":["Ebisch, I.M.W."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2007"]},{"key":"dc:publisher","label":"Institution","values":["[S.l.] : [S.n.]"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["UMCN 5.2: Endocrinology and reproduction"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://repository.ubn.ru.nl//bitstream/handle/2066/52284/52284.pdf","http://hdl.handle.net/2066/52284","9090212167"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Contains fulltext : 52284.pdf (Publisher’s version ) (Open Access)","Subfertility is defined as failure to conceive after 1 year of regular, unprotected intercourse with the same partner. It is a prevalent disorder affecting 10-17% of all couples in the Western world. The WHO reports that in 20% of cases the cause of subfertility is originating from the male, and in 38% is mainly of female origin. In 27% fertility abnormalities are found in both partners. Although there are many known causes of subfertility, ranging from congenital, genetic, endocrine, infective and environmental factors, in up to 15% of couples the aetiology of subfertility remains unknown. Since involuntary childlessness is a heavy burden for most subfertile couples, many seek help in the form of in vitro fertilization or intracytoplasmic sperm injection to achieve pregnancy. Although these techniques have improved the treatment of subfertility, the success rate is still low (around 25%), and hardly any alternative treatment options exist. Moreover, these techniques are a symptomatic, rather than a causal treatment for subfertility. Targeted treatment and, possibly, prevention of subfertility is indicated. To that end we need more knowledge of the pathophysiology and the causal determinants of subfertility. Of particular interest are the environmental and lifestyle factors implicated in subfertility, because these can be targeted for curative or preventive measures. A significant but largely neglected lifestyle factor is nutrition, being a source of micronutrients, and exogeneous antioxidants. Also, several endogenously synthesized antioxidants are essential. Furthermore, it is hypothesized in literature that matrix degradation by the plasminogen activator system and vascularization induced by the vascular endothelial growth factor (VEGF) are causally involved in subfertility. Part I of this thesis focuses on the role of folic acid and zinc sulphate on sperm parameters, while Part II of this thesis discusses the role of antioxidants, the plasminogen activator system and VEGF.","RU Radboud Universiteit Nijmegen, 08 februari 2007","Promotor : Braat, D.D.M. Co-promotores : Steegers-Theunissen, R.P.M., Thomas, C.M.G.","232 p."]},{"key":"dc:title","label":"Title","values":["Human subfertility: explorative studies on some pathophysiologic factors in semen and follicular fluid."]}]}],"canonical_facts":{"dc:contributor":["Braat, D.D.M.","Steegers-Theunissen, R.P.M.","Thomas, C.M.G."],"dc:creator":["Ebisch, I.M.W."],"dc:date":["2007"],"dc:description":["Contains fulltext : 52284.pdf (Publisher’s version ) (Open Access)","Subfertility is defined as failure to conceive after 1 year of regular, unprotected intercourse with the same partner. It is a prevalent disorder affecting 10-17% of all couples in the Western world. The WHO reports that in 20% of cases the cause of subfertility is originating from the male, and in 38% is mainly of female origin. In 27% fertility abnormalities are found in both partners. Although there are many known causes of subfertility, ranging from congenital, genetic, endocrine, infective and environmental factors, in up to 15% of couples the aetiology of subfertility remains unknown. Since involuntary childlessness is a heavy burden for most subfertile couples, many seek help in the form of in vitro fertilization or intracytoplasmic sperm injection to achieve pregnancy. Although these techniques have improved the treatment of subfertility, the success rate is still low (around 25%), and hardly any alternative treatment options exist. Moreover, these techniques are a symptomatic, rather than a causal treatment for subfertility. Targeted treatment and, possibly, prevention of subfertility is indicated. To that end we need more knowledge of the pathophysiology and the causal determinants of subfertility. Of particular interest are the environmental and lifestyle factors implicated in subfertility, because these can be targeted for curative or preventive measures. A significant but largely neglected lifestyle factor is nutrition, being a source of micronutrients, and exogeneous antioxidants. Also, several endogenously synthesized antioxidants are essential. Furthermore, it is hypothesized in literature that matrix degradation by the plasminogen activator system and vascularization induced by the vascular endothelial growth factor (VEGF) are causally involved in subfertility. Part I of this thesis focuses on the role of folic acid and zinc sulphate on sperm parameters, while Part II of this thesis discusses the role of antioxidants, the plasminogen activator system and VEGF.","RU Radboud Universiteit Nijmegen, 08 februari 2007","Promotor : Braat, D.D.M. 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