{"id":{"repo_id":"radboud","oai_identifier":"oai:repository.ubn.ru.nl:2066/332599"},"canonical_url":"https://search.dev.ndltd.org/etd/radboud/oai:repository.ubn.ru.nl:2066/332599","repository":{"repo_id":"radboud","name":"Radboud University Nijmegen","base_url":"https://repository.ubn.ru.nl/oai/request"},"display":{"title":"The first anatomically shaped meniscus prosthesis: Improving biomechanical performance and clinical outcomes","abstract":"Contains fulltext : 332599.pdf (Publisher’s version ) (Closed access)","abstract_html":"Contains fulltext : 332599.pdf (Publisher’s version ) (Closed access)","abstract_has_math":false,"creators":["Minnen, B.S. van"],"institution":"S.l. : s.n.","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Verdonschot, N.J.J.","Groes, S.A.W. van de","Tienen, T.G. van"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2026,"date_issued":"2026","date_published":"2026","updated_at":"2026-07-24T04:00:43Z","subjects":["Orthopaedics - Radboud University Medical Center"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["9789465373324"],"render_values":[{"text":"9789465373324","href":null,"code":true}]}]},"links":{"outbound_url":"https://hdl.handle.net/2066/332599","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Verdonschot, N.J.J.","Groes, S.A.W. van de","Tienen, T.G. van"]},{"key":"dc:creator","label":"Author","values":["Minnen, B.S. van"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2026"]},{"key":"dc:publisher","label":"Institution","values":["S.l. : s.n."]},{"key":"dc:type","label":"Dc Type","values":["Doctoral thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Orthopaedics - Radboud University Medical Center"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2066/332599","9789465373324"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Contains fulltext : 332599.pdf (Publisher’s version ) (Closed access)","This thesis presents the development and evaluation of the first anatomically shaped meniscus prosthesis, aimed at restoring knee function after meniscectomy and improving clinical outcomes in patients with post-meniscectomy pain syndrome. The meniscus plays a key role in load transmission, joint stability, lubrication, and protection of cartilage. Its removal often leads to increased contact pressures, pain, and a higher risk of osteoarthritis. Current treatment options, such as meniscal repair and allograft transplantation, are limited by feasibility, availability, and variable long-term outcomes. This research addresses the need for an off-the-shelf solution by developing a synthetic total replacement based on anatomical and biomechanical principles – the Artimis® meniscus prosthesis. The thesis combines pre-clinical and clinical studies to evaluate different generations of the medial meniscus prosthesis. Early clinical results showed that the first-generation implant had a high failure rate due to stiffness and fixation limitations, highlighting the importance of flexibility and load sharing. Subsequent design iterations led to a flexible, second-generation prosthesis with improved biomechanical performance. Experimental studies demonstrate that the flexible prosthesis can partially restore contact mechanics after meniscectomy and mimic native meniscus kinematics. Additionally, it contributes to shock absorption and damping capacity within the knee joint. Early clinical findings indicate potential for pain relief, although further optimization and long-term validation are required. Overall, this work provides a comprehensive framework for the design, evaluation, and clinical translation of meniscus prostheses, contributing to the development of effective joint-preserving treatments.","Radboud University, 04 september 2026","Promotor : Verdonschot, N.J.J. Co-promotores : Groes, S.A.W. van de, Tienen, T.G. van","184 p."]},{"key":"dc:title","label":"Title","values":["The first anatomically shaped meniscus prosthesis: Improving biomechanical performance and clinical outcomes"]}]}],"canonical_facts":{"dc:contributor":["Verdonschot, N.J.J.","Groes, S.A.W. van de","Tienen, T.G. van"],"dc:creator":["Minnen, B.S. van"],"dc:date":["2026"],"dc:description":["Contains fulltext : 332599.pdf (Publisher’s version ) (Closed access)","This thesis presents the development and evaluation of the first anatomically shaped meniscus prosthesis, aimed at restoring knee function after meniscectomy and improving clinical outcomes in patients with post-meniscectomy pain syndrome. The meniscus plays a key role in load transmission, joint stability, lubrication, and protection of cartilage. Its removal often leads to increased contact pressures, pain, and a higher risk of osteoarthritis. Current treatment options, such as meniscal repair and allograft transplantation, are limited by feasibility, availability, and variable long-term outcomes. This research addresses the need for an off-the-shelf solution by developing a synthetic total replacement based on anatomical and biomechanical principles – the Artimis® meniscus prosthesis. The thesis combines pre-clinical and clinical studies to evaluate different generations of the medial meniscus prosthesis. Early clinical results showed that the first-generation implant had a high failure rate due to stiffness and fixation limitations, highlighting the importance of flexibility and load sharing. Subsequent design iterations led to a flexible, second-generation prosthesis with improved biomechanical performance. Experimental studies demonstrate that the flexible prosthesis can partially restore contact mechanics after meniscectomy and mimic native meniscus kinematics. Additionally, it contributes to shock absorption and damping capacity within the knee joint. Early clinical findings indicate potential for pain relief, although further optimization and long-term validation are required. Overall, this work provides a comprehensive framework for the design, evaluation, and clinical translation of meniscus prostheses, contributing to the development of effective joint-preserving treatments.","Radboud University, 04 september 2026","Promotor : Verdonschot, N.J.J. Co-promotores : Groes, S.A.W. van de, Tienen, T.G. van","184 p."],"dc:identifier":["https://hdl.handle.net/2066/332599","9789465373324"],"dc:publisher":["S.l. : s.n."],"dc:subject":["Orthopaedics - Radboud University Medical Center"],"dc:title":["The first anatomically shaped meniscus prosthesis: Improving biomechanical performance and clinical outcomes"],"dc:type":["Doctoral thesis"]},"updated_at":"2026-07-24T04:00:43Z"}