{"id":{"repo_id":"radboud","oai_identifier":"oai:repository.ubn.ru.nl:2066/323969"},"canonical_url":"https://search.dev.ndltd.org/etd/radboud/oai:repository.ubn.ru.nl:2066/323969","repository":{"repo_id":"radboud","name":"Radboud University Nijmegen","base_url":"https://repository.ubn.ru.nl/oai/request"},"display":{"title":"Mimicking the Regenerative Matrix: Bioactive Scaffolds to Improve Skin Repair","abstract":"Contains fulltext : 323969.pdf (Publisher’s version ) (Closed access)","abstract_html":"Contains fulltext : 323969.pdf (Publisher’s version ) (Closed access)","abstract_has_math":false,"creators":["Avila Martinez, N.M."],"institution":"Nijmegen : Radboud University Press","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Daamen, W.F.","Kuppevelt, A.H.M.S.M. van","Boekema, B.K.H.L."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025","date_published":"2025","updated_at":"2026-07-24T04:01:17Z","subjects":["Radboud Dissertation Series","Medical Biosciences - Radboud University Medical Center"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.54195/9789465151564","9789465151564","Radboud Dissertation Series,"],"render_values":[{"text":"10.54195/9789465151564","href":"https://doi.org/10.54195/9789465151564","code":true},{"text":"9789465151564","href":null,"code":true},{"text":"Radboud Dissertation Series,","href":null,"code":true}]}]},"links":{"outbound_url":"https://hdl.handle.net/2066/323969","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Daamen, W.F.","Kuppevelt, A.H.M.S.M. van","Boekema, B.K.H.L."]},{"key":"dc:creator","label":"Author","values":["Avila Martinez, N.M."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025"]},{"key":"dc:publisher","label":"Institution","values":["Nijmegen : Radboud University Press"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Radboud Dissertation Series","Medical Biosciences - Radboud University Medical Center"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2066/323969","10.54195/9789465151564","9789465151564","Radboud Dissertation Series,"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Contains fulltext : 323969.pdf (Publisher’s version ) (Closed access)","Severe deep skin wounds, such as burns, often heal with scars that contract, limiting mobility and quality of life. Current dermal templates are unable to prevent these complications. This thesis describes the development of new biomaterials inspired by species whose skin heals without scarring. Three prototypes were designed by enriching type I collagen matrices with proteins, chains of disaccharides (glycosaminoglycans), and effector molecules: extracellular matrix components that play key roles in natural regeneration. The tests showed encouraging results: reduced expression of scarring-related genes, activation of pro-healing cells, and less wound contraction. These outcomes demonstrate that biomaterials tailored with regenerative cues can improve healing compared to existing therapies. This work contributes innovative strategies for wound care, aimed at restoring function, preventing contractures, and improving the long-term recovery of patients with severe injuries.","Radboud University, 27 oktober 2025","Promotor : Daamen, W.F. Co-promotores : Kuppevelt, A.H.M.S.M. van, Boekema, B.K.H.L.","208 p."]},{"key":"dc:title","label":"Title","values":["Mimicking the Regenerative Matrix: Bioactive Scaffolds to Improve Skin Repair"]}]}],"canonical_facts":{"dc:contributor":["Daamen, W.F.","Kuppevelt, A.H.M.S.M. van","Boekema, B.K.H.L."],"dc:creator":["Avila Martinez, N.M."],"dc:date":["2025"],"dc:description":["Contains fulltext : 323969.pdf (Publisher’s version ) (Closed access)","Severe deep skin wounds, such as burns, often heal with scars that contract, limiting mobility and quality of life. Current dermal templates are unable to prevent these complications. This thesis describes the development of new biomaterials inspired by species whose skin heals without scarring. Three prototypes were designed by enriching type I collagen matrices with proteins, chains of disaccharides (glycosaminoglycans), and effector molecules: extracellular matrix components that play key roles in natural regeneration. 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