{"id":{"repo_id":"radboud","oai_identifier":"oai:repository.ubn.ru.nl:2066/19574"},"canonical_url":"https://search.dev.ndltd.org/etd/radboud/oai:repository.ubn.ru.nl:2066/19574","repository":{"repo_id":"radboud","name":"Radboud University Nijmegen","base_url":"https://repository.ubn.ru.nl/oai/request"},"display":{"title":"Targeting of IL-1 and IL-18 in experimental arthritis using soluble receptors - A gene thereapeutic approach.","abstract":"Contains fulltext : 19574.pdf (Publisher’s version ) (Open Access)","abstract_html":"Contains fulltext : 19574.pdf (Publisher’s version ) (Open Access)","abstract_has_math":false,"creators":["Smeets, R."],"institution":"S.l. : s.n.","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Berg, W.B. van den","Loo, A.A.J. van de"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2005,"date_issued":"2005","date_published":"2005","updated_at":"2026-07-24T04:01:52Z","subjects":["UMCN 4.2: Chronic inflammation and autoimmunity"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2066/49065","9090188908"],"render_values":[{"text":"http://hdl.handle.net/2066/49065","href":"http://hdl.handle.net/2066/49065","code":true},{"text":"9090188908","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2066/19574","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Berg, W.B. van den","Loo, A.A.J. van de"]},{"key":"dc:creator","label":"Author","values":["Smeets, R."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2005"]},{"key":"dc:publisher","label":"Institution","values":["S.l. : s.n."]},{"key":"dc:type","label":"Dc Type","values":["Doctoral thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["UMCN 4.2: Chronic inflammation and autoimmunity"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://repository.ubn.ru.nl//bitstream/handle/2066/19574/19574.pdf","http://hdl.handle.net/2066/19574","http://hdl.handle.net/2066/49065","9090188908"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Contains fulltext : 19574.pdf (Publisher’s version ) (Open Access)","Both IL-1 and IL-18 are important proinflammatory cytokines, which play an important role in the initiation and maintenance of inflammatory processes for instance during RA. As it appears, this process of IL-1/IL-18 signal transduction is tightly regulated at receptor level, by membrane associated decoy receptors and soluble receptor antagonists. However, the exact physiological role of the recently described natural occurring murine soluble receptors,like sIL-1RAcP, sIL-18Rß and the IL-18BP, which are partial analogues of the membrane signaling receptors, needs to be further elucidated. 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