{"id":{"repo_id":"queens","oai_identifier":"oai:queensu.scholaris.ca:1974/5109"},"canonical_url":"https://search.dev.ndltd.org/etd/queens/oai:queensu.scholaris.ca:1974/5109","repository":{"repo_id":"queens","name":"Queens University","base_url":"https://qspace.library.queensu.ca/server/oai/request"},"display":{"title":"Synthesis of photochemically active complexes for DNA recognition and binding","abstract":"The objective of this thesis is to synthesize and examine the photophysical and structural properties of 3-(pyridin-2-yl)imidazo[1,5-a]pyridine (P) and 3-(pyridin-2-yl)imidazo [1,5-a]pyridine (IQ) based cations and their potential use as DNA binding agents. The P ligand was aimed to compare with the IQ ligand as they have similar structures. Two series of compounds were synthesized; one series comprising organic cations, including PC2, PC3, PC4, IQC2 and IQC3. The other one contains ruthenium complexes Ru(bpy)2P, Ru(bpy)2IQ and Ru(P)3). Compounds were prepared as Cl-, Br- and/or PF6- salts. All compounds were characterized by NMR, UV-vis, luminescescence and electrochemistry, when applicable. The results show that P and IQ based organic cations have similar electrochemical properties, and may be candidates for guanine photo-oxidation. However, [Ru(bpy)2P](PF6)2, [Ru(bpy)2IQ](PF6)2 and [Ru(P)3](PF6)2 do not seem to have reduction potentials in the excited states that are appropriate for nucleic base photo-oxidation.","abstract_html":"The objective of this thesis is to synthesize and examine the photophysical and structural properties of 3-(pyridin-2-yl)imidazo[1,5-a]pyridine (P) and 3-(pyridin-2-yl)imidazo [1,5-a]pyridine (IQ) based cations and their potential use as DNA binding agents. The P ligand was aimed to compare with the IQ ligand as they have similar structures. Two series of compounds were synthesized; one series comprising organic cations, including PC2, PC3, PC4, IQC2 and IQC3. The other one contains ruthenium complexes Ru(bpy)2P, Ru(bpy)2IQ and Ru(P)3). Compounds were prepared as Cl-, Br- and/or PF6- salts. All compounds were characterized by NMR, UV-vis, luminescescence and electrochemistry, when applicable. The results show that P and IQ based organic cations have similar electrochemical properties, and may be candidates for guanine photo-oxidation. However, [Ru(bpy)2P](PF6)2, [Ru(bpy)2IQ](PF6)2 and [Ru(P)3](PF6)2 do not seem to have reduction potentials in the excited states that are appropriate for nucleic base photo-oxidation.","abstract_has_math":false,"creators":["Luo, Jingwei"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":"Chemistry","school":null,"contributors":[],"advisors":["Petitjean, Anne"],"committee_chairs":[],"committee_members":[],"year":2009,"date_issued":"2009-09-01T23:31:12Z","date_published":"2009-09-01T23:31:12Z","updated_at":"2026-07-27T20:35:21Z","subjects":["DNA recognition","photoadduct"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/1974/5109","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.department","label":"Department","values":["Chemistry"]},{"key":"dc:contributor.supervisor","label":"Supervisor","values":["Petitjean, Anne"]},{"key":"dc:creator","label":"Author","values":["Luo, Jingwei"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2009-09-01 11:58:42.728"]},{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2009-09-01T23:31:12Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2009-09-01T23:31:12Z"]},{"key":"dc:date.issued","label":"Date","values":["2009-09-01T23:31:12Z"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["DNA recognition","photoadduct"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/1974/5109"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Thesis (Master, Chemistry) -- Queen's University, 2009-09-01 11:58:42.728"]},{"key":"dc:description.abstract","label":"Abstract","values":["The objective of this thesis is to synthesize and examine the photophysical and structural properties of 3-(pyridin-2-yl)imidazo[1,5-a]pyridine (P) and 3-(pyridin-2-yl)imidazo [1,5-a]pyridine (IQ) based cations and their potential use as DNA binding agents. The P ligand was aimed to compare with the IQ ligand as they have similar structures. Two series of compounds were synthesized; one series comprising organic cations, including PC2, PC3, PC4, IQC2 and IQC3. The other one contains ruthenium complexes Ru(bpy)2P, Ru(bpy)2IQ and Ru(P)3). Compounds were prepared as Cl-, Br- and/or PF6- salts. All compounds were characterized by NMR, UV-vis, luminescescence and electrochemistry, when applicable. The results show that P and IQ based organic cations have similar electrochemical properties, and may be candidates for guanine photo-oxidation. However, [Ru(bpy)2P](PF6)2, [Ru(bpy)2IQ](PF6)2 and [Ru(P)3](PF6)2 do not seem to have reduction potentials in the excited states that are appropriate for nucleic base photo-oxidation."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["M.Sc."]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Synthesis of photochemically active complexes for DNA recognition and binding"]}]}],"canonical_facts":{"dc:contributor.department":["Chemistry"],"dc:contributor.supervisor":["Petitjean, Anne"],"dc:creator":["Luo, Jingwei"],"dc:date":["2009-09-01 11:58:42.728"],"dc:date.accessioned":["2009-09-01T23:31:12Z"],"dc:date.available":["2009-09-01T23:31:12Z"],"dc:date.issued":["2009-09-01T23:31:12Z"],"dc:description":["Thesis (Master, Chemistry) -- Queen's University, 2009-09-01 11:58:42.728"],"dc:description.abstract":["The objective of this thesis is to synthesize and examine the photophysical and structural properties of 3-(pyridin-2-yl)imidazo[1,5-a]pyridine (P) and 3-(pyridin-2-yl)imidazo [1,5-a]pyridine (IQ) based cations and their potential use as DNA binding agents. The P ligand was aimed to compare with the IQ ligand as they have similar structures. Two series of compounds were synthesized; one series comprising organic cations, including PC2, PC3, PC4, IQC2 and IQC3. The other one contains ruthenium complexes Ru(bpy)2P, Ru(bpy)2IQ and Ru(P)3). Compounds were prepared as Cl-, Br- and/or PF6- salts. All compounds were characterized by NMR, UV-vis, luminescescence and electrochemistry, when applicable. The results show that P and IQ based organic cations have similar electrochemical properties, and may be candidates for guanine photo-oxidation. However, [Ru(bpy)2P](PF6)2, [Ru(bpy)2IQ](PF6)2 and [Ru(P)3](PF6)2 do not seem to have reduction potentials in the excited states that are appropriate for nucleic base photo-oxidation."],"dc:description.degree":["M.Sc."],"dc:format.mimetype":["application/pdf"],"dc:identifier.uri":["http://hdl.handle.net/1974/5109"],"dc:language.iso":["eng"],"dc:subject":["DNA recognition","photoadduct"],"dc:title":["Synthesis of photochemically active complexes for DNA recognition and binding"],"dc:type":["thesis"]},"updated_at":"2026-07-27T20:35:21Z"}