Engineering of Light-Gated Artificial Ion Channels

The goal of this project is the development of artificial ion channels that can be actuated by light and thus controlled efficiently. Our artificial system is composed of two regions: the gate and the body part. The gate part is based on light-responsive azo groups while the body part is formed by calix[4]resorcinarene. Key of controlling mechanism is the conformational change between cis and trans isomers, which is translated into movement of the gate. Light-gated artificial ion channels are aimed at eliminating of the stochastic mechanism of artificial ion channels. Such a reversible photocontrol should be a powerful tool for using artificial ion channels as the basis for the development of new pharmaceuticals and drug delivery systems, as photoswitches, and in the field of microfluidics.

Level thesis:degree_level

thesis.doctoral

Grantor dc:publisher

Technische Universität Dresden

Year

2006

Author dc:creator

• Steller, Laura Florentina

Contributors dc:contributor

• Salzer, Reiner
• Habicher, Wolf Dieter
• Rissanen, Kari

• artificial ion channel
• calixresorcinarene
• light switchable gate
• patch clamp
• künstliche Ionenkanäle
• photogesteuerter Verschluss