Development and validation of ultra-high performance liquid chromatography-tandem mass spectrometry methods for screening of selective androgen receptor modulators in urine and blood
type: CreativeWork
description: Anabolic-androgenic steroids (AAS) continue to be the drug class most abused amongst athletes, and despite the fact that adverse effects from pseudo-endogenous and synthetic AAS misuse are well known, the potential for irreversible effects on human health to be induced by AAS is still not sufficient to eliminate their abuse. Even as anti-doping laboratories have achieved significant advancements in the analytical performance of antidoping testing and established a deep knowledge of steroid profiles in humans, athletes continue to cheat and exploit the properties of emerging novel anabolic drug enhancers namely selective androgen receptor modulators (SARMs). SARMs were discovered in the late 1990s as promising alternatives to AAS due to their ability to separate anabolic effects on target tissues from unwanted androgenic effects. Nowadays, the potential therapeutic applications of SARM compounds has focussed on a range of human conditions including those involving muscle or bone wasting. Despite the fact that no SARM pharmacophore has yet received approval for clinical use in humans, they can still be easily accessed and sourced on the black market, being well recognised as drugs of abuse to enhance performance in both human and animal sports, and have also been suggested to potentially find use in foodproducing species to increase meat yield and production efficiency. In response to the illicit use of SARMs through doping and food fraud practices, SARMs are banned in human and equine sport by the World Anti-Doping Agency (WADA), the International Federation of Horseracing Authorities (IFHA) and the Fédération Equestre Internationale (International Equestrian Federation, FEI), as well as under EU Council Directive 88/146/EEC for animal husbandry use. The research presented here has sought to address the lack of multi-residue analytical methods enabling the effective detection of emerging SARM compounds in a range of biofluids collected from different animal species. …
abstract: Anabolic-androgenic steroids (AAS) continue to be the drug class most abused amongst athletes, and despite the fact that adverse effects from pseudo-endogenous and synthetic AAS misuse are well known, the potential for irreversible effects on human health to be induced by AAS is still not sufficient to eliminate their abuse. Even as anti-doping laboratories have achieved significant advancements in the analytical performance of antidoping testing and established a deep knowledge of steroid profiles in humans, athletes continue to cheat and exploit the properties of emerging novel anabolic drug enhancers namely selective androgen receptor modulators (SARMs). SARMs were discovered in the late 1990s as promising alternatives to AAS due to their ability to separate anabolic effects on target tissues from unwanted androgenic effects. Nowadays, the potential therapeutic applications of SARM compounds has focussed on a range of human conditions including those involving muscle or bone wasting. Despite the fact that no SARM pharmacophore has yet received approval for clinical use in humans, they can still be easily accessed and sourced on the black market, being well recognised as drugs of abuse to enhance performance in both human and animal sports, and have also been suggested to potentially find use in foodproducing species to increase meat yield and production efficiency. In response to the illicit use of SARMs through doping and food fraud practices, SARMs are banned in human and equine sport by the World Anti-Doping Agency (WADA), the International Federation of Horseracing Authorities (IFHA) and the Fédération Equestre Internationale (International Equestrian Federation, FEI), as well as under EU Council Directive 88/146/EEC for animal husbandry use. The research presented here has sought to address the lack of multi-residue analytical methods enabling the effective detection of emerging SARM compounds in a range of biofluids collected from different animal species. …
author: Ventura, Emiliano
language: eng
keywords: selective androgen receptor modulators, SARMs, blood, urine, UHPLC-MS/MS, anti-doping control, food safety monitoring, residue analysis
date published: 2020-7
date modified: 2026-07-24T03:55:25Z
provider: Queen's University Belfast
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Queen's University Belfast