{"id":{"repo_id":"qu-belfast","oai_identifier":"oai:pure.qub.ac.uk/portal:studenttheses/8bac59e2-6d26-4060-8ecf-f95edb9ad128"},"canonical_url":"https://search.dev.ndltd.org/etd/qu-belfast/oai:pure.qub.ac.uk/portal:studenttheses/8bac59e2-6d26-4060-8ecf-f95edb9ad128","repository":{"repo_id":"qu-belfast","name":"Queen's University Belfast","base_url":"https://pureadmin.qub.ac.uk/ws/oai"},"display":{"title":"Fused deposition modelling three-dimensional printing of solid dosage forms","abstract":"Three-dimensional printing (3DP) is a widely used technique for the design and manufacture of complex solid dosage forms with the objective of formulating personalized medicines and on-demand manufacturing. Among commercially available models, fused deposition modelling 3D-printing (FDM-3DP) has shown the potential to fabricate objects with various internal structures and the ability to introduce multiple specific functionalities. This thesis’s main aim was to understand printability in FDM-3DP and the factors influencing it, as well as to manufacture novel gastro-retentive floating drug delivery systems through FDM-3DP using pharmaceutical excipients. Hot-melt extrusion (HME) was implemented to fabricate filaments with adequate properties for FDM-3DP. Rheological, mechanical and physical characterisation of filaments were evaluated to provide information on the impact of these properties on the FDM 3DP process. Theophylline-loaded filaments, suitable for FDM-3DP, were successfully formulated using three polymeric carriers (Polyvinyl alcohol (PVA), Hydroxypropyl Cellulose (HPC), and Soluplus®). FDM-3DP enabled the manufacture of monolithic and non-monolithic floating drug delivery systems using a sandwich design. The tablet design showed the ability to achieve prolonged gastric floating (12 hours) with no floating lag time. Formulations containing Soluplus® or HPC with Eudragit RLPO provided zero-order sustained release of theophylline (THP). Fixed-dose bilayer floating tablets were also manufactured. This thesis displayed the ability of FDM-3DP to manufacture bespoke floating tablets using pharmaceutical excipients with tailored drug release profiles.<br/><br/><i>Thesis embargoed until 31 December 2026</i>.<br/>","abstract_html":"Three-dimensional printing (3DP) is a widely used technique for the design and manufacture of complex solid dosage forms with the objective of formulating personalized medicines and on-demand manufacturing. Among commercially available models, fused deposition modelling 3D-printing (FDM-3DP) has shown the potential to fabricate objects with various internal structures and the ability to introduce multiple specific functionalities. This thesis’s main aim was to understand printability in FDM-3DP and the factors influencing it, as well as to manufacture novel gastro-retentive floating drug delivery systems through FDM-3DP using pharmaceutical excipients. Hot-melt extrusion (HME) was implemented to fabricate filaments with adequate properties for FDM-3DP. Rheological, mechanical and physical characterisation of filaments were evaluated to provide information on the impact of these properties on the FDM 3DP process. Theophylline-loaded filaments, suitable for FDM-3DP, were successfully formulated using three polymeric carriers (Polyvinyl alcohol (PVA), Hydroxypropyl Cellulose (HPC), and Soluplus®). FDM-3DP enabled the manufacture of monolithic and non-monolithic floating drug delivery systems using a sandwich design. The tablet design showed the ability to achieve prolonged gastric floating (12 hours) with no floating lag time. Formulations containing Soluplus® or HPC with Eudragit RLPO provided zero-order sustained release of theophylline (THP). Fixed-dose bilayer floating tablets were also manufactured. This thesis displayed the ability of FDM-3DP to manufacture bespoke floating tablets using pharmaceutical excipients with tailored drug release profiles.&lt;br/&gt;&lt;br/&gt;&lt;i&gt;Thesis embargoed until 31 December 2026&lt;/i&gt;.&lt;br/&gt;","abstract_has_math":false,"creators":["Oladeji, Sinmisola A."],"institution":"Queen's University Belfast","degree_name":"Doctor of Philosophy","degree_level":"Doctoral Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Andrews, Gavin","Li, Shu"],"committee_chairs":[],"committee_members":[],"year":2021,"date_issued":"2021-12","date_published":"2021-12","updated_at":"2026-07-24T03:55:58Z","subjects":["3D printing","Fused deposition modelling (FDM)","gastric floating","sustained release","zero-order release","rheology","oral solid dosage forms","fixed dose combinations"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:pure.qub.ac.uk/portal:studenttheses/8bac59e2-6d26-4060-8ecf-f95edb9ad128"],"render_values":[{"text":"oai:pure.qub.ac.uk/portal:studenttheses/8bac59e2-6d26-4060-8ecf-f95edb9ad128","href":null,"code":true}]}]},"links":{"outbound_url":"https://pure.qub.ac.uk/en/studentTheses/8bac59e2-6d26-4060-8ecf-f95edb9ad128","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Andrews, Gavin","Li, Shu"]},{"key":"dc:creator","label":"Author","values":["Oladeji, Sinmisola A."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2021-12"]},{"key":"dc:date.issued","label":"Date","values":["2021-12"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["School of Pharmacy"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["Queen's University Belfast"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://pure.qub.ac.uk/en/studentTheses/8bac59e2-6d26-4060-8ecf-f95edb9ad128"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["Doctor of Philosophy"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["3D printing","Fused deposition modelling (FDM)","gastric floating","sustained release","zero-order release","rheology","oral solid dosage forms","fixed dose combinations"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights.embargodate","label":"Dc Rights Embargodate","values":["2026-12-31"]},{"key":"dc:rights.embargoreason","label":"Dc Rights Embargoreason","values":["/dk/atira/pure/core/document/studentthesisembargoreason/publicationissues"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:pure.qub.ac.uk/portal:studenttheses/8bac59e2-6d26-4060-8ecf-f95edb9ad128","https://pure.qub.ac.uk/en/studentTheses/8bac59e2-6d26-4060-8ecf-f95edb9ad128"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Three-dimensional printing (3DP) is a widely used technique for the design and manufacture of complex solid dosage forms with the objective of formulating personalized medicines and on-demand manufacturing. Among commercially available models, fused deposition modelling 3D-printing (FDM-3DP) has shown the potential to fabricate objects with various internal structures and the ability to introduce multiple specific functionalities. This thesis’s main aim was to understand printability in FDM-3DP and the factors influencing it, as well as to manufacture novel gastro-retentive floating drug delivery systems through FDM-3DP using pharmaceutical excipients. Hot-melt extrusion (HME) was implemented to fabricate filaments with adequate properties for FDM-3DP. Rheological, mechanical and physical characterisation of filaments were evaluated to provide information on the impact of these properties on the FDM 3DP process. Theophylline-loaded filaments, suitable for FDM-3DP, were successfully formulated using three polymeric carriers (Polyvinyl alcohol (PVA), Hydroxypropyl Cellulose (HPC), and Soluplus®). FDM-3DP enabled the manufacture of monolithic and non-monolithic floating drug delivery systems using a sandwich design. The tablet design showed the ability to achieve prolonged gastric floating (12 hours) with no floating lag time. Formulations containing Soluplus® or HPC with Eudragit RLPO provided zero-order sustained release of theophylline (THP). Fixed-dose bilayer floating tablets were also manufactured. This thesis displayed the ability of FDM-3DP to manufacture bespoke floating tablets using pharmaceutical excipients with tailored drug release profiles.<br/><br/><i>Thesis embargoed until 31 December 2026</i>.<br/>"]},{"key":"dc:title","label":"Title","values":["Fused deposition modelling three-dimensional printing of solid dosage forms"]}]}],"canonical_facts":{"dc:contributor.advisor":["Andrews, Gavin","Li, Shu"],"dc:creator":["Oladeji, Sinmisola A."],"dc:date":["2021-12"],"dc:date.issued":["2021-12"],"dc:description.abstract":["Three-dimensional printing (3DP) is a widely used technique for the design and manufacture of complex solid dosage forms with the objective of formulating personalized medicines and on-demand manufacturing. Among commercially available models, fused deposition modelling 3D-printing (FDM-3DP) has shown the potential to fabricate objects with various internal structures and the ability to introduce multiple specific functionalities. This thesis’s main aim was to understand printability in FDM-3DP and the factors influencing it, as well as to manufacture novel gastro-retentive floating drug delivery systems through FDM-3DP using pharmaceutical excipients. Hot-melt extrusion (HME) was implemented to fabricate filaments with adequate properties for FDM-3DP. Rheological, mechanical and physical characterisation of filaments were evaluated to provide information on the impact of these properties on the FDM 3DP process. Theophylline-loaded filaments, suitable for FDM-3DP, were successfully formulated using three polymeric carriers (Polyvinyl alcohol (PVA), Hydroxypropyl Cellulose (HPC), and Soluplus®). FDM-3DP enabled the manufacture of monolithic and non-monolithic floating drug delivery systems using a sandwich design. The tablet design showed the ability to achieve prolonged gastric floating (12 hours) with no floating lag time. Formulations containing Soluplus® or HPC with Eudragit RLPO provided zero-order sustained release of theophylline (THP). Fixed-dose bilayer floating tablets were also manufactured. This thesis displayed the ability of FDM-3DP to manufacture bespoke floating tablets using pharmaceutical excipients with tailored drug release profiles.<br/><br/><i>Thesis embargoed until 31 December 2026</i>.<br/>"],"dc:identifier":["oai:pure.qub.ac.uk/portal:studenttheses/8bac59e2-6d26-4060-8ecf-f95edb9ad128","https://pure.qub.ac.uk/en/studentTheses/8bac59e2-6d26-4060-8ecf-f95edb9ad128"],"dc:language":["eng"],"dc:publisher.department":["School of Pharmacy"],"dc:publisher.institution":["Queen's University Belfast"],"dc:relation.isreferencedby":["https://pure.qub.ac.uk/en/studentTheses/8bac59e2-6d26-4060-8ecf-f95edb9ad128"],"dc:rights.embargodate":["2026-12-31"],"dc:rights.embargoreason":["/dk/atira/pure/core/document/studentthesisembargoreason/publicationissues"],"dc:subject":["3D printing","Fused deposition modelling (FDM)","gastric floating","sustained release","zero-order release","rheology","oral solid dosage forms","fixed dose combinations"],"dc:title":["Fused deposition modelling three-dimensional printing of solid dosage forms"],"dc:type":["Thesis"],"dc:type.qualificationlevel":["Doctoral Thesis"],"dc:type.qualificationname":["Doctor of Philosophy"]},"updated_at":"2026-07-24T03:55:58Z"}