{"id":{"repo_id":"qu-belfast","oai_identifier":"oai:pure.qub.ac.uk/portal:studenttheses/40ce0794-803f-486e-9b86-ecee08dd3dee"},"canonical_url":"https://search.dev.ndltd.org/etd/qu-belfast/oai:pure.qub.ac.uk/portal:studenttheses/40ce0794-803f-486e-9b86-ecee08dd3dee","repository":{"repo_id":"qu-belfast","name":"Queen's University Belfast","base_url":"https://pureadmin.qub.ac.uk/ws/oai"},"display":{"title":"The role of NLRP3 and AIM2 inflammasomes in dental pulp inflammation and reparative processes","abstract":"In the dental pulp, an acute inflammatory response is crucial for initiating healing and repair. The dental pulp is capable of mounting such a response by expressing sophisticated immune response components. Many studies investigated the role of different immune response components in dental pulp inflammation and repair, but the emerging role of Absent in melanoma 2 (AIM2) and Nod-like receptor protein 3 (NLRP3) inflammasomes is yet to be elucidated. <br/><br/>In this thesis, the role of AIM2 and NLPR3 receptors was explored, both in bacterial and sterile inflammation context. Furthermore, the potential of modulating the inflammatory responses via these receptors to mediate repair.<br/><br/>The findings of the thesis confirmed the importance of inflammation in dental pulp healing and repair following injury and demonstrated novel roles for NLRP3 inflammasomes and DNA sensors in this process.<br/><br/><i>Thesis is embargoed until 31 July 2026.</i>","abstract_html":"In the dental pulp, an acute inflammatory response is crucial for initiating healing and repair. The dental pulp is capable of mounting such a response by expressing sophisticated immune response components. Many studies investigated the role of different immune response components in dental pulp inflammation and repair, but the emerging role of Absent in melanoma 2 (AIM2) and Nod-like receptor protein 3 (NLRP3) inflammasomes is yet to be elucidated. &lt;br/&gt;&lt;br/&gt;In this thesis, the role of AIM2 and NLPR3 receptors was explored, both in bacterial and sterile inflammation context. Furthermore, the potential of modulating the inflammatory responses via these receptors to mediate repair.&lt;br/&gt;&lt;br/&gt;The findings of the thesis confirmed the importance of inflammation in dental pulp healing and repair following injury and demonstrated novel roles for NLRP3 inflammasomes and DNA sensors in this process.&lt;br/&gt;&lt;br/&gt;&lt;i&gt;Thesis is embargoed until 31 July 2026.&lt;/i&gt;","abstract_has_math":false,"creators":["Al-Natour, Banan"],"institution":"Queen's University Belfast","degree_name":"Doctor of Philosophy","degree_level":"Doctoral Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["El Karim, Ikhlas","Dombrowski, Yvonne"],"committee_chairs":[],"committee_members":[],"year":2021,"date_issued":"2021-7","date_published":"2021-7","updated_at":"2026-07-24T03:55:45Z","subjects":["inflammation","reparative processes","pattern recognition receptors"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:pure.qub.ac.uk/portal:studenttheses/40ce0794-803f-486e-9b86-ecee08dd3dee"],"render_values":[{"text":"oai:pure.qub.ac.uk/portal:studenttheses/40ce0794-803f-486e-9b86-ecee08dd3dee","href":null,"code":true}]}]},"links":{"outbound_url":"https://pure.qub.ac.uk/en/studentTheses/40ce0794-803f-486e-9b86-ecee08dd3dee","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["El Karim, Ikhlas","Dombrowski, Yvonne"]},{"key":"dc:contributor.sponsor","label":"Sponsor","values":["Jordan University of Science and Technology"]},{"key":"dc:creator","label":"Author","values":["Al-Natour, Banan"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2021-7"]},{"key":"dc:date.issued","label":"Date","values":["2021-7"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["School of Medicine, Dentistry and Biomedical Sciences"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["Queen's University Belfast"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://pure.qub.ac.uk/en/studentTheses/40ce0794-803f-486e-9b86-ecee08dd3dee"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["Doctor of Philosophy"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["inflammation","reparative processes","pattern recognition receptors"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights.embargodate","label":"Dc Rights Embargodate","values":["2026-07-31"]},{"key":"dc:rights.embargoreason","label":"Dc Rights Embargoreason","values":["/dk/atira/pure/core/document/studentthesisembargoreason/publicationissues"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:pure.qub.ac.uk/portal:studenttheses/40ce0794-803f-486e-9b86-ecee08dd3dee","https://pure.qub.ac.uk/en/studentTheses/40ce0794-803f-486e-9b86-ecee08dd3dee"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["In the dental pulp, an acute inflammatory response is crucial for initiating healing and repair. The dental pulp is capable of mounting such a response by expressing sophisticated immune response components. Many studies investigated the role of different immune response components in dental pulp inflammation and repair, but the emerging role of Absent in melanoma 2 (AIM2) and Nod-like receptor protein 3 (NLRP3) inflammasomes is yet to be elucidated. <br/><br/>In this thesis, the role of AIM2 and NLPR3 receptors was explored, both in bacterial and sterile inflammation context. Furthermore, the potential of modulating the inflammatory responses via these receptors to mediate repair.<br/><br/>The findings of the thesis confirmed the importance of inflammation in dental pulp healing and repair following injury and demonstrated novel roles for NLRP3 inflammasomes and DNA sensors in this process.<br/><br/><i>Thesis is embargoed until 31 July 2026.</i>"]},{"key":"dc:title","label":"Title","values":["The role of NLRP3 and AIM2 inflammasomes in dental pulp inflammation and reparative processes"]}]}],"canonical_facts":{"dc:contributor.advisor":["El Karim, Ikhlas","Dombrowski, Yvonne"],"dc:contributor.sponsor":["Jordan University of Science and Technology"],"dc:creator":["Al-Natour, Banan"],"dc:date":["2021-7"],"dc:date.issued":["2021-7"],"dc:description.abstract":["In the dental pulp, an acute inflammatory response is crucial for initiating healing and repair. The dental pulp is capable of mounting such a response by expressing sophisticated immune response components. Many studies investigated the role of different immune response components in dental pulp inflammation and repair, but the emerging role of Absent in melanoma 2 (AIM2) and Nod-like receptor protein 3 (NLRP3) inflammasomes is yet to be elucidated. <br/><br/>In this thesis, the role of AIM2 and NLPR3 receptors was explored, both in bacterial and sterile inflammation context. Furthermore, the potential of modulating the inflammatory responses via these receptors to mediate repair.<br/><br/>The findings of the thesis confirmed the importance of inflammation in dental pulp healing and repair following injury and demonstrated novel roles for NLRP3 inflammasomes and DNA sensors in this process.<br/><br/><i>Thesis is embargoed until 31 July 2026.</i>"],"dc:identifier":["oai:pure.qub.ac.uk/portal:studenttheses/40ce0794-803f-486e-9b86-ecee08dd3dee","https://pure.qub.ac.uk/en/studentTheses/40ce0794-803f-486e-9b86-ecee08dd3dee"],"dc:language":["eng"],"dc:publisher.department":["School of Medicine, Dentistry and Biomedical Sciences"],"dc:publisher.institution":["Queen's University Belfast"],"dc:relation.isreferencedby":["https://pure.qub.ac.uk/en/studentTheses/40ce0794-803f-486e-9b86-ecee08dd3dee"],"dc:rights.embargodate":["2026-07-31"],"dc:rights.embargoreason":["/dk/atira/pure/core/document/studentthesisembargoreason/publicationissues"],"dc:subject":["inflammation","reparative processes","pattern recognition receptors"],"dc:title":["The role of NLRP3 and AIM2 inflammasomes in dental pulp inflammation and reparative processes"],"dc:type":["Thesis"],"dc:type.qualificationlevel":["Doctoral Thesis"],"dc:type.qualificationname":["Doctor of Philosophy"]},"updated_at":"2026-07-24T03:55:45Z"}