{"id":{"repo_id":"qu-belfast","oai_identifier":"oai:pure.qub.ac.uk/portal:studenttheses/27e5f359-e464-4a54-a82a-ff9183a5cb34"},"canonical_url":"https://search.dev.ndltd.org/etd/qu-belfast/oai:pure.qub.ac.uk/portal:studenttheses/27e5f359-e464-4a54-a82a-ff9183a5cb34","repository":{"repo_id":"qu-belfast","name":"Queen's University Belfast","base_url":"https://pureadmin.qub.ac.uk/ws/oai"},"display":{"title":"Investigating persistent organic pollutants as endocrine disruptors of androgen receptor signalling","abstract":"Man-made chemicals are a part of everyday life and may mimic hormonal signalling in wildlife and humans. These exogenous mixtures or substances are called endocrine disrupting chemicals and may lead to adverse health effects in those exposed. Persistent organic pollutants (POPs) are a class of organic compounds that are structurally resistant to processes of degradation and thus are ubiquitous in the environment upon release. Due to their long elimination half-lives and affinity for lipid-rich tissue, POPs have a tendency to bioaccumulate, and subsequently have been detected in human tissues such as adipose, breast, placenta and blood. The overall aim of this thesis is to investigate novel human blood-based concentrations of POP mixtures and individual perfluoroalkyl acids (PFAAs) for disrupting androgen receptor (AR) signalling. <br/><br/>The Total POP mixture using in this project consisted of a combination of 29 chemicals modelled on the exposure profile of a Scandinavian population and 6 sub-mixtures: brominated (Br) chlorinated (Cl), Cl + Br, PFAA, PFAA + Br, PFAA + Cl, ranging from 1/10x to 500x relative to what is found in human blood.<br/><br/><br/>","abstract_html":"Man-made chemicals are a part of everyday life and may mimic hormonal signalling in wildlife and humans. These exogenous mixtures or substances are called endocrine disrupting chemicals and may lead to adverse health effects in those exposed. Persistent organic pollutants (POPs) are a class of organic compounds that are structurally resistant to processes of degradation and thus are ubiquitous in the environment upon release. Due to their long elimination half-lives and affinity for lipid-rich tissue, POPs have a tendency to bioaccumulate, and subsequently have been detected in human tissues such as adipose, breast, placenta and blood. The overall aim of this thesis is to investigate novel human blood-based concentrations of POP mixtures and individual perfluoroalkyl acids (PFAAs) for disrupting androgen receptor (AR) signalling. &lt;br/&gt;&lt;br/&gt;The Total POP mixture using in this project consisted of a combination of 29 chemicals modelled on the exposure profile of a Scandinavian population and 6 sub-mixtures: brominated (Br) chlorinated (Cl), Cl + Br, PFAA, PFAA + Br, PFAA + Cl, ranging from 1/10x to 500x relative to what is found in human blood.&lt;br/&gt;&lt;br/&gt;&lt;br/&gt;","abstract_has_math":false,"creators":["McComb, Jonathan"],"institution":"Queen's University Belfast","degree_name":"Doctor of Philosophy","degree_level":"Doctoral Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Connolly, Lisa","Mills, Ian"],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-12","date_published":"2019-12","updated_at":"2026-07-24T03:56:18Z","subjects":["endocrine disrupting chemical","persistent organic pollutant","androgen receptor signalling","reporter gene assay","high content analysis","translocation","mixture","anti-androgen","perfluoroalkly acid","brominated compound","chlorinated compound"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:pure.qub.ac.uk/portal:studenttheses/27e5f359-e464-4a54-a82a-ff9183a5cb34"],"render_values":[{"text":"oai:pure.qub.ac.uk/portal:studenttheses/27e5f359-e464-4a54-a82a-ff9183a5cb34","href":null,"code":true}]}]},"links":{"outbound_url":"https://pure.qub.ac.uk/en/studentTheses/27e5f359-e464-4a54-a82a-ff9183a5cb34","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Connolly, Lisa","Mills, Ian"]},{"key":"dc:creator","label":"Author","values":["McComb, Jonathan"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-12"]},{"key":"dc:date.issued","label":"Date","values":["2019-12"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["School of Biological Sciences"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["Queen's University Belfast"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://pure.qub.ac.uk/en/studentTheses/27e5f359-e464-4a54-a82a-ff9183a5cb34"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["Doctor of Philosophy"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["endocrine disrupting chemical","persistent organic pollutant","androgen receptor signalling","reporter gene assay","high content analysis","translocation","mixture","anti-androgen","perfluoroalkly acid","brominated compound","chlorinated compound"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights.embargodate","label":"Dc Rights Embargodate","values":["2022-12-31"]},{"key":"dc:rights.embargoreason","label":"Dc Rights Embargoreason","values":["/dk/atira/pure/core/document/studentthesisembargoreason/publicationissues"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:pure.qub.ac.uk/portal:studenttheses/27e5f359-e464-4a54-a82a-ff9183a5cb34","https://pure.qub.ac.uk/en/studentTheses/27e5f359-e464-4a54-a82a-ff9183a5cb34"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://pure.qub.ac.uk/files/289720164/Jonathan_McComb_Thesis_CORRECTED_06112019.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Man-made chemicals are a part of everyday life and may mimic hormonal signalling in wildlife and humans. These exogenous mixtures or substances are called endocrine disrupting chemicals and may lead to adverse health effects in those exposed. Persistent organic pollutants (POPs) are a class of organic compounds that are structurally resistant to processes of degradation and thus are ubiquitous in the environment upon release. Due to their long elimination half-lives and affinity for lipid-rich tissue, POPs have a tendency to bioaccumulate, and subsequently have been detected in human tissues such as adipose, breast, placenta and blood. The overall aim of this thesis is to investigate novel human blood-based concentrations of POP mixtures and individual perfluoroalkyl acids (PFAAs) for disrupting androgen receptor (AR) signalling. <br/><br/>The Total POP mixture using in this project consisted of a combination of 29 chemicals modelled on the exposure profile of a Scandinavian population and 6 sub-mixtures: brominated (Br) chlorinated (Cl), Cl + Br, PFAA, PFAA + Br, PFAA + Cl, ranging from 1/10x to 500x relative to what is found in human blood.<br/><br/><br/>"]},{"key":"dc:title","label":"Title","values":["Investigating persistent organic pollutants as endocrine disruptors of androgen receptor signalling"]}]}],"canonical_facts":{"dc:contributor.advisor":["Connolly, Lisa","Mills, Ian"],"dc:creator":["McComb, Jonathan"],"dc:date":["2019-12"],"dc:date.issued":["2019-12"],"dc:description.abstract":["Man-made chemicals are a part of everyday life and may mimic hormonal signalling in wildlife and humans. 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