{"id":{"repo_id":"qu-belfast","oai_identifier":"oai:pure.qub.ac.uk/portal:studenttheses/1bc68383-4848-47f6-b879-c42dc742e60d"},"canonical_url":"https://search.dev.ndltd.org/etd/qu-belfast/oai:pure.qub.ac.uk/portal:studenttheses/1bc68383-4848-47f6-b879-c42dc742e60d","repository":{"repo_id":"qu-belfast","name":"Queen's University Belfast","base_url":"https://pureadmin.qub.ac.uk/ws/oai"},"display":{"title":"Characterisation, bioactivity evaluation and rational modification of bioactive peptides from frog skin secretion and scorpion venom","abstract":"This thesis examines a range of bioactive peptides from the East Asia frog- Pelophylax nigromaculatus, the Chinese bamboo leaf frog - Odorrana versabilis, and the scorpion Androctonus bicolor. In chapter 3 a novel Bowman-Birk type protease inhibitor (ranacyclin-NF) was identified in the skin secretion of Pelophylax nigromaculatus. Besides studying its potential applications, two analogues were designed to study structure-activity relationship of peptide. In Chapter 4, a previously-reported short peptide, Kunitzin-OV, was used as a template to design a set of variants to explore the structure-antimicrobial activity relationship and provide a potent alternative for novel antibiotic agents. In Chapter 5, a deduced venom peptide (AbCCT-1) from the scorpion, Androctonus bicolor, reported in previous literature, was studied. This peptide was used as a template and hybridised with a reported short antimicrobial motif to acquire analogues with antibacterial and anticancer activities. Functional screening and exploration of structure-activity relationship in this work would help in a great understanding of naturally-occurring disulphide-bridged peptides. These bioactive peptides are likely to become potent candidates for novel generation of therapeutic agents in the treatment of several clinic challenges, such as cancer, inflammation, and drug-resistant infections.","abstract_html":"This thesis examines a range of bioactive peptides from the East Asia frog- Pelophylax nigromaculatus, the Chinese bamboo leaf frog - Odorrana versabilis, and the scorpion Androctonus bicolor. In chapter 3 a novel Bowman-Birk type protease inhibitor (ranacyclin-NF) was identified in the skin secretion of Pelophylax nigromaculatus. Besides studying its potential applications, two analogues were designed to study structure-activity relationship of peptide. In Chapter 4, a previously-reported short peptide, Kunitzin-OV, was used as a template to design a set of variants to explore the structure-antimicrobial activity relationship and provide a potent alternative for novel antibiotic agents. In Chapter 5, a deduced venom peptide (AbCCT-1) from the scorpion, Androctonus bicolor, reported in previous literature, was studied. This peptide was used as a template and hybridised with a reported short antimicrobial motif to acquire analogues with antibacterial and anticancer activities. Functional screening and exploration of structure-activity relationship in this work would help in a great understanding of naturally-occurring disulphide-bridged peptides. These bioactive peptides are likely to become potent candidates for novel generation of therapeutic agents in the treatment of several clinic challenges, such as cancer, inflammation, and drug-resistant infections.","abstract_has_math":false,"creators":["Wang, Tao"],"institution":"Queen's University Belfast","degree_name":"Doctor of Philosophy","degree_level":"Doctoral Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Zhou, Mei","Chen, Tianbao","Wang, Lei"],"committee_chairs":[],"committee_members":[],"year":2021,"date_issued":"2021-7","date_published":"2021-7","updated_at":"2026-07-24T03:55:58Z","subjects":["Serine protease inhibitor","Bowman-birk inhibitor","Kunitz inhibitor","antimicrobial peptide","drug-resistance","biofilm","anticancer peptide","anti-inflammation","scorpion venom peptide"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:pure.qub.ac.uk/portal:studenttheses/1bc68383-4848-47f6-b879-c42dc742e60d"],"render_values":[{"text":"oai:pure.qub.ac.uk/portal:studenttheses/1bc68383-4848-47f6-b879-c42dc742e60d","href":null,"code":true}]}]},"links":{"outbound_url":"https://pure.qub.ac.uk/en/studentTheses/1bc68383-4848-47f6-b879-c42dc742e60d","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Zhou, Mei","Chen, Tianbao","Wang, Lei"]},{"key":"dc:creator","label":"Author","values":["Wang, Tao"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2021-7"]},{"key":"dc:date.issued","label":"Date","values":["2021-7"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["School of Pharmacy"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["Queen's University Belfast"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://pure.qub.ac.uk/en/studentTheses/1bc68383-4848-47f6-b879-c42dc742e60d"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["Doctor of Philosophy"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Serine protease inhibitor","Bowman-birk inhibitor","Kunitz inhibitor","antimicrobial peptide","drug-resistance","biofilm","anticancer peptide","anti-inflammation","scorpion venom peptide"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights.embargodate","label":"Dc Rights Embargodate","values":["2026-07-31"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:pure.qub.ac.uk/portal:studenttheses/1bc68383-4848-47f6-b879-c42dc742e60d","https://pure.qub.ac.uk/en/studentTheses/1bc68383-4848-47f6-b879-c42dc742e60d"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["This thesis examines a range of bioactive peptides from the East Asia frog- Pelophylax nigromaculatus, the Chinese bamboo leaf frog - Odorrana versabilis, and the scorpion Androctonus bicolor. In chapter 3 a novel Bowman-Birk type protease inhibitor (ranacyclin-NF) was identified in the skin secretion of Pelophylax nigromaculatus. Besides studying its potential applications, two analogues were designed to study structure-activity relationship of peptide. In Chapter 4, a previously-reported short peptide, Kunitzin-OV, was used as a template to design a set of variants to explore the structure-antimicrobial activity relationship and provide a potent alternative for novel antibiotic agents. In Chapter 5, a deduced venom peptide (AbCCT-1) from the scorpion, Androctonus bicolor, reported in previous literature, was studied. This peptide was used as a template and hybridised with a reported short antimicrobial motif to acquire analogues with antibacterial and anticancer activities. Functional screening and exploration of structure-activity relationship in this work would help in a great understanding of naturally-occurring disulphide-bridged peptides. These bioactive peptides are likely to become potent candidates for novel generation of therapeutic agents in the treatment of several clinic challenges, such as cancer, inflammation, and drug-resistant infections."]},{"key":"dc:title","label":"Title","values":["Characterisation, bioactivity evaluation and rational modification of bioactive peptides from frog skin secretion and scorpion venom"]}]}],"canonical_facts":{"dc:contributor.advisor":["Zhou, Mei","Chen, Tianbao","Wang, Lei"],"dc:creator":["Wang, Tao"],"dc:date":["2021-7"],"dc:date.issued":["2021-7"],"dc:description.abstract":["This thesis examines a range of bioactive peptides from the East Asia frog- Pelophylax nigromaculatus, the Chinese bamboo leaf frog - Odorrana versabilis, and the scorpion Androctonus bicolor. In chapter 3 a novel Bowman-Birk type protease inhibitor (ranacyclin-NF) was identified in the skin secretion of Pelophylax nigromaculatus. Besides studying its potential applications, two analogues were designed to study structure-activity relationship of peptide. In Chapter 4, a previously-reported short peptide, Kunitzin-OV, was used as a template to design a set of variants to explore the structure-antimicrobial activity relationship and provide a potent alternative for novel antibiotic agents. In Chapter 5, a deduced venom peptide (AbCCT-1) from the scorpion, Androctonus bicolor, reported in previous literature, was studied. This peptide was used as a template and hybridised with a reported short antimicrobial motif to acquire analogues with antibacterial and anticancer activities. Functional screening and exploration of structure-activity relationship in this work would help in a great understanding of naturally-occurring disulphide-bridged peptides. 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