NANOPARTICLE DEPOT FOR INTRAPERITONEAL CHEMOTHERAPY OF OVARIAN CANCER

Intraperitoneal (IP) chemotherapy is a promising post-surgical therapy of ovarian cancer, with the full potential yet to be proven. To facilitate IP chemotherapy of ovarian cancer, we have developed a nanoparticle depot for IP chemotherapy consisted of paclitaxel (PTX) nanocrystals (PNC) and hyaluronic acid-based hydrogel (HA gel). PNC with a size of ~310 nm was produced by nonsolvent and temperature-induced crystallization. Dissolution kinetics of PNC could be determined by the light scattering method rather than the dialysis method due to drug reprecipitation caused by diffusion barrier. PTX release profiles from PNC-gel and PTX precipitate-gel (PPT-gel) were estimated in both sink- and non-sink conditions, where the latter simulated the peritoneal environment. In-vitro release kinetics studies did not reveal any difference between PNC-gel and PPT-gel, partly due to the centrifugation-related artifacts.

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Industrial and Physical Pharmacy

Year

2016

Author dc:creator

• Sun, Bo

Contributors dc:contributor

• Yoon Yeo
• Tonglei Li
• Rodolfo Pinal
• Kinam Park

Repository record dc:identifier

https://docs.lib.purdue.edu/open_access_dissertations/1480

OAI identifier oai:identifier

oai:docs.lib.purdue.edu:open_access_dissertations-2696