Abstract
dc:description.abstractMost drug substances are reported to be either weak acids or weak bases. Hence, acid-base reactions are commonly observed in pharmaceutical systems with samples including salts, amorphous solid dispersions, and in formulated products. Salt formation of active pharmaceutical ingredients (APIs) is widely recognized as one of the most commonly used approaches to modify the solubility and dissolution rate. Formulating poorly water-soluble weak acids or weak bases into salts can not only increase bioavailability, but also improve the stability and manufacturability of APIs by changing their solid-state properties. However, from a formulation perspective, acid-base reactions might occur between APIs and ionizable excipients, which would induce deleterious form conversions or chemical degradation of the APIs during storage or manufacturing. Therefore, understanding the fundamentals of acid-base reactions is critical to design a robust formulation and to avoid drug-excipients incompatibility issues in multicomponent pharmaceutical products.
Degree
thesis:*- Name thesis:degree_name
- Doctor of Philosophy (PhD)
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Industrial and Physical Pharmacy
- Year
- 2016
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Nie, Haichen
- Contributors dc:contributor
-
- Stephen R. Byrn
- Lynne S. Taylor
- Rodolfo Pinal
- Gregory T. Knipp
- Patrick J. Marsac
Subjects
dc:subject × 5Identifiers
dc:identifier.*- Repository record dc:identifier
- https://docs.lib.purdue.edu/open_access_dissertations/1295
- OAI identifier oai:identifier
- oai:docs.lib.purdue.edu:open_access_dissertations-2511