{"id":{"repo_id":"purdue-thes","oai_identifier":"oai:docs.lib.purdue.edu:open_access_dissertations-2443"},"canonical_url":"https://search.dev.ndltd.org/etd/purdue-thes/oai:docs.lib.purdue.edu:open_access_dissertations-2443","repository":{"repo_id":"purdue-thes","name":"Purdue University","base_url":"https://docs.lib.purdue.edu/do/oai/"},"display":{"title":"REGULATION OF T CELLS AND TISSUE INFLAMMATION BY SHORT CHAIN FATTY ACIDS","abstract":"Intestinal microbiota regulate various biological processes in the host. Intestinal microbiota produce short chain fatty acids (SCFAs) via dietary fiber fermentation. SCFAs have profound effects on the immune system. We investigated the roles of SCFAs in regulating T cell differentiation and tissue inflammation. We found that SCFAs regulate T cell differentiation and T cell-mediated immunity. SCFAs enhanced both IL-10+ T cell and Th1/Th17 effector T cell differentiation. SCFAs inhibited histone deacetylase (HDAC) activity and upregulated acetylation of p70 S6 kinase and mTOR activation in T cells. We also found that prolonged exposure to high concentration of SCFA cause ureteral obstruction and hydronephrosis. SCFAs activated mTOR signaling in renal T cells and developed T cell-mediated inflammation in the ureter and kidneys. In sum, SCFAs promote immunity but can also regulate inflammatory diseases.","abstract_html":"Intestinal microbiota regulate various biological processes in the host. Intestinal microbiota produce short chain fatty acids (SCFAs) via dietary fiber fermentation. SCFAs have profound effects on the immune system. We investigated the roles of SCFAs in regulating T cell differentiation and tissue inflammation. We found that SCFAs regulate T cell differentiation and T cell-mediated immunity. SCFAs enhanced both IL-10+ T cell and Th1/Th17 effector T cell differentiation. SCFAs inhibited histone deacetylase (HDAC) activity and upregulated acetylation of p70 S6 kinase and mTOR activation in T cells. We also found that prolonged exposure to high concentration of SCFA cause ureteral obstruction and hydronephrosis. SCFAs activated mTOR signaling in renal T cells and developed T cell-mediated inflammation in the ureter and kidneys. In sum, SCFAs promote immunity but can also regulate inflammatory diseases.","abstract_has_math":false,"creators":["Park, Jeong Ho"],"institution":null,"degree_name":"Doctor of Philosophy (PhD)","degree_level":"Dissertation","degree_discipline":"Comparative Pathobiology","degree_department":null,"school":null,"contributors":["Chang Kim","Yava L Jones","Harm Hogenesch","John A Patterson"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016-01-01T08:00:00Z","date_published":"2016-01-01T08:00:00Z","updated_at":"2026-07-24T03:54:31Z","subjects":[],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://docs.lib.purdue.edu/open_access_dissertations/1227","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Chang Kim","Yava L Jones","Harm Hogenesch","John A Patterson"]},{"key":"dc:creator","label":"Author","values":["Park, Jeong Ho"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Comparative Pathobiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (PhD)"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://docs.lib.purdue.edu/open_access_dissertations/1227"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Intestinal microbiota regulate various biological processes in the host. Intestinal microbiota produce short chain fatty acids (SCFAs) via dietary fiber fermentation. SCFAs have profound effects on the immune system. We investigated the roles of SCFAs in regulating T cell differentiation and tissue inflammation. We found that SCFAs regulate T cell differentiation and T cell-mediated immunity. SCFAs enhanced both IL-10+ T cell and Th1/Th17 effector T cell differentiation. SCFAs inhibited histone deacetylase (HDAC) activity and upregulated acetylation of p70 S6 kinase and mTOR activation in T cells. We also found that prolonged exposure to high concentration of SCFA cause ureteral obstruction and hydronephrosis. SCFAs activated mTOR signaling in renal T cells and developed T cell-mediated inflammation in the ureter and kidneys. In sum, SCFAs promote immunity but can also regulate inflammatory diseases."]},{"key":"dc:title","label":"Title","values":["REGULATION OF T CELLS AND TISSUE INFLAMMATION BY SHORT CHAIN FATTY ACIDS"]}]}],"canonical_facts":{"dc:contributor":["Chang Kim","Yava L Jones","Harm Hogenesch","John A Patterson"],"dc:creator":["Park, Jeong Ho"],"dc:description.abstract":["Intestinal microbiota regulate various biological processes in the host. Intestinal microbiota produce short chain fatty acids (SCFAs) via dietary fiber fermentation. SCFAs have profound effects on the immune system. We investigated the roles of SCFAs in regulating T cell differentiation and tissue inflammation. We found that SCFAs regulate T cell differentiation and T cell-mediated immunity. SCFAs enhanced both IL-10+ T cell and Th1/Th17 effector T cell differentiation. SCFAs inhibited histone deacetylase (HDAC) activity and upregulated acetylation of p70 S6 kinase and mTOR activation in T cells. We also found that prolonged exposure to high concentration of SCFA cause ureteral obstruction and hydronephrosis. SCFAs activated mTOR signaling in renal T cells and developed T cell-mediated inflammation in the ureter and kidneys. In sum, SCFAs promote immunity but can also regulate inflammatory diseases."],"dc:identifier":["https://docs.lib.purdue.edu/open_access_dissertations/1227"],"dc:title":["REGULATION OF T CELLS AND TISSUE INFLAMMATION BY SHORT CHAIN FATTY ACIDS"],"thesis:degree_discipline":["Comparative Pathobiology"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Doctor of Philosophy (PhD)"]},"updated_at":"2026-07-24T03:54:31Z"}