Physikalische Hydrogele auf Polyurethan-Basis

Physical hydrogels have gained recent attention as cell substrates, since viscoelasticity or stress relaxation is a powerful parameter in mechanotransduction, which has long been neglected. We designed multi-functional polyurethanes to form physical hydrogels via a unique tunable gelation mechanism. The anionic polyurethanes spontaneously form aggregates in water that are kept in a soluble state through electrostatic repulsion. Fast subsequent gelation can be triggered by charge shielding which allows the aggregation and network building to proceed. This can be induced by adding either acids or salts, resulting in acidic (pH 4-5) or pH-neutral hydrogels, respectively. Whereas conventional polyurethane-based hydrogels are commonly prepared from toxic isocyanate precursors, the physical hydrogelation mechanism described here does not involve chemically reactive species which is ideal for in situ applications in sensitive environments. Both stiffness and stress relaxation can be tuned independently over a broad range and the gels exhibit excellent stress recovery behavior.

Level thesis:degree_level

thesis.doctoral

Grantor dc:publisher

Universität Potsdam

Year

2016

Author dc:creator

• Leiendecker, Mai-Thi

Contributors dc:contributor

• Böker, Alexander

• Polyurethane
• Hydrogele
• physikalische Hydrogele
• Kolloidchemie
• Viskoelastizität
• Stressrelaxation
• Stressrelaxierung
• Bulkgele
• Mikrogele
• Mechanotransduktion
• polyurethanes
• hydrogels
• physical hydrogels
• colloidal chemistry
• viscoelasticity
• stress-relaxation
• stress relaxation
• bulk gels
• microgels
• mechanotransduction

Statement dc:rights

• Keine öffentliche Lizenz: Unter Urheberrechtsschutz

Repository record source_url

https://publishup.uni-potsdam.de/frontdoor/index/index/docId/10391

OAI identifier oai:identifier

oai:kobv.de-opus4-uni-potsdam:10391