CHITOSAN PARTICLES FOR THE CONTROLLED RELEASE OF PROTEINS
type: CreativeWork
description: Back Ground Chitosan as a natural polymer has been fabulated into a number of formulations such as films, hydrogels and particles based on its excellent properties such as biodegradable, biocompotable, bioadhesive, permeartion-enhancement, antibiotic, antitumor etc. properties. Among them, chitosan microparticles found a lot of applications in pharmaceutics such as vaccine delivery, mucosal delivery and gene delivery, etc. Down to the nanoscale, chitosan nanoparticles have more attractive properties more than that of chitosan microparticles, which further widen the applications of chitosan particles in biomedicine and biopharmaceutics. Objective of this Thesis This thesis is aimed to prepare chitosan micro or nanoparticles to delivery proteins. What are the questions this thesis attempted to solve? 1) What are the proper preparation conditions of chitosan micro or nanoparticles? 2) How does the pH value affect the formation and protein encapsulation of chitosan nanoparticles? 3) How to overcome the burst release of chitosan nanoparticles? 4) How to overcome the aggregation disadvantage in the contritional preparation process of TPP-gelated chitosan microparticles? 5) How to construct a composite particles system to realize the sustainable release of proteins? What are the methods used in this thesis? 1) ionotropic gelation method to prepare chitosan nanoparticles 2) Emulsification-coacervation (NaOH) method to prepare chitosan microparticles 3) a polyelectrolytes coacervation method to prepare chitosan-BSA complexes 4) a microemulsion involved emulsification-coalescence method to prepare TPP-gelated chitosan microparticles 5) a nanoparticles encapsulation method to prepare composite particles. Results and Conclutions 1) the effect of preparation parameters on the properties of chitosan nanoparticles: 1a) the concentration of chitosan has no siganificant effect on particles yield, positively associated with particles size, size distribution, positively associated wit…
abstract: Back Ground Chitosan as a natural polymer has been fabulated into a number of formulations such as films, hydrogels and particles based on its excellent properties such as biodegradable, biocompotable, bioadhesive, permeartion-enhancement, antibiotic, antitumor etc. properties. Among them, chitosan microparticles found a lot of applications in pharmaceutics such as vaccine delivery, mucosal delivery and gene delivery, etc. Down to the nanoscale, chitosan nanoparticles have more attractive properties more than that of chitosan microparticles, which further widen the applications of chitosan particles in biomedicine and biopharmaceutics. Objective of this Thesis This thesis is aimed to prepare chitosan micro or nanoparticles to delivery proteins. What are the questions this thesis attempted to solve? 1) What are the proper preparation conditions of chitosan micro or nanoparticles? 2) How does the pH value affect the formation and protein encapsulation of chitosan nanoparticles? 3) How to overcome the burst release of chitosan nanoparticles? 4) How to overcome the aggregation disadvantage in the contritional preparation process of TPP-gelated chitosan microparticles? 5) How to construct a composite particles system to realize the sustainable release of proteins? What are the methods used in this thesis? 1) ionotropic gelation method to prepare chitosan nanoparticles 2) Emulsification-coacervation (NaOH) method to prepare chitosan microparticles 3) a polyelectrolytes coacervation method to prepare chitosan-BSA complexes 4) a microemulsion involved emulsification-coalescence method to prepare TPP-gelated chitosan microparticles 5) a nanoparticles encapsulation method to prepare composite particles. Results and Conclutions 1) the effect of preparation parameters on the properties of chitosan nanoparticles: 1a) the concentration of chitosan has no siganificant effect on particles yield, positively associated with particles size, size distribution, positively associated wit…
author: LI, RUO
language: eng
keywords: chitosan nanoparticle, protein, controlled release, Settore ING-IND/34 - Bioingegneria Industriale
date published: 2012
date modified: 2026-07-24T03:51:03Z
provider: Politecnico di Torino
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Politecnico di Torino

PropertyValue
property ID: Handle
value: http://hdl.handle.net/11583/2497932

PropertyValue
property ID: DOI
value: 10.6092/polito/porto/2497932