{"id":{"repo_id":"penn","oai_identifier":"oai:repository.upenn.edu:20.500.14332/62624"},"canonical_url":"https://search.dev.ndltd.org/etd/penn/oai:repository.upenn.edu:20.500.14332/62624","repository":{"repo_id":"penn","name":"University of Pennsylvania","base_url":"https://repository.upenn.edu/server/oai/request"},"display":{"title":"Peri-Radicular Healing Following Endodontic Microsurgery Grafted with Leukocyte and Platelet Rich Fibrin (L-PRF): One Year Evaluation with Cone Beam Computed Tomography","abstract":"Introduction: This observational retrospective study evaluated periradicular healing following endodontic microsurgery grafted with leukocyte and platelet-rich fibrin (L-PRF) using 2D periapical radiographs and 3D cone-beam computed tomography (CBCT). Methods: Seventy patients (77 surgical sites) were enrolled, of whom 51 cases met the inclusion criteria for analysis and comparison with a historical clinical standard group. Healing outcomes were assessed at one year using Molven’s 2D and PENN 3D criteria. Results: Complete cortical plate regeneration (C-score = 2) occurred in 58.1% of L-PRF cases versus 50% in the clinical standard group, although the differences were not statistically significant (OR 1.38; 95% CI: 0.49–4.00). The complete healing rates on 2D radiographs were 61.3% for L-PRF and 80.7% for the clinical standard; on CBCT, complete healing was 58.1% for L-PRF and 46.2% for the clinical standard, with no significant differences between groups. Adequate root-end filling significantly increased the odds of 2D complete healing (OR 6.91; p=0.0136). The overall success rates, including clinical symptoms, were 68.6% (2D) and 80% (3D) for L-PRF, comparable to controls. A pre-operative cortical plate thickness >0.5 mm was associated with improved cortical regeneration. Conclusion: The findings suggest that L-PRF may modestly enhance cortical bone healing after endodontic microsurgery, but the difference was not statistically significant. Given the autologous nature and biological properties of L-PRF, further randomized controlled trials with larger sample sizes and longer follow-up periods are warranted to clarify its clinical benefits, especially in complex lesions.","abstract_html":"Introduction: This observational retrospective study evaluated periradicular healing following endodontic microsurgery grafted with leukocyte and platelet-rich fibrin (L-PRF) using 2D periapical radiographs and 3D cone-beam computed tomography (CBCT). Methods: Seventy patients (77 surgical sites) were enrolled, of whom 51 cases met the inclusion criteria for analysis and comparison with a historical clinical standard group. Healing outcomes were assessed at one year using Molven’s 2D and PENN 3D criteria. Results: Complete cortical plate regeneration (C-score = 2) occurred in 58.1% of L-PRF cases versus 50% in the clinical standard group, although the differences were not statistically significant (OR 1.38; 95% CI: 0.49–4.00). The complete healing rates on 2D radiographs were 61.3% for L-PRF and 80.7% for the clinical standard; on CBCT, complete healing was 58.1% for L-PRF and 46.2% for the clinical standard, with no significant differences between groups. Adequate root-end filling significantly increased the odds of 2D complete healing (OR 6.91; p=0.0136). The overall success rates, including clinical symptoms, were 68.6% (2D) and 80% (3D) for L-PRF, comparable to controls. A pre-operative cortical plate thickness >0.5 mm was associated with improved cortical regeneration. Conclusion: The findings suggest that L-PRF may modestly enhance cortical bone healing after endodontic microsurgery, but the difference was not statistically significant. Given the autologous nature and biological properties of L-PRF, further randomized controlled trials with larger sample sizes and longer follow-up periods are warranted to clarify its clinical benefits, especially in complex lesions.","abstract_has_math":false,"creators":["Grinsell, Andrew"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Karabucak, Bekir"],"committee_chairs":[],"committee_members":[],"year":2026,"date_issued":"2026-05-18","date_published":"2026-05-18","updated_at":"2026-07-24T03:47:17Z","subjects":["Dentistry"],"languages":["en"],"rights":[],"rights_urls":["https://creativecommons.org/licenses/by/4.0/"],"identifier_entries":[]},"links":{"outbound_url":"https://repository.upenn.edu/handle/20.500.14332/62624","outbound_label":"Repository record","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Karabucak, Bekir"]},{"key":"dc:creator","label":"Author","values":["Grinsell, Andrew"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2026-05-20T20:00:40Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2026-05-20T20:00:40Z"]},{"key":"dc:date.issued","label":"Date","values":["2026-05-18"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation/Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Dentistry"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]},{"key":"dc:rights.uri","label":"Rights URI","values":["https://creativecommons.org/licenses/by/4.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://repository.upenn.edu/handle/20.500.14332/62624"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Introduction: This observational retrospective study evaluated periradicular healing following endodontic microsurgery grafted with leukocyte and platelet-rich fibrin (L-PRF) using 2D periapical radiographs and 3D cone-beam computed tomography (CBCT). Methods: Seventy patients (77 surgical sites) were enrolled, of whom 51 cases met the inclusion criteria for analysis and comparison with a historical clinical standard group. Healing outcomes were assessed at one year using Molven’s 2D and PENN 3D criteria. Results: Complete cortical plate regeneration (C-score = 2) occurred in 58.1% of L-PRF cases versus 50% in the clinical standard group, although the differences were not statistically significant (OR 1.38; 95% CI: 0.49–4.00). The complete healing rates on 2D radiographs were 61.3% for L-PRF and 80.7% for the clinical standard; on CBCT, complete healing was 58.1% for L-PRF and 46.2% for the clinical standard, with no significant differences between groups. Adequate root-end filling significantly increased the odds of 2D complete healing (OR 6.91; p=0.0136). The overall success rates, including clinical symptoms, were 68.6% (2D) and 80% (3D) for L-PRF, comparable to controls. A pre-operative cortical plate thickness >0.5 mm was associated with improved cortical regeneration. Conclusion: The findings suggest that L-PRF may modestly enhance cortical bone healing after endodontic microsurgery, but the difference was not statistically significant. Given the autologous nature and biological properties of L-PRF, further randomized controlled trials with larger sample sizes and longer follow-up periods are warranted to clarify its clinical benefits, especially in complex lesions."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["Master of Science in Oral Biology"]},{"key":"dc:title","label":"Title","values":["Peri-Radicular Healing Following Endodontic Microsurgery Grafted with Leukocyte and Platelet Rich Fibrin (L-PRF): One Year Evaluation with Cone Beam Computed Tomography"]}]}],"canonical_facts":{"dc:contributor.advisor":["Karabucak, Bekir"],"dc:creator":["Grinsell, Andrew"],"dc:date.accessioned":["2026-05-20T20:00:40Z"],"dc:date.available":["2026-05-20T20:00:40Z"],"dc:date.issued":["2026-05-18"],"dc:description.abstract":["Introduction: This observational retrospective study evaluated periradicular healing following endodontic microsurgery grafted with leukocyte and platelet-rich fibrin (L-PRF) using 2D periapical radiographs and 3D cone-beam computed tomography (CBCT). Methods: Seventy patients (77 surgical sites) were enrolled, of whom 51 cases met the inclusion criteria for analysis and comparison with a historical clinical standard group. Healing outcomes were assessed at one year using Molven’s 2D and PENN 3D criteria. Results: Complete cortical plate regeneration (C-score = 2) occurred in 58.1% of L-PRF cases versus 50% in the clinical standard group, although the differences were not statistically significant (OR 1.38; 95% CI: 0.49–4.00). The complete healing rates on 2D radiographs were 61.3% for L-PRF and 80.7% for the clinical standard; on CBCT, complete healing was 58.1% for L-PRF and 46.2% for the clinical standard, with no significant differences between groups. Adequate root-end filling significantly increased the odds of 2D complete healing (OR 6.91; p=0.0136). The overall success rates, including clinical symptoms, were 68.6% (2D) and 80% (3D) for L-PRF, comparable to controls. A pre-operative cortical plate thickness >0.5 mm was associated with improved cortical regeneration. Conclusion: The findings suggest that L-PRF may modestly enhance cortical bone healing after endodontic microsurgery, but the difference was not statistically significant. Given the autologous nature and biological properties of L-PRF, further randomized controlled trials with larger sample sizes and longer follow-up periods are warranted to clarify its clinical benefits, especially in complex lesions."],"dc:description.degree":["Master of Science in Oral Biology"],"dc:identifier.uri":["https://repository.upenn.edu/handle/20.500.14332/62624"],"dc:language.iso":["en"],"dc:rights.uri":["https://creativecommons.org/licenses/by/4.0/"],"dc:subject":["Dentistry"],"dc:title":["Peri-Radicular Healing Following Endodontic Microsurgery Grafted with Leukocyte and Platelet Rich Fibrin (L-PRF): One Year Evaluation with Cone Beam Computed Tomography"],"dc:type":["Dissertation/Thesis"]},"updated_at":"2026-07-24T03:47:17Z"}