{"id":{"repo_id":"patras-thes","oai_identifier":"oai:nemertes.library.upatras.gr:10889/12114"},"canonical_url":"https://search.dev.ndltd.org/etd/patras-thes/oai:nemertes.library.upatras.gr:10889/12114","repository":{"repo_id":"patras-thes","name":"University of Patras","base_url":"http://nemertes.lis.upatras.gr/server/oai/request"},"display":{"title":"Patients with adrenal adenomas and autonomous cortisol secretion. Impact of hypercortisolism on skeletal and adipose tissue mass, measured in abdominal computed tomography","abstract":"Context: Abdominal visceral adiposity and central sarcopenia are markers of increased cardiovascular risk and mortality. Objective: To assess whether central sarcopenia and adiposity can serve as a marker of disease severity in patients with adrenal adenomas and glucocorticoid secretory autonomy. Design: Retrospective cohort study Patients: Twenty-five patients with overt Cushing syndrome (CS), 48 patients with mild autonomous cortisol excess (MACE), and 32 patients with a non-functioning adrenal tumor (NFAT) were included. Methods: Medical records were reviewed and body composition measurements (visceral fat [VAT], subcutaneous fat [SAT], visceral/total fat [V/T], visceral/subcutaneous [V/S] and total abdominal muscle mass) were calculated based on abdominal computed tomography (CT). Results: In patients with overt CS, when compared to patients with NFAT, the V/T fat and the V/S ratio were increased by 0.08 (P<0.001) and by 0.3 (P<0.001); however, these measurements were decreased by 0.04 (P=0.007) and 0.2 (P=0.01), respectively in patients with MACE. Total muscle mass was decreased by -10 cm2 (P =0.02) in patients with overt CS compared to patients with NFAT.Correlation with morning serum cortisol concentrations after dexamethasone suppression testing revealed that for every 28nmol/L cortisol increase there was a 0.008 increase in V/T (P<0.001), 0.02 increase in the V/S fat ratio (P<0.001), and a 1.2 cm2 decrease in mean total muscle mass (P=0.002). Conclusions: The severity of hypercortisolism was correlated with lower muscle mass and higher visceral adiposity. These CT-based markers may allow for a more reliable and objective assessment of glucocorticoid-related disease severity in patients with adrenal adenomas.","abstract_html":"Context: Abdominal visceral adiposity and central sarcopenia are markers of increased cardiovascular risk and mortality. Objective: To assess whether central sarcopenia and adiposity can serve as a marker of disease severity in patients with adrenal adenomas and glucocorticoid secretory autonomy. Design: Retrospective cohort study Patients: Twenty-five patients with overt Cushing syndrome (CS), 48 patients with mild autonomous cortisol excess (MACE), and 32 patients with a non-functioning adrenal tumor (NFAT) were included. Methods: Medical records were reviewed and body composition measurements (visceral fat [VAT], subcutaneous fat [SAT], visceral/total fat [V/T], visceral/subcutaneous [V/S] and total abdominal muscle mass) were calculated based on abdominal computed tomography (CT). Results: In patients with overt CS, when compared to patients with NFAT, the V/T fat and the V/S ratio were increased by 0.08 (P&lt;0.001) and by 0.3 (P&lt;0.001); however, these measurements were decreased by 0.04 (P=0.007) and 0.2 (P=0.01), respectively in patients with MACE. Total muscle mass was decreased by -10 cm2 (P =0.02) in patients with overt CS compared to patients with NFAT.Correlation with morning serum cortisol concentrations after dexamethasone suppression testing revealed that for every 28nmol/L cortisol increase there was a 0.008 increase in V/T (P&lt;0.001), 0.02 increase in the V/S fat ratio (P&lt;0.001), and a 1.2 cm2 decrease in mean total muscle mass (P=0.002). Conclusions: The severity of hypercortisolism was correlated with lower muscle mass and higher visceral adiposity. These CT-based markers may allow for a more reliable and objective assessment of glucocorticoid-related disease severity in patients with adrenal adenomas.","abstract_has_math":false,"creators":["Δεληβάνη, Δανάη"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Κυριαζοπούλου, Βενετσάνα","Delivani, Danae","Γώγος, Χαράλαμπος","Bancos, Irina","Χαμπαίος, Ιωάννης","Ακινοσόγλου, Καρολίνα-Ανθούλα","Ζαμπάκης, Πέτρος","Καλογεροπούλου, Χριστίνα"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-05-05T16:43:00Z","date_published":"2019-05-05T16:43:00Z","updated_at":"2026-07-27T20:29:32Z","subjects":["Hypercortisolemia","Adrenal adenomas","Adipose tissue","Muscle mass","Υπερκορτιζολαιμία","Αδένωμα επινεφριδίων","Λιπώδης ιστός","Μυικός ιστός"],"languages":["en_US"],"rights":["0"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10889/12114","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Κυριαζοπούλου, Βενετσάνα","Delivani, Danae","Γώγος, Χαράλαμπος","Bancos, Irina","Χαμπαίος, Ιωάννης","Ακινοσόγλου, Καρολίνα-Ανθούλα","Ζαμπάκης, Πέτρος","Καλογεροπούλου, Χριστίνα"]},{"key":"dc:creator","label":"Author","values":["Δεληβάνη, Δανάη"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-05-05T16:43:00Z","2018-07"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Hypercortisolemia","Adrenal adenomas","Adipose tissue","Muscle mass","Υπερκορτιζολαιμία","Αδένωμα επινεφριδίων","Λιπώδης ιστός","Μυικός ιστός"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en_US"]},{"key":"dc:rights","label":"Dc Rights","values":["0"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10889/12114"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Context: Abdominal visceral adiposity and central sarcopenia are markers of increased cardiovascular risk and mortality. Objective: To assess whether central sarcopenia and adiposity can serve as a marker of disease severity in patients with adrenal adenomas and glucocorticoid secretory autonomy. Design: Retrospective cohort study Patients: Twenty-five patients with overt Cushing syndrome (CS), 48 patients with mild autonomous cortisol excess (MACE), and 32 patients with a non-functioning adrenal tumor (NFAT) were included. Methods: Medical records were reviewed and body composition measurements (visceral fat [VAT], subcutaneous fat [SAT], visceral/total fat [V/T], visceral/subcutaneous [V/S] and total abdominal muscle mass) were calculated based on abdominal computed tomography (CT). Results: In patients with overt CS, when compared to patients with NFAT, the V/T fat and the V/S ratio were increased by 0.08 (P<0.001) and by 0.3 (P<0.001); however, these measurements were decreased by 0.04 (P=0.007) and 0.2 (P=0.01), respectively in patients with MACE. Total muscle mass was decreased by -10 cm2 (P =0.02) in patients with overt CS compared to patients with NFAT.Correlation with morning serum cortisol concentrations after dexamethasone suppression testing revealed that for every 28nmol/L cortisol increase there was a 0.008 increase in V/T (P<0.001), 0.02 increase in the V/S fat ratio (P<0.001), and a 1.2 cm2 decrease in mean total muscle mass (P=0.002). Conclusions: The severity of hypercortisolism was correlated with lower muscle mass and higher visceral adiposity. These CT-based markers may allow for a more reliable and objective assessment of glucocorticoid-related disease severity in patients with adrenal adenomas.","Κεντρική παχυσαρκία και σαρκοπενία είναι δυο δείκτες ένδειξης αυξημένου καρδιαγγειακου κινδύνου. Σκοπός της εργασιας αυτης ειναι να μελετησουμε αν οι μετρήσεις μυικής μαζας και λιπώδους ιστού μπορουν να χρησιμοποιηθούν ως δείκτες αυξημενου καρδιαγγειακου κινδύνου σε ασθενείς με αδενώματα των επινεφριδιων και αυτόνομη εκκριση κορτιζολης."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Patients with adrenal adenomas and autonomous cortisol secretion. Impact of hypercortisolism on skeletal and adipose tissue mass, measured in abdominal computed tomography","Ασθενείς με αδένωμα επινεφριδίου και αυτόνομη έκκριση κορτιζόλης. Μελέτη του μυ και λιπώδους ιστού με αξονική τομογραφία και συσχέτιση των ευρημάτων με την αυτόνομη υπερκορτιζολαιμία και συνοδά νοσήματα"]}]}],"canonical_facts":{"dc:contributor":["Κυριαζοπούλου, Βενετσάνα","Delivani, Danae","Γώγος, Χαράλαμπος","Bancos, Irina","Χαμπαίος, Ιωάννης","Ακινοσόγλου, Καρολίνα-Ανθούλα","Ζαμπάκης, Πέτρος","Καλογεροπούλου, Χριστίνα"],"dc:creator":["Δεληβάνη, Δανάη"],"dc:date":["2019-05-05T16:43:00Z","2018-07"],"dc:description":["Context: Abdominal visceral adiposity and central sarcopenia are markers of increased cardiovascular risk and mortality. Objective: To assess whether central sarcopenia and adiposity can serve as a marker of disease severity in patients with adrenal adenomas and glucocorticoid secretory autonomy. Design: Retrospective cohort study Patients: Twenty-five patients with overt Cushing syndrome (CS), 48 patients with mild autonomous cortisol excess (MACE), and 32 patients with a non-functioning adrenal tumor (NFAT) were included. Methods: Medical records were reviewed and body composition measurements (visceral fat [VAT], subcutaneous fat [SAT], visceral/total fat [V/T], visceral/subcutaneous [V/S] and total abdominal muscle mass) were calculated based on abdominal computed tomography (CT). Results: In patients with overt CS, when compared to patients with NFAT, the V/T fat and the V/S ratio were increased by 0.08 (P<0.001) and by 0.3 (P<0.001); however, these measurements were decreased by 0.04 (P=0.007) and 0.2 (P=0.01), respectively in patients with MACE. Total muscle mass was decreased by -10 cm2 (P =0.02) in patients with overt CS compared to patients with NFAT.Correlation with morning serum cortisol concentrations after dexamethasone suppression testing revealed that for every 28nmol/L cortisol increase there was a 0.008 increase in V/T (P<0.001), 0.02 increase in the V/S fat ratio (P<0.001), and a 1.2 cm2 decrease in mean total muscle mass (P=0.002). Conclusions: The severity of hypercortisolism was correlated with lower muscle mass and higher visceral adiposity. These CT-based markers may allow for a more reliable and objective assessment of glucocorticoid-related disease severity in patients with adrenal adenomas.","Κεντρική παχυσαρκία και σαρκοπενία είναι δυο δείκτες ένδειξης αυξημένου καρδιαγγειακου κινδύνου. Σκοπός της εργασιας αυτης ειναι να μελετησουμε αν οι μετρήσεις μυικής μαζας και λιπώδους ιστού μπορουν να χρησιμοποιηθούν ως δείκτες αυξημενου καρδιαγγειακου κινδύνου σε ασθενείς με αδενώματα των επινεφριδιων και αυτόνομη εκκριση κορτιζολης."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10889/12114"],"dc:language":["en_US"],"dc:rights":["0"],"dc:subject":["Hypercortisolemia","Adrenal adenomas","Adipose tissue","Muscle mass","Υπερκορτιζολαιμία","Αδένωμα επινεφριδίων","Λιπώδης ιστός","Μυικός ιστός"],"dc:title":["Patients with adrenal adenomas and autonomous cortisol secretion. Impact of hypercortisolism on skeletal and adipose tissue mass, measured in abdominal computed tomography","Ασθενείς με αδένωμα επινεφριδίου και αυτόνομη έκκριση κορτιζόλης. Μελέτη του μυ και λιπώδους ιστού με αξονική τομογραφία και συσχέτιση των ευρημάτων με την αυτόνομη υπερκορτιζολαιμία και συνοδά νοσήματα"],"dc:type":["Thesis"]},"updated_at":"2026-07-27T20:29:32Z"}