https://search.dev.ndltd.org/etd/patras-thes/oai:nemertes.library.upatras.gr:10889/10617
type: CreativeWork
name: Neuropsychological functions and association with single photon emission computed tomography (SPECT) in Greek multiple sclerosis patients : efficacy of a computerized cognitive rehabilitation intervention
description: While the prevalence and pattern of cognitive dysfunction in multiple sclerosis (MS) is well documented, cognitive deterioration remains one of the most disabling characteristics of MS, and among the most difficult symptoms to manage. The impact of cognitive dysfunction in this population is significant with negative consequences on activities of daily living, loss of employment and ultimately quality of life. Past and current pharmacological treatments have shown inconsistent findings in alleviating cognitive impairment in MS patients requiring further clarification This inconsistency regarding the effects of pharmacological interventions on cognition, coupled with the reduced ability to effectively handle everyday tasks, loss of employment and social interaction capacity, prioritizes the need for utilizing potentially more effective non-pharmacological, neurobehavioral interventions to adequately address cognitive dysfunction and everyday functioning abilities. Although the utilization of compensatory strategy training and use of external aids may be used in cognitively impaired MS patients with extensive brain atrophy, when neural plasticity mechanisms might be hampered and cortical reorganization of the brain is limited, restorative or functional cognitive training interventions utilizing either computer assisted or manualized interventions have demonstrated positive pre to post treatment effects, including good adherence, acceptability and safety rates. In this multicenter, randomized controlled trial we implemented a computer assisted (RehaCom software), functional training cognitive rehabilitation intervention of 10-weeks duration (twice weekly for 60 minutes), on (n =32) (Intervention group; IG), cognitively impaired relapsing remitting multiple sclerosis (RRMS) patients, with low disability status (EDSS = 3.14), and compared them to a demographically and clinically matched group of cognitively impaired RRMS patients (n =26) (Control group; CG), who received…
abstract: While the prevalence and pattern of cognitive dysfunction in multiple sclerosis (MS) is well documented, cognitive deterioration remains one of the most disabling characteristics of MS, and among the most difficult symptoms to manage. The impact of cognitive dysfunction in this population is significant with negative consequences on activities of daily living, loss of employment and ultimately quality of life. Past and current pharmacological treatments have shown inconsistent findings in alleviating cognitive impairment in MS patients requiring further clarification This inconsistency regarding the effects of pharmacological interventions on cognition, coupled with the reduced ability to effectively handle everyday tasks, loss of employment and social interaction capacity, prioritizes the need for utilizing potentially more effective non-pharmacological, neurobehavioral interventions to adequately address cognitive dysfunction and everyday functioning abilities. Although the utilization of compensatory strategy training and use of external aids may be used in cognitively impaired MS patients with extensive brain atrophy, when neural plasticity mechanisms might be hampered and cortical reorganization of the brain is limited, restorative or functional cognitive training interventions utilizing either computer assisted or manualized interventions have demonstrated positive pre to post treatment effects, including good adherence, acceptability and safety rates. In this multicenter, randomized controlled trial we implemented a computer assisted (RehaCom software), functional training cognitive rehabilitation intervention of 10-weeks duration (twice weekly for 60 minutes), on (n =32) (Intervention group; IG), cognitively impaired relapsing remitting multiple sclerosis (RRMS) patients, with low disability status (EDSS = 3.14), and compared them to a demographically and clinically matched group of cognitively impaired RRMS patients (n =26) (Control group; CG), who received…
author: Μεσσήνης, Λάμπρος
language: en
keywords: Cognitive rehabilitation, Single-photon emission computed tomography (SPECT), Multiple sclerosis (MS), Neuropsychological dysfunction, 616.834 075 75, Γνωστική αποκατάσταση, Τομογραφία εκπομπής μονήρους φωτονίου (SPECT), Σκλήρυνση κατά πλάκας, Νευροψυχολογικές διαταραχές
date published: 2017-08-25T06:32:42Z
date modified: 2026-07-27T20:29:45Z
provider: University of Patras
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Patras

PropertyValue
property ID: Handle
value: http://hdl.handle.net/10889/10617