Quantitative volumetric study of brain in chronic striatolenticular stroke
type: CreativeWork
description: Perforating branches of the middle cerebral artery, namely the striato-lenticular arteries provide the majority of blood supply for the striatum and posterior limb of the internal capsules. Occlusions of these arteries cause a small stroke but have a devastating effect on patients’ functions. Previous studies showed that the anterior two thirds of the internal capsule is occupied by the prefrontal tracts with the posterior one third by connection to/from sensorimotor, temporal and posterior parietal cortices. In this study, we aimed to examine the long-term effect of infarction in the striato-capsular region on cerebral cortex thickness and also its association with stroke volume and different functional tests. We hypothesized that because of extensive connections of striatum and internal capsule with the cerebral cortex, infarction of this area results in an extensive cortical thickness degeneration which could in turn cause low fictional measurement scores. High resolution T1 weighted MRI was obtained from 21 patients with ischemic stroke in the striatum/posterior limb of the internal capsule region. Subjects were carefully selected from a pool of 140 stroke cases recruited for the Northstar Stroke Project. 63 healthy volunteers (30 male), matched for age and gender were also chosen to form the control group from the OASIS database. Patients and normal subjects were right handed except for 3 patients who have the stroke in the left side of the brain. Patients were defined as left-sided stroke and right-sided stroke depending on the side of the stroke in brain. MRI scans were done 6 months to 2 years after the stroke. To measure cortical thickness, we used Freesurfer software. Vertexwise group comparison was carried out using General Linear Models (GLM). With the Significance level set at 0.05. Population maps of stroke lesions showed that the majority of strokes were located in the striatum and posterior internal capsule. Cortical thickness reduction was greater i…
abstract: Perforating branches of the middle cerebral artery, namely the striato-lenticular arteries provide the majority of blood supply for the striatum and posterior limb of the internal capsules. Occlusions of these arteries cause a small stroke but have a devastating effect on patients’ functions. Previous studies showed that the anterior two thirds of the internal capsule is occupied by the prefrontal tracts with the posterior one third by connection to/from sensorimotor, temporal and posterior parietal cortices. In this study, we aimed to examine the long-term effect of infarction in the striato-capsular region on cerebral cortex thickness and also its association with stroke volume and different functional tests. We hypothesized that because of extensive connections of striatum and internal capsule with the cerebral cortex, infarction of this area results in an extensive cortical thickness degeneration which could in turn cause low fictional measurement scores. High resolution T1 weighted MRI was obtained from 21 patients with ischemic stroke in the striatum/posterior limb of the internal capsule region. Subjects were carefully selected from a pool of 140 stroke cases recruited for the Northstar Stroke Project. 63 healthy volunteers (30 male), matched for age and gender were also chosen to form the control group from the OASIS database. Patients and normal subjects were right handed except for 3 patients who have the stroke in the left side of the brain. Patients were defined as left-sided stroke and right-sided stroke depending on the side of the stroke in brain. MRI scans were done 6 months to 2 years after the stroke. To measure cortical thickness, we used Freesurfer software. Vertexwise group comparison was carried out using General Linear Models (GLM). With the Significance level set at 0.05. Population maps of stroke lesions showed that the majority of strokes were located in the striatum and posterior internal capsule. Cortical thickness reduction was greater i…
author: Zareh, E
language: en
date published: 2010
date modified: 2026-07-24T03:44:25Z
provider: Oxford Brookes University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Oxford Brookes University