Transcriptional Adaptation of Enterococcus faecalis within Macrophages and the Role of PerA in Virulence

The intestinal ecosystem is comprised of bacteria that are both beneficial and detrimental to human health. The opportunistic pathogens residing within the gastrointestinal tract typically function as commensal members of the human microbiota. However, in certain circumstances these bacteria are able to escape the intestine and cause severe infections throughout the host. This dissertation defines the transcriptional adaptation within macrophages and elucidates the role of transcriptional regulation during pathogenicity in the opportunistic pathogen, Enterococcus faecalis.

Author dc:creator

• Maddox, Scott M.

Advisor dc:contributor.advisor

• Conway, Tyrrell

• Enterococcus faecalis
• Virulence (Microbiology)
• Macrophages
• Genetic regulation
• Transcription factors

Language dc:language

en_US

Identifier

99221341002042

OAI record oai:identifier

https://shareok.org/server/oai/request?verb=GetRecord&metadataPrefix=dim&identifier=oai%3Ashareok.org%3A11244%2F318783